Pilot study of genome-wide DNA methylation and gene expression for treatment response to escitalopram in panic disorder.

Background: Antidepressants, particularly selective serotonin reuptake inhibitors, are currently considered the first-line treatment for panic disorder (PD). However, little is known about the relationship between the biomarkers that may predict better treatment.

Aim: To compare genome-wide methylation and gene expression patterns between responsive and non-responsive patients with PD after 4 wk of escitalopram treatment.

gene polymorphisms are associated with respiratory symptoms in panic disorder.

Background: Genetic factors play an important role in the pathogenesis of panic disorder (PD). However, the effect of genetic variants on PD remains controversial.

Aim: To evaluate the associations between gene polymorphisms and PD risk and assess the effect of gene polymorphisms on the severity of clinical symptoms in PD.

Identification and characterization of noncoding RNAs-associated competing endogenous RNA networks in major depressive disorder.

Background: Major depressive disorder (MDD) is a common and serious mental illness. Many novel genes in MDD have been characterized by high-throughput methods such as microarrays or sequencing. Recently, noncoding RNAs (ncRNAs) were suggested to be involved in the complicated environmental-genetic regulatory network of MDD occurrence; however, the interplay among RNA species, including protein-coding RNAs and ncRNAs, in MDD remains unclear.

Experimental study on pollutant movement in surf zone.

The experiments on pollutant movement in surf zone were conducted on the two gentle beaches (with slope of 1:100 and 1:40, respectively), for diverse wave cases. The movement contours and direction of pollutants, under the action of regular and random waves with diverse wave amplitudes, were provided and studied in this paper. It was shown that, due to complicated hydrodynamics in surf zone, the pollutant movement state is quite complicated and different from that in pure current zone.