Publications by authors named "Zhi-Jun Fang"

Objective: This study analyzed the long-term arteriovenous fistula (AVF) patency rate and its determinants in patients undergoing maintenance hemodialysis.

Methods: General data and laboratory examinations of hemodialysis patients were collected retrospectively. The primary patency time, primary functional patency time, cumulative patency time, cumulative functional patency time, and temporary central venous catheterization (CVC) time were counted.

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Chemotherapy is applied to treat non-small cell lung cancer (NSCLC), but often limited due to its unstable therapeutic effects and adverse reactions (ADRs). Ginseng and its main ingredients (ginsenosides and polysaccharides) have been clinically used as adjuvants to chemotherapy. However, their efficacies were based on individual trials with relatively small sample sizes, and it is difficult to draw a valid conclusion.

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Background: Recurrent intracranial aneurysms (RAs) remain a daunting challenge for neurosurgeons. This study aimed to explore a potential optimal management strategy of RAs by reviewing the characteristics and management outcomes of 117 RAs.

Methods: A total of 117 patients with RAs were treated in a single neurosurgical center from January 2011 to January 2017.

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Article Synopsis
  • Cyclophosphamide (CP) is a chemotherapy drug that can cause liver damage, leading to restricted use due to its hepatotoxic side effects.
  • Ginseng has been used alongside CP in China, and this study investigates how it can protect the liver from CP-induced damage, revealing that ginseng helps normalize liver enzyme levels and enhances antioxidant activity.
  • The research shows that ginseng influences the metabolism of glutathione (GSH) and bile acids, possibly through the up-regulation of NRF2, improving the liver's ability to cope with the toxic effects of CP.
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Identification of specific etiological carcinogens is one of the most important issues in environmental-toxicology studies. In this study, cDNA microarrays were used to analyze gene expression and discern chemical-associated profiles induced by a variety of tumor promoting agents in transformed cells. Two-stage transformation model of BALB/c 3T3 cells was established with MNNG as initiator, and 12-O-tetradecanoylphorbol-13-acetate (TPA), okadaic acid (OA), or cadmium chloride (CdCl(2)) as tumor promoters.

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The text analyzes the reasons of medical devices adverse events occurrence from manufacturers, medical institutions and patients. To guard against the events, the medical institutions should put emphasis on check of purchasing, informed consent, technical permission, SOP performing, the safe of medical and enhance monitoring etc.

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