Artificial Intelligence-Assisted Prescription Determination for Orthokeratology Lens Fitting: From Algorithm to Clinical Practice.

Objectives: To explore the potential of artificial intelligence (AI) to assist prescription determination for orthokeratology (OK) lenses.

Methods: Artificial intelligence algorithm development followed by a real-world trial. A total of 11,502 OK lenses fitting records collected from seven clinical environments covering major brands.

Efficacy of contact lenses for myopia control: Insights from a randomised, contralateral study design.

Purpose: To determine the efficacy of two myopia control contact lenses (CL) compared with a single-vision (SV) CL.

Methods: Ninety-five Chinese children with myopia, aged 7-13 years in a 1-year prospective, randomised, contralateral, cross-over clinical trial with 3 groups; bilateral SVCL (Group I); randomised, contralateral wear of an extended depth of focus (EDOF) CL and SVCL (Group II) and MiSight® CL and SVCL (Group III). In Groups II and III, CL were crossed over at the 6-month point (Stage 1) and worn for a further 6 months (Stage 2).

Genipin inhibits the scleral expression of miR-29 and MMP2 and promotes COL1A1 expression in myopic eyes of guinea pigs.

Purpose: High myopia can lead to blindness. Genipin is a collagen cross-linking agent that may be used to treat myopia. However, the mechanism of action of genipin for the treatment of myopia is unclear.

Effects of the long wavelength-filtered continuous spectrum on natural refractive development in juvenile guinea pigs.

Aim: To investigate the effects of spectral composition and light intensity on natural refractive development in guinea pigs.

Methods: A total of 124 pigmented guinea pigs (2-week-old) were randomly assigned to three groups at high (Hi; 4000 lx), medium (Me; 400 lx) and low (Lo; 50 lx) light intensities under a 12:12 light/dark cycle for 6wk. Each group was subdivided into subgroups with the following spectra: broad spectrum Solux halogen light (BS), 600 nm above-filtered continuous spectrum (600F), 530 nm above-filtered continuous spectrum (530F), and 480 nm above-filtered continuous spectrum (480F; HiBS: =10, Hi600F: =10, Hi530F: =10, Hi480F: =10, MeBS: =10, Me600F: =10, Me530F: =10, Me480F: =10, LoBS: =11, Lo600F: =12, Lo530F: =10, Lo480F: =11).

A novel apparatus for interocular interaction evaluation in children with and without anisometropic amblyopia.

Background: Dichoptic visual stimulation may be achieved using shutter goggles and mirror systems. These methods vary in their feasibility for use in children. This study aims to investigate the feasibility of use of a simple trial frame-based system to evaluate interactions in children.

[The strategy of determining the customized near addition lens for juvenile esophoric myopes].

Objective: To discuss accommodative lag and near phoria varying with the near addition lenses and establish the mathematic equations of near adds and accommodative lag, near phoria respectively in order to getting the optimal adds, which would create the least error in accommodative and convergence responses.

Methods: To measure accommodative lag by Shin-Nippon and near phoria by Cover Test in 33 cm after providing 0D, +0.75D, +1.