Publications by authors named "Zhi-Cong Qiu"
Article Synopsis
- Hypertrophic cardiomyopathy (HCM) is a genetic heart condition causing abnormal thickening of the heart muscle, leading to possible heart failure or death, and is linked to the process of autophagy (AT), which helps cells recycle damaged components.
- The study explored the impact of autophagy-related genes (ARGs) in HCM using bioinformatics and experimental methods, identifying key genes linked to myocardial hypertrophy.
- Five genes were pinpointed as potential biomarkers for HCM diagnosis and treatment, and ten therapeutic compounds were suggested, indicating that changes in ARG levels could help in developing diagnostics and therapies for HCM.
Ischemic cardiomyopathy (ICM) is a serious cardiac disease with a very high mortality rate worldwide, which causes myocardial ischemia and hypoxia as the main damage. Further understanding of the underlying pathological processes of cardiomyocyte injury is key to the development of cardioprotective strategies. Ferroptosis is an iron-dependent form of regulated cell death characterized by the accumulation of lipid hydroperoxides to lethal levels, resulting in oxidative damage to the cell membrane.
View Article and Find Full Text PDFAccumulating evidence shows that the abnormal proliferation and migration of vascular smooth muscle cells (VSMCs) can significantly affect the long-term prognosis of coronary artery bypass grafting. This study aimed to explore the factors affecting the proliferation, migration, and phenotypic transformation of VSMCs. First, we stimulated VSMCs with different platelet-derived growth factor-BB (PDGF-BB) concentrations, analyzed the expression of phenotype-associated proteins by Western blotting, and examined cell proliferation by scratch wound healing and the 5-ethynyl-2-deoxyuridine (EdU) assay.
View Article and Find Full Text PDF