Publications by authors named "Zhi-Bin Liao"
Article Synopsis
- Thioredoxin reductase 1 (TXNRD1) is found to be upregulated in hepatocellular carcinoma (HCC) and linked to poor patient survival, indicating its role in tumor development.
- Reducing TXNRD1 levels significantly slows down the growth and spread of HCC cells, while increasing its levels has the opposite effect, highlighting its importance in cancer progression.
- The study identifies USF2 as a suppressor of TXNRD1, which regulates its expression and, through the activation of Akt/mTOR signaling, contributes to the aggressiveness of HCC.
Increasing evidence has suggested that liver cancer arises partially from transformed hepatic progenitor cells (HPCs). However, the detailed mechanisms underlying HPC transformation are poorly understood. In this study, we provide evidence linking the coexistence of hepatitis B virus X protein (HBx) and transforming growth factor beta 1 (TGF-β1) with miR-199a-3p in the malignant transformation of HPCs.
View Article and Find Full Text PDFHepatocellular carcinoma (HCC) has a poor treatment prognosis and high mortality worldwide. Understanding the molecular mechanism underlying HCC development would benefit the identification of diagnostic biomarkers and the improvement of the treatment strategies. The expression of carboxypeptidase A6 (CPA6) has been reported in epilepsy and febrile seizures rather than in any type of cancers.
View Article and Find Full Text PDFBackground: Increasing evidence indicates that aberrant micro (mi)RNA-448 expression plays a critical role in the progression of several human cancers. However, the function of miRNA-448 in hepatocellular carcinoma (HCC) has not been fully investigated.
Methods: miRNA-448 expression levels in HCC tissues, adjacent non-cancerous tissues (ANTs), and HCC cell lines were examined by quantitative real-time polymerase chain reaction (qRT-PCR).