The Effects of Charged Amino Acid Side-Chain Length on Diagonal Cross-Strand Interactions between Carboxylate- and Ammonium-Containing Residues in a β-Hairpin.

The β-sheet is one of the common protein secondary structures, and the aberrant aggregation of β-sheets is implicated in various neurodegenerative diseases. Cross-strand interactions are an important determinant of β-sheet stability. Accordingly, both diagonal and lateral cross-strand interactions have been studied.

Crystal structure of dihydropyrimidinase in complex with anticancer drug 5-fluorouracil.

Dihydropyrimidinase (DHPase) catalyzes the reversible cyclization of dihydrouracil to N-carbamoyl-β-alanine in the second step of the pyrimidine degradation pathway. Whether 5-fluorouracil (5-FU), the best-known fluoropyrimidine that is used to target the enzyme thymidylate synthase for anticancer therapy, can bind to DHPase remains unknown. In this study, we found that 5-FU can form a stable complex with Pseudomonas aeruginosa DHPase (PaDHPase).

Plasmon resonance scattering at perovskite CH3NH3PbI3 coated single gold nanoparticles: evidence for electron transfer.

We demonstrate the electron transfer between gold nanoparticles and perovskite CH3NH3PbI3 at a single nanoparticle level by plasmon resonance Rayleigh scattering spectroscopy. Different mass concentrations of CH3NH3PbI3 show different formations of crystal grains on the gold nanoparticles, which led to different degrees of red-shift.

[Emotional problems and parenting locus of control in children with anxiety disorders].

Objective: To carry out a preliminary study on the emotional problems and parenting locus of control among children with anxiety disorders.

Methods: A total of 110 children with simple anxiety disorders (AD group) and 113 normal children (control group) from September to December 2005 were enrolled. Children were asked to complete the Depression Self-Rating Scale for Children (DSRSC), the Screen for Child Anxiety Related Emotional Disorders (SCARED), and the Parenting Locus of Control Scale (PLOC).

[Prevalence of psychiatric disorders in primary and middle school students in Hunan Province].

Objective: To investigate the prevalence of psychiatric disorders in a representative sample of primary and middle school students in Hunan Province.

Methods: A total of 9 495 children aged 5-17 years from Hunan urban and rural schools were enrolled by a cluster sampling and a two-phase design. The students' psychiatric status was assessed using the Investigation Screening Inventory for Child Mental Disorder and a semi-structured interview designed based on the DSM-IV criteria.

[A case-control study on family environment related factors in attention deficit hyperactivity disorder with anxiety disorder].

Objective: To study the family rearing pattern of attention deficit hyperactivity disorder (ADHD) with or without anxiety disorder and to explore its risk factors.

Methods: 9495 children and their parents were sampled at random in Hunan province, using two-stage investigation. Those who were diagnosed ADHD and the normal control filled out Egna Minnen av Barndoms Uppfostran and family adaptability and cohesion scale by themselves.