Publications by authors named "Zhi-Hua Wan"
Article Synopsis
- The study aimed to evaluate the effectiveness of combining the modified Caprini score with D-dimer levels to assess and manage lower extremity venous thrombosis in lung cancer surgery patients.
- A total of 224 patients were analyzed, with their risk categorized based on the modified Caprini score, and ultrasonography was used to identify any venous thrombosis.
- Results showed significant differences in venous thrombosis rates among the risk groups, with a notable 37.1% in the high-risk group, alongside significant differences in D-dimer levels between patients with and without thrombosis post-surgery.
Article Synopsis
- The study reports on a patient with concurrent primary prostate adenocarcinoma and renal cell carcinoma, emphasizing the importance of diagnosis and treatment outcomes.
- A 62-year-old man was found to have renal cell carcinoma through a CT scan and prostate cancer from abnormal PSA levels, leading to a series of diagnostic tests.
- The report highlights that continuous monitoring of patients with renal cell carcinoma for prostate adenocarcinoma could enhance early detection and treatment, as this case is unique in its detailed documentation of the diagnostic process.
Article Synopsis
- * In a rat model of T2DM induced by a high-fat diet and streptozotocin injections, increased GRK2 levels were found to impair blood vessel function, reduce nitric oxide production, and lead to worse erectile function.
- * Treatment with a GRK2 inhibitor, paroxetine, improved the signaling pathways related to endothelial function, reduced oxidative stress, and helped maintain erectile function, suggesting that targeting GRK2 could be a potential therapeutic strategy for
Article Synopsis
- Cavernous nerve injury (CNI) leads to erectile dysfunction by causing fibrosis and loss of smooth muscle cells (SMCs) in the penis, with lysyl oxidase (LOX) being a key player in this process.
- The study aimed to assess the impact of LOX on penile fibrosis following bilateral CNI in rats, utilizing a LOX inhibitor (β-aminopropionitrile) for treatment.
- Results showed that after CNI, LOX activity increased while SMC content decreased, contributing to erectile dysfunction; however, LOX inhibition helped improve erectile function and preserve SMCs, suggesting a potential therapeutic approach to tackle penile fibrosis.
Article Synopsis
- * It found that higher levels of specific phthalate metabolites (MEHHP, MEOHP, MEHP) were associated with increased ADHD symptoms and oppositional defiant disorder (ODD) in a dose-dependent manner.
- * Additionally, associations were discovered between phthalate concentrations and various behavioral issues, including inattention, aggression, and internalizing behaviors, suggesting phthalate exposure may negatively impact child behavior.
Efficacy of metformin on pregnancy complications in women with polycystic ovary syndrome: a meta-analysis.
Gynecol Endocrinol
September 2016
Article Synopsis
- The objective of the study was to assess how effective metformin is in reducing pregnancy complications in women with polycystic ovary syndrome (PCOS) when taken throughout their pregnancy.
- The analysis included five studies with a total of 502 PCOS patients who used metformin during pregnancy, compared to 427 controls who used it only for conception.
- Results indicated that continuous metformin use significantly lowered the risk of miscarriage and premature birth, but did not show a meaningful impact on gestational diabetes or pre-eclampsia.
Article Synopsis
- The study investigates the role of calpain, an enzyme linked to neurodegenerative diseases, in erectile dysfunction (ED) caused by cavernous nerve injury in rats.
- Rats subjected to cavernous nerve crush were treated with a calpain inhibitor, MDL-28170, which showed improved erectile function and expression of key proteins related to nerve health.
- The findings suggest that inhibiting calpain may be a promising strategy for preventing ED following cavernous nerve damage.
Article Synopsis
- The study aimed to investigate how recombinant adenovirus carrying PDE5-targeting shRNAs affects calcium levels in rat penile smooth muscle cells, with potential applications in treating erectile dysfunction (ED).
- Researchers transfected rat smooth muscle cells with specific shRNAs and measured calcium activity using a fluorescent probe over 24, 48, and 72 hours, observing the changes through a laser scanning confocal microscope.
- Results showed that the intracellular calcium levels in the shRNA group were significantly lower compared to control groups, indicating that adenovirus-mediated shRNAs can effectively reduce calcium levels in penile smooth muscle cells, suggesting a promising gene therapy approach for ED.
[Impact of rAd5-shRNA- PDE5A3 on cGMP in the smooth muscle cells of human corpus cavernosum].
Zhonghua Nan Ke Xue
August 2009
Article Synopsis
- The study aimed to explore how phosphodiesterase type 5 (PDE5) small interfering RNA (siRNA) affects cGMP levels in human corpus cavernosum smooth muscle cells, potentially aiding in erectile dysfunction treatment.
- Researchers constructed a specific adenovirus (rAd5-shRNA-PDE5A3) and applied it to different groups of smooth muscle cells to measure cGMP concentrations over time.
- Results showed that the group treated with rAd5-shRNA-PDE5A3 had significantly elevated cGMP levels compared to control groups, particularly at 72 hours, suggesting its effectiveness in inhibiting the PDE5 gene.