Publications by authors named "Zhi-Kai Hu"
Article Synopsis
- This study investigates the potential of long non-coding RNAs (lncRNAs) in peripheral blood as non-invasive biomarkers for acute rejection (AR) in kidney transplants.
- Researchers analyzed lncRNA expression profiles in 150 blood samples from both pediatric and adult transplant recipients to identify differences between those experiencing AR and those who are not.
- They identified 23 lncRNAs common to both groups that could effectively distinguish AR cases, and created a risk score using two significant lncRNAs that showed strong diagnostic performance, making them promising candidates for AR detection in kidney transplant patients.
Article Synopsis
- Clear cell renal cell carcinoma (ccRCC) is the most common type of kidney cancer in adults, and this study focused on analyzing microRNA (miRNA) expression profiles to distinguish between tumors with mutant and wild-type mutation statuses.
- The researchers identified 33 differentially expressed miRNAs, 11 of which were significantly associated with overall survival in patients with wild-type status, contributing to a newly developed mutation-specific miRNA signature.
- This miRNA signature, involving 11 key miRNAs, has the potential to act as a new prognostic biomarker for ccRCC patients, potentially aiding in patient management and treatment strategies.
Article Synopsis
- Ischemic preconditioning (IPC) helps protect the kidneys from damage caused by ischemia-reperfusion injury (IRI), although the exact mechanisms are still not fully understood.* -
- In a study with male Sprague-Dawley rats, different treatment groups were established to assess how IPC affects renal function, blood flow, and key nitric oxide synthase levels following vascular clamping.* -
- Results showed that IPC significantly improved kidney function and blood flow, linked to increased levels of endothelial and inducible nitric oxide synthase (eNOS/iNOS) and nitric oxide (NO), though these benefits were negated when nitric oxide production was inhibited.*
Papillary renal cell carcinoma (pRCC) is the second most prevalent subtype of kidney cancers. In the current study, we analyzed the global microRNA (miRNA) expression profiles in pRCC, with the aim to evaluate the relationship of miRNA expression with the progression and prognosis of pRCC.A total of 163 treatment-naïve primary pRCC patients were identified from the Cancer Genome Atlas dataset and included in this retrospective observational study.
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- The study investigates the effect of high-dose erythropoietin (EPO) on kidney graft function after transplantation, aiming to clarify its efficacy due to inconclusive findings from previous trials.
- A meta-analysis of 4 randomized controlled trials involving 356 patients showed a trend towards reduced delayed graft function in the EPO group, but it wasn't statistically significant.
- The results suggest that while high-dose EPO might help protect kidney function, it does not significantly raise the risk of adverse events compared to placebo.
Article Synopsis
- * Researchers analyzed miRNA expression profiles from tumor tissues and adjacent normal tissues in ccRCC patients, applying various statistical analyses to establish correlations with survival rates.
- * A total of 147 differentially expressed miRNAs were identified, leading to the creation of a tumor-specific signature of 22 miRNAs, which was validated as an independent prognostic factor for ccRCC.