[Clinical efficacy of Manlyman Spray on premature ejaculation].

Objective: To observe the clinical effect of Manlyman Spray in the treatment of premature ejaculation (PE).

Methods: From January 2021 to March 2022, a total of 123 patients with PE were enrolled in clinical observation. Manlyman Spray was sprayed on the surface of the glans penis, corona of the glans and frenulum of the penis qd for 4 weeks.

[Cytogenetic and molecular analysis of a case of Prader-Willi syndrome].

Objective: To investigate the significance of cytogenetic and molecular genetic diagnosis of a special type of secondary sexual dysplasia and the applicability of various methods for its detection.

Methods: Using karyotype analysis, array comparative genomic hybridization (aCGH), multiplex ligation-dependent probe amplification (MLPA) and methylation-specific PCR (MS-PCR), we diagnosed and differentially diagnosed a case of secondary sexual dysplasia.

Results: Abnormalities were not found in the karyotype analysis or the SRY and AZF gene detection, nor chromosomal duplication and deletion in the initial SurePrint G3 Human CGH Array Kit8×60K.