Direct Assembly of Polysubstituted Naphthalenes via a Tandem Reaction of Benzynes and α-Cyano-β-methylenones.

A mild and transition-metal-free benzannulation reaction for the construction of the naphthalene skeleton has been described. Benzynes react with α-cyano-β-alkylenones through a tandem nucleophilic addition/cyclization/aromatization process to afford polysubstituted naphthalenes in 50-94% yields.

NHCs catalyzed hydrophosphonylation of α-ketoesters and α-trifluoromethyl ketones.

N-Heterocyclic carbenes catalyzed hydrophosphonylation reaction of α-ketoesters and α-trifluoromethyl ketones was developed. Under the catalysis of 10 mol% IPr, α-ketoesters or α-trifluoromethyl ketones reacted with dialkyl phosphites to provide quaternary α-hydroxyphosphonates in good to excellent yield.

[A novel SMOreg algorithm based on instance cloned and its research on spectral modeling for hydromica in uranium deposit].

Hydromica is a typical alteration mineral in granite-type uranium deposit, and also an important indication of uranium. The amount of hydromica to some extent reflects the strength of hydromicasization in uranium deposit. Because of the bad performance of the traditional modelling methods in prediction, in the present paper, the authors' adopt SMOreg in the spectral modelling for hydromica, and validate its effectiveness.

[Combination of improved sex therapy and sildenafil for erectile dysfunction in Uigur men: retrospective analysis of 2505 cases].

Objective: The sex therapy is not yet popularized at present. This study aimed to evaluate the effect of the combination of the improved sex therapy and oral sildenafil on erectile dysfunction (ED).

Methods: A total of 3130 Uigur cases of ED received in Xinjiang Bogda Hospital were divided into a control group (n=625) and a trial group (n=2505), the former treated with oral sildenafil alone, and the latter by the combination of the improved genital therapy and sildenafil, both for 3 months and followed up at 6 and 12 months after the treatment.