Publications by authors named "Zhi-Cheng Yuan"
Cadmium is one of the most common heavy metal contaminants found in agricultural fields. MutSα, MutSβ, and MutSγ are three different MutS-associated protein heterodimer complexes consisting of MSH2/MSH6, MSH2/MSH3, and MSH2/MSH7, respectively. These complexes have different mismatch recognition properties and abilities to support MMR.
View Article and Find Full Text PDFArticle Synopsis
- - The study examines how mitochondrial damage-related molecules affect lung fluid balance during acute lung injury, utilizing both human patients and gene-altered mice as subjects.
- - Researchers found that exposure to these mitochondrial molecules worsened lung fluid imbalance, while the absence of the formyl peptide receptor-1 gene in mice showed a reduction in this imbalance.
- - Proteomic analysis showed that specific proteins related to ion channels and cell barriers were affected by mitochondrial patterns, leading to decreased stability in rat lung cells via the formyl peptide receptor-1 pathway.
Long non-coding RNAs (lncRNAs) are involved in various biological processes as well as many respiratory diseases, while the role of lncRNAs in acute lung injury (ALI) remains unclear. The present study aimed to profile the expression of lung lncRNAs and mRNAs in lipopolysaccharide (LPS)-induced ALI mouse model. C57BL/6 mice were exposed to LPS or phosphate-buffered saline for 24 h, and lncRNAs and mRNAs were profiled by Arraystar mouse LncRNA Array V3.
View Article and Find Full Text PDFMitochondrial peptides cause proinflammatory responses in the alveolar epithelium via FPR-1, MAPKs, and AKT: a potential mechanism involved in acute lung injury.
Am J Physiol Lung Cell Mol Physiol
November 2018
Article Synopsis
- Acute lung injury (ALI) leads to lung inflammation and damage to the alveolar epithelium, with mitochondrial damage-associated molecular patterns (DAMPs) like N-formyl peptides (NFPs) playing a significant role in this process.
- In murine models, elevated mitochondrial NADH dehydrogenase 1 and increased formyl peptide receptor (FPR)-1 expression were linked to worse lung injury, while the use of Cyclosporin H (CsH), an FPR1 inhibitor, reduced inflammation.
- The study highlights the involvement of alveolar epithelial cells in the immune response to MTDs during ALI, suggesting a signaling mechanism that includes increased IL-8 production through FPR-1
Objective In cerebral aneurysm clipping and embolization, blood pressure control and temporary parent artery blocking are common methods to prevent aneurysm rupture. Their influence on the prognosis is uncertain. In this study, we try to find out the association between methods above and prognostic indicators.
View Article and Find Full Text PDFIntravascular infusion of lidocaine: a novel way to relieve sudden internal carotid artery occlusion in embolization of intracranial aneurysms.
J Neurol Surg A Cent Eur Neurosurg
March 2012
Article Synopsis
- The study looks at a dangerous problem called vasospasm that can happen during a specific brain procedure known as embolization of aneurysms.
- Doctors compared two treatments: one using a medicine called papaverine and another using lidocaine to see which one worked better.
- Results showed that patients treated with lidocaine had a much better chance of improvement compared to those who received papaverine, making lidocaine a more effective option.
[Mechanism of ING4 mediated inhibition of the proliferation and migration of human glioma cell line U251].
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi
November 2011
Aim: To investigate the effect of Ad-ING4 on proliferation and migration of glioma cells and explore its probable mechanism.
Methods: U251 were infected with Ad-ING4. ING4 gene expression was evaluated by RT-PCR.
Background: Recent studies have discovered that nuclear translocation of nerve growth factor (NGF) and its receptor fragments function differently from the traditional model. This study aimed to uncover the nuclear expression of NGF in astrocytoma and its biological significance.
Methods: Ninety-four paraffin-embedded astrocytoma specimens were subjected to immunohistochemical (IHC) and hemotoxylin & eosin (HE) staining.