Expression of Glut-1 and HK-II in Pancreatic Cancer and Their Impact on Prognosis and FDG Accumulation.

Objective: The purpose of this article is to analyze the expression of Glut-1 and HK-II, the association between their expression and F-FDG accumulation in pancreatic cancer.

Methods: Fifty patients with histologically proven pancreatic cancer were included in this preliminary study, all of whom received F-FDG PET/CT performance before surgery. Immunohistochemical staining of tumor tissue and adjacent normal tissue was performed for Glut-1 and HK-II.

Mucosa-reparing and microbiota-balancing therapeutic effect of alleviates dextrate sulfate sodium-induced ulcerative colitis in mice.

Gut microbiota composition of patients with ulcerative colitis (UC) is markedly altered compared with healthy individuals. There is mounting evidence that probiotic therapy alleviates disease severity in animal models and patients with inflammatory bowel disease (IBD). , as a probiotic, has also demonstrated a protective effect in IBD.

Surgery for left ventricular aneurysm after myocardial infarction: techniques selection and results assessment.

Background: The most appropriate surgical approach for patients with post-infarction left ventricular (LV) aneurysm remains undetermined. We compared the efficacy of the linear versus patch repair techniques, and investigated the mid-term changes of LV geometry and cardiac function, for repair of LV aneurysms.

Methods: We reviewed the records of 194 patients who had surgery for a post-infarction LV aneurysm between 1998 and 2010.

Effect of recombinant Lactobacillus casei expressing interleukin-10 in dextran sulfate sodium-induced colitis mice.

Objective: To study the effect of recombinant Lactobacillus casei (L.casei) expressing interleukin (IL)-10 combined with 5-aminosalicylic acid (5-ASA) in dextran sulfate sodium (DSS)-induced colitis mice.

Methods: Recombinant L.

Osteopontin is required for angiotensin II-induced migration of vascular smooth muscle cells.

Migration and proliferation of vascular smooth muscle cells (VSMCs) play a prominent role in the development of atherosclerotic plaques and restenosis lesions. Angiotensin II (Ang-II) is typically associated with excessive proliferation and migration of VSMCs and vascular remodeling. High levels of osteopontin (OPN) mRNA and protein were reported in human atherosclerotic plaque from the aorta, carotid and coronary arteries.

Role of osteopontin in the development of neointimal hyperplasia in vein grafts.

Objectives: Neointimal hyperplasia and superimposed atherosclerosis are central to late vein graft failure following coronary artery bypass grafting. Recent studies on post-injury arterial vessels have suggested a role of osteopontin (OPN) in the process of vascular remodelling. This study was designed to assess the in vivo performance of OPN following vein grafting.

[Surgical treatment of post-infarction left ventricular aneurysm: clinical analysis].

Objective: To explore the clinical experiences, efficacies and postoperative left ventricular remodeling changes of surgical ventricular reconstruction in the treatment of post-infarction left ventricular aneurysm.

Methods: The investigators reviewed retrospectively the clinical data, operative approaches and follow-up outcomes of consecutive 194 patients with post-infarction left ventricular aneurysm, who underwent surgical ventricular reconstruction between January 1997 and December 2009. There were 54 cases in the linear group and 137 cases in the endoventricular patch plasty group.

[Clinical application of extracorporeal membrane oxygenation for severe heart failure during peri-operative period of end-stage cardiopathy].

Objective: To summarize the clinical effect and experience of extracorporeal membrane oxygenation (ECMO) support for severe heart failure during peri-operative period of end-stage cardiopathy.

Methods: From June 2007 to July 2010, 6 patients with severe heart failure during peri-operative period of end-stage cardiopathy received ECMO support. The changes in the hemodynamics and outcome of the patients during the use of ECMO were investigated.

Is the use of cardiopulmonary bypass for isolated coronary artery bypass an independent predictor of mortality and morbidity in patients with severe left ventricular dysfunction?

Background: Patients presenting with severe left ventricular dysfunction (SLVD) undergoing conventional coronary artery bypass grafting (CCABG) are at an increased risk of perioperative mortality and morbidity. The aim of this study was to assess the risk factors responsible for mortality and morbidity among patients with SLVD by comparing CCABG and off-pump coronary artery bypass surgery (OPCAB).

Methods: We retrospectively evaluated 186 consecutive patients with SLVD who underwent coronary artery bypass grafting (CABG), including 102 by CCABG and 84 by OPCAB.

[Stereological study on the myocardial protection in mitral valve replacement with beating heart under mild hypothermia].

Objective: To appraise objectively the myocardial protective effect of beating heart with mild hypothermia and cardiopulmonary bypass (CPB) with cardiac arrest by cold cardioplegia perfusion during open-heart operation for mitral valve replacement (MVR).

Methods: Forty patients with rheumatic heart disease were randomly allocated to two groups: (1) beating heart group: 20 cases of MVR with beating heart under mild hypothermia and CPB; (2) heart arrest group: 20 cases of MVR with heart arrest by using cold blood cardioplegia (CBC) and CPB. Samples of myocardium were obtained at 3 times points during CPB, and myocardial ultrastructure was observed and analysed for both groups.

Comparative study of on-pump and off-pump coronary bypass surgery in patients with triple-vessel coronary artery disease.

Background: Studies on selected patients undergoing off-pump versus on-pump coronary artery bypass surgery have produced inconsistent results, especially in patients with multiple coronary artery disease. This study compared the clinical results of on-pump and off-pump coronary bypass surgery in patients with triple-vessel disease.

Methods: A total of 300 consecutive isolated, multiple coronary artery bypass grafting (CABG) patients were assigned to the off-pump coronary artery bypass (OPCAB, n = 150) or CABG with cardiopulmonary bypass (CCABG, n = 150) groups.