Dexmedetomidine Attenuates Lung Injury in Toxic Shock Rats by Inhibiting Inflammation and Autophagy.

Objective: To explore the mechanisms whereby dexmedetomidine reversed lung injury in rats with toxic shock via inhibiting inflammation and autophagy.

Methods: Thirty-six specific pathogen-free male Sprague Dawley rats with were screened and randomly divided into three groups. Toxic shock was induced by intestinal leakage.

Associations of body weight and weight change with cardiovascular events and mortality in patients with coronary heart disease.

Background And Aims: It is recommended that patients with coronary heart disease (CHD) pursue a normal body weight, while the effects of body weight and weight change on prognosis are still controversial. The present study was to assess these effects using a large-scale population with CHD in China.

Methods: A total of 5276 patients with CHD were included from Jan 2000 to Dec 2014.

Inhibition of microRNA-34a protects against propofol anesthesia-induced neurotoxicity and cognitive dysfunction via the MAPK/ERK signaling pathway.

Aim: To investigate the protective effect of microRNA-34a (miR-34a) on propofol-induced neurotoxicity and cognitive dysfunction.

Methods: After SH-SY5Y cells were treated with propofol to induce neurotoxicity, microRNA-34a mimics and inhibitors were transfected into the cells. The expression of apoptosis-related genes and the proteins were measured by quantitative reverse transcription polymerase chain reaction (qRT-PCR) and western blot.

Effects of body mass index and weight change on mortality in older men with impaired glucose regulation.

Objectives: To assess the effect of baseline body mass index (BMI) status and weight change on mortality in older men with impaired glucose regulation (IGR).

Methods: Eight hundred eighty-five men with IGR aged 60 to 90 were included. Baseline and endpoint weight were measured.

[Influencing factors of glycemic variability in elderly patients with type 2 diabetes].

Objective: To explore the influencing factors of glycemic variability in elderly patients with type 2 diabetes.

Methods: A total of 337 elderly patients received continuous glucose monitoring (CGM) from January 2007 to January 2011. The evaluation variables of glycemic variability included standard deviation of blood glucose (SDBG), mean amplitude of glycemic excursion (MAGE), absolute means of daily differences (MODD) and postprandial glucose excursion (PPGE).

Influence of glycemic variability on the HbA1c level in elderly male patients with type 2 diabetes.

Objective: To investigate the influence of glycemic variability on the HbA1c level in elderly male patients with type 2 diabetes (T2DM).

Methods: The 24-h glucose profiles were obtained using a continuous glucose monitoring system in 291 elderly male type 2 diabetic patients. The relationship between the glycemic variability and HbA1c level was assessed in these patients.

[Analysis of essential oil from the leaves and fruits of Eucalyptus tereticornis in Guangxi province by GC-MS].

Objective: To Analyze the chemical composition and their relative contents of essential oil from the leaves and fruits of Eucalyptus tereticornis in Guangxi province.

Methods: The column temperature was controlled by a program with a capillary column HP-5 MS, and the MS analysis was performed with EI and quadrupole mass analyzer. The chemical compositions were identified by NIST98 searching and mass spectra comparing, and their relative contents were determined by using normalization method of chromatographic peak areas.

[Renin-angiotensin system in mesenteric adipose tissues in rats with metabolic syndrome].

Objective: To investigate the renin-angiotensin system (RAS) in mesenteric adipose tissues and effect of angiotensin II on adipocyte differentiation.

Methods: Thirty normal 8-week-old male Wistar rats were divided into groups on normal diet and high-fat diet. The rats on high-fat diet for 24 weeks developed the metabolic syndrome respectively.