Transcutaneous electrical acupoint stimulation for hypertension complicated by anxiety or sleep disorders: A pilot randomized controlled trial.

Background: Hypertension is often accompanied by anxiety and sleep disorders, which further complicate the disease. This study aimed to evaluate the feasibility and effectiveness of transcutaneous electrical acupoint stimulation (TEAS) in patients with hypertension and anxiety or sleep disorders.

Methods: Eligible participants were randomly assigned to the 10 Hz TEAS, 2 Hz TEAS, or routine treatment groups in a 1:1:1 ratio.

Severe congenital neutropenia and liver abscess: Surgical treatment breaks the vicious cycle.

Here, we present a case with genetically confirmed SCN. The main symptom of the child was recurring fever. The combination of antibiotics combined with G-CSF injection was proved to be insufficient, and the patient developed "solid" liver abscess.

Dopamine Functionalized Polyethylene Glycol for Improving Stability of Gold Nanoparticles against Reactive Oxygen Species in Serum.

PEGylation is the most effective antifouling method for the surface modification of gold nanoparticles (AuNPs). However, thiol-terminated polyethylene glycol (PEG) ligands tethered on the AuNPs are instable in serum and can detach from the AuNP surface, resulting in a significant reduce of their antifouling properties. Herein, it is reported that reactive oxygen species (ROS) is a major factor causing the detachment of PEG ligands from AuNP surfaces.

PHLDA3 promotes lung adenocarcinoma cell proliferation and invasion via activation of the Wnt signaling pathway.

The PHLDA3 gene encodes a small 127 amino acid protein with a pleckstrin homology (PH)-only domain. The expression and significance of PHLDA3 in lung cancer remain unclear. Here, we investigated the role of PHLDA3 in tumor proliferation and invasion in lung adenocarcinoma.

DEK is highly expressed in breast cancer and is associated with malignant phenotype and progression.

DEK proto-oncogene (DEK) has been demonstrated as an oncogene and is associated with the development of many types of tumor; however, the expression and role of DEK in breast cancer remain unknown. The present study aimed to determine the role of DEK in the progression of breast cancer. The expression of DEK in 110 breast cancer tissues and 50 adjacent normal breast tissues was examined using immunohistochemistry.

TRIP13 promotes the proliferation and invasion of lung cancer cells via the Wnt signaling pathway and epithelial-mesenchymal transition.

Thyroid hormone receptor interactor 13 (TRIP13) is an ATPase that has been found to be overexpressed in many tumors. The aim of this study was to investigate the role of TRIP13 and its mechanism of action in lung cancer. The expression of TRIP13 was examined in lung cancer tissues and corresponding normal lung tissues by western blotting.

FAM83A Promotes Lung Cancer Progression by Regulating the Wnt and Hippo Signaling Pathways and Indicates Poor Prognosis.

FAM83A (family with sequence similarity 83, member A) has been found to be highly expressed in cancers. The purpose of this study was to clarify the role and mechanism of FAM83A in lung cancers. The expression of FAM83A in lung cancer cells was enhanced by gene transfection or knocked down by small interfering RNA interference.

DEK promotes the proliferation and invasion of lung cancers and indicates poor prognosis in lung adenocarcinomas.

DEK has been revealed to be overexpressed in many cancers and associated with cancer progression. The aim of the present study was to elucidate the role of DEK with a specific focus on its underlying mechanism in lung cancers. DEK expression in lung cancers and normal lung tissues and the correlations between DEK expression and clinicopathological parameters of lung cancers were investigated using the data from The Cancer Genome Atlas (TCGA).

Overexpression of KRT17 promotes proliferation and invasion of non-small cell lung cancer and indicates poor prognosis.

Purpose: Keratin 17 (KRT17) is a 48 KDa type I intermediate filament, which is mainly expressed in epithelial basal cells. KRT17 has been shown to be overexpressed in many malignant tumors and play an important role in the occurrence and development of tumors. Therefore, this study explored the role and underlying mechanism of KRT17 in non-small cell lung cancers (NSCLC).

Association of C8orf4 expression with its methylation status, aberrant β-catenin expression, and the development of cervical squamous cell carcinoma.

Chromosome 8 open reading frame 4 (C8orf4) is an activator of Wnt signaling pathway, and participates in the tumorigenesis and progression of many tumors. The expression levels of C8orf4 and β-catenin were assessed via immunohistochemical staining in 100 cervical squamous cell carcinoma (CSCC) tissues, 50 high-grade squamous intraepithelial lesions (HSILs), 50 low-grade squamous intraepithelial lesions (LSILs), and 50 normal cervical tissues. Bisulfite sequencing polymerase chain reaction analysis was used to examine the methylation status of the C8orf4 locus in CSCC and normal cervical tissues.

Primary malignant mesothelioma of the diaphragm with liver invasion: A case report and review of literature.

Rationale: Malignant mesothelioma is a malignant tumor with poor prognosis, which usually originates in the pleura, peritoneum, and pericardial cavity. Mesotheliomas that originate from the diaphragm are very rare. Here, we report a case of primary malignant mesothelioma of the diaphragm with liver invasion.

Mussel-inspired nano-silver loaded layered double hydroxides embedded into a biodegradable polymer matrix for enhanced mechanical and gas barrier properties.

In this paper, a facile, green and mussel-inspired method is presented to prepare silver loaded layered double hydroxides (Ag-LDHs@PDA and Ag-LDHs@TA-Fe(iii)) using a pre-synthesis polydopamine (PDA)/tannic acid (TA)-Fe(iii) layer as a nanoscale guide and PDA/TA itself as a reducing reagent to form uniform silver nanoparticles (AgNPs) on the surface of modified LDHs. Meanwhile, another kind of LDH, Ag-LDHs(PVP), was prepared the direct reduction of the precursor [Ag(NH)] with polyvinyl pyrrolidone (PVP). And three kinds of Ag-LDHs/poly(ε-caprolactone) (PCL) nanocomposite were prepared by blending Ag-LDHs and pure PCL a solution casting method to obtain homogeneous films.

PRDM16 functions as a suppressor of lung adenocarcinoma metastasis.

Background: The transcription factor PR domain containing 16 (PRDM16) is known to play a significant role in the determination and function of brown and beige fat. However, the role of PRDM16 in tumor biology has not been well addressed. Here we investigated the impact of PRDM16 on tumor growth and metastasis in lung cancer.

Overexpression of Nemo-like Kinase Promotes the Proliferation and Invasion of Lung Cancer Cells and Indicates Poor Prognosis.

Background: Nemo-like kinase (NLK) is an evolutionarily conserved MAP kinaserelated kinase involved in the pathogenesis of several human cancers.

Objective: The aim of this study was to investigate the expression and role of NLK in lung cancers, and its underlying mechanisms.

Methods: We examined the expression of NLK in lung cancer tissues through western blot analysis.

An evidence-based etiology study of synovial cyst of knee cruciate ligament: a real or pseudo-cyst.

Purpose: Synovial cyst of knee cruciate ligament (SCKCL) is a rare condition but can cause severe knee pain. The understanding of its etiology is relatively poor. This current study aimed to elucidate the pathogenesis of SCKCL based on a series of histo- and cytopathological examination.

Odd-skipped related 1 inhibits lung cancer proliferation and invasion by reducing Wnt signaling through the suppression of SOX9 and β-catenin.

The odd-skipped related 1 (OSR1) gene encodes a zinc-finger transcription factor. The expression and significance of OSR1 in human tumors remains unclear. We found that OSR1 was downregulated in lung cancers, and its expression was correlated with poor differentiation.

B7-H4 is Predictive of Poor Prognosis in Patients with Gastric Cancer.

BACKGROUND Recently, some studies were performed to evaluate the relevance of B7-H4 and gastric cancer (GC) prognosis. However, the results remained controversial. Therefore, we performed the present meta-analysis.

The geometry of the bone structure associated with total hip arthroplasty.

Close adaptation of the prosthesis to the bone is the key to achieving optimal stability and fixation for total hip arthroplasty (THA). However, there have been no adequate studies of bone morphology, especially in different races. The aim of this study was to analyze the geometry of the acetabulum and proximal femur of people from South China, based on three-dimensional reconstruction, and to detect differences between different population subsets.

Measurement and comparison of tibial posterior slope angle in different methods based on three-dimensional reconstruction.

Background: The tibial posterior slope (PTS) is an important parameter for sagittal alignment which is associated with postoperative range of motion. However, the variations of different population subsets and different referential axes are still uncertain.

Methods: In this study, 80 healthy people from South China were recruited and measured on three-dimensional reconstruction of CT, with application of three referential axes, the proximal tibial long axis, the anterior and posterior cortices.

The efficacy and safety of infliximab used in patients with ankylosing spondylitis after unilateral total hip arthroplasty.

A retrospective study was performed in patients with ankylosing spondylitis (AS) from south China, to investigate the efficacy and safety of infliximab after total hip arthroplasty (THA). Thirty-two AS patients were divided into two groups. The treatmen group recieved infliximab at four weeks after unilateral THA (11 patients) and were compare to a control group (21 patients).

Porous tantalum rod implant is an effective and safe choice for early-stage femoral head necrosis: a meta-analysis of clinical trials.

Background And Purpose: Femoral head necrosis (FHN) is a debilitating disease which seriously affects the patients' quality of life, especially the young. The porous tantalum rod has the advantages of high volumetric porosity, low modulus of elasticity, and excellent osteoinduction, with exceptional biocompatibility and safety record in clinical application, which makes it an ideal choice for FHN patients. However, there has not been a systematic analysis for its efficacy and safety.

Etanercept in the treatment of ankylosing spondylitis: a meta-analysis of randomized, double-blind, placebo-controlled clinical trials, and the comparison of the Caucasian and Chinese population.

Background And Purpose: Ankylosing spondylitis (AS) is a kind of rheumatic disease, leading to pain, fatigue, stiffness, and functional impairment, which seriously affects the quality of life. Etanercept, a fully human recombinant protein, has been applied for the treatment of AS. However, there has not been a systematic analysis for its efficacy and safety.

Do patients benefit from tourniquet in arthroscopic surgeries of the knee?

Purpose: To undertake a meta-analysis of randomized controlled trials to determine whether routine use of a tourniquet is a better choice for knee arthroscopic procedures.

Methods: Randomized controlled trials which evaluated the application of a tourniquet were selected, gathering information about arthroscopic visualization and operative time. The random-effects meta-analysis was performed using relative risk calculated from the raw data.