Publications by authors named "Zhi-Cong He"
Dinotefuran is a chiral neonicotinoid that is widely distributed in environmental matrices, but its health risks to different organisms are poorly understood. This study investigated the neurotoxic responses of honeybee/cotton aphid nicotinic acetylcholine receptors (nAChRs) to chiral dinotefuran at the enantiomeric scale and demonstrated the microscopic mechanism of species selectivity in nAChR-mediated enantioselective neurotoxicity. The findings indicated that (S)-dinotefuran had a higher affinity for honeybee nAChR than (R)-dinotefuran whereas both enantiomers exhibited similar bioactivity toward cotton aphid nAChR.
View Article and Find Full Text PDFThe nitrogen removal efficiency and distribution of microbial community in a denitrification process aided by zero-valent iron (ZVI) under low carbon-to-nitrogen ratio (C/N) were assessed in this study. Experimental results demonstrated that the nitrogen removal efficiency (TNRE) increased to 96.4 ± 2.
View Article and Find Full Text PDFArticle Synopsis
- Chiral organophosphorus pollutants, specifically isocarbophos, pose neurotoxic risks that haven't been fully evaluated, prompting research into their effects on nerve cells (SH-SY5Y) and the role of acetylcholinesterase (AChE).
- Cell assays reveal that one enantiomer of isocarbophos is significantly more toxic than the other, with distinct inhibitory effects on cell survival and AChE activity, showing a clear dependence on dosage.
- Molecular experiments highlight that the differing toxic actions are due to variations in how the two enantiomers interact with AChE, particularly through noncovalent interactions influenced by the structural characteristics of isocarboph