Study of pharmacokinetics and tissue distribution of liposomal brucine for dermal administration.

Objective: To evaluate the pharmacokinetics and tissue distribution of liposomal brucine (LB) for dermal application.

Methods: Pharmacokinetics and tissue distribution were studied by in vivo animal testing. High performance liquid chromatography (HPLC) was used to detect the concentration of brucine in rats' skin, plasma and various tissues.