Simultaneous separation and detection of common chiral and achiral metabolites in the urine of human exposed to benzene series by LC-MS/MS.

Benzene, toluene, and xylene (BTX) are priority pollutants known for their hematotoxicity and carcinogenic properties. Benzene is further metabolized to phenyl mercapturic acid (PMA), toluene and xylene also generate benzyl mercapturic acid (BMA) in human urine. To confirm whether the exposure to benzene series comes from the workplace or from the external environment such as smoking is a very meaningful work, so accurate measurement of their biomarkers in biological samples is crucial.

and in prostate cancer: from molecular pathways to therapeutic targets: a narrative review.

Background And Objective: Prostate cancer is a major cause of cancer-related morbidity and mortality in men globally. The pathogenesis involves complex interactions between genetic mutations and environmental factors, activating multiple signaling pathways, especially Wnt/β-catenin, PI3K/Akt, and NF-κB pathways. Tumor suppressor genes and are key inhibitors of these pathways, crucial in suppressing tumor growth and metastasis.

Effects of suspension exercise training in the treatment of lumbar disk herniation: a systematic review and meta-analysis.

Objective: The study aimed to systematically evaluate the efficacy of suspension exercise training (SET) in the treatment of lumbar intervertebral disk herniation and provide a scientific basis for clinical treatment.

Methods: Databases such as CNKI, Chinese Wanfang, PubMed, Cochrane, the Web of Science, and Embase were searched up to June 2024. A quality assessment was performed using the Cochrane Collaboration's risk-of-bias guidelines, and a meta-analysis was conducted using RevMan 5.

Comparison of postoperative survival prognosis between early-onset and late-onset esophageal cancer: A Population-based study.

The prognosis of non-distant metastatic early-onset esophageal cancer (EC) patients undergoing surgical treatment remains unclear, this study aims to compare the prognosis of early-onset and late-onset EC. Information on non-distant metastatic EC patients who underwent surgical treatment and were initially diagnosed between 2004 and 2015 was collected from the Surveillance, Epidemiology, and End Results (SEER) database. Propensity score matching (PSM) was used to balance the baseline differences between early-onset and late-onset EC patients.

Terahertz Wave Alleviates Comorbidity Anxiety in Pain by Reducing the Binding Capacity of Nanostructured Glutamate Molecules to GluA2.

Comorbid anxiety in chronic pain is clinically common, with a comorbidity rate of over 50%. The main treatments are based on pharmacological, interventional, and implantable approaches, which have limited efficacy and carry a risk of side effects. Here, we report a terahertz (THz, 10 Hz) wave stimulation (THS) technique, which exerts nonthermal, long-term modulatory effects on neuronal activity by reducing the binding between nano-sized glutamate molecules and GluA2, leading to the relief of pain and comorbid anxiety-like behaviors in mice.

Multi-omics analysis reveals indicator features of microbe-host interactions during colonization and subsequent infection.

Introduction: gastrointestinal (GI) colonization is crucial for the onset of invasive disease. This research encompassed 31 patients diagnosed with spp. bloodstream infections during their admission to a university hospital in China.

A recombinant L-threonine aldolase with high catalytic efficiency for the asymmetric synthesis of L-threo-phenylserine and L-threo-4-fluorophenylserine.

Objectives: To develop robust variants of L-threonine aldolases (L-TAs), potent catalysts for synthesizing asymmetric β-hydroxy-α-amino acids, it is necessary to identify critical residues beyond the known active site residues.

Results: Through virtual screening, a neglected residue Asn305, was identified as critical for catalytic efficiency. Subsequent site-saturation mutagenesis led to a potent variant N305R which exhibited excellent conversions of 88% (87%) and 80% (94%) for the synthesis of L-threo-phenylserine and L-threo-4-fluorophenylserine respectively.

Effect of γ-irradiation combined with enzymatic modification on the physicochemical properties of defatted rice bran dietary fiber.

This study comprehensively examines how combining γ-irradiation and enzymatic modification influences the microstructure and physicochemical properties of dietary fiber (DF) obtained from defatted rice bran. The resulting yields of soluble dietary fiber (SDF) and insoluble dietary fiber (IDF) were measured at 13.38 ± 0.

Fibular grafts in global reconstructive surgery: a bibliometric analysis.

Background: Over the past few decades, fibular grafts have been widely utilized across 86 countries and regions globally for surgical reconstruction of various anatomical sites, including the mandible, upper extremities, lower extremities, spine, and in phalloplasty procedures. The present study aims to systematically investigate the developmental trajectory of fibular graft and identify research priorities for surgeons.

Methods: A bibliometric analysis was conducted by searching the Web of Science Core Collection on April 12, 2024, for articles published between 2004 and 2023 on fibular grafting, using the query TS = ("graft" OR "transfer" OR "flap") AND TS = ("fibular").

Ovarian Ultrasound Image Segmentation Algorithm with Fused Multi-Scale Features.

Ultrasound imaging technology plays a vital role in medical imaging. Ovarian ultrasound image segmentation is challenging due to the wide variation in lesion sizes caused by the cancer detection period and individual differences, as well as the noise from reflected wave interference. To address these challenges, we propose an innovative algorithm for ovarian ultrasound image segmentation that incorporates multi-scale features.

LncRNA gene polymorphisms and their influence on lung cancer patients in the Chinese Han population.

Lung cancer is primarily classified as NSCLC, which is distinguished by a wide range of genetic variations. This study focused on , a relatively unexplored lncRNA, to explore the impact of its genetic polymorphisms on the susceptibility to NSCLC. We detected expression and its correlation with prognosis and clinical pathological features using bioinformatics analysis.

Integrated Materials Design and Process Engineering for n-Type Polymer Thermoelectrics.

Polymer thermoelectrics (TEs) have attracted increasing interest in recent years, owing to their great potential in intimate integration with wearable electronics for powering small electronics/sensors and personal temperature regulation. Over the past few decades, substantial progress has been made in enhancing polymer TE performance. However, the electrical conductivity and power factor of most n-doped polymers are about an order of magnitude lower than those of their p-type counterparts, impeding the development of highly efficient polymer TE devices.

Benefit evaluation of sloping land conversion program in the upper reaches of the Yellow River.

This study used forestry statistical data and field survey data from 2000 to 2018 to analyze the ecological restoration effect of the returning farmland to forest project in the upper reaches of the Yellow River, considering four perspectives, namely, project construction goals, ecosystem quality, ecosystem service functions, and ecological restoration driving factors. One-way ANOVA and logit regression analysis methods were used for comparison. The results show that the implementation of the Grain for Green Project has reduced the carrying capacity of rural land, effectively curbed the continuous deterioration of the ecological environment, and protected and benefited the forest ecosystem.

Finite element analysis of maxillary orthodontic therapies with variable alveolar bone grafts under occlusal forces in patient with unilateral cleft lip and palate.

Objective: To investigate the biomechanical effects of maxillary orthodontic treatment on different alveolar bone grafting positions loaded with occlusal forces in an unilateral cleft lip and palate (UCLP) patient.

Methods: Finite element analysis was employed to simulate clinical scenarios more accurately by loading with occlusal forces on 8 bone-grafted models during maxillary orthodontic treatment. Displacement and von Mises stress pattern during maxillary protraction, expansion, and combined protraction and expansion were analyzed.

DFT Study on the Mechanism of As(III) Oxidation in the Presence of Fe(II) and O.

In natural aquatic environments, the fate of arsenic (As) is significantly influenced by redox processes involving iron (Fe) species. Understanding the mechanisms governing As transformation in the presence of Fe species is crucial for comprehending its environmental impact and advancing remediation strategies. In this work, the oxidation of As(III) in oxygenated Fe(II) solutions was investigated.

Vascular endothelial growth factor pathway's influence on bevacizumab efficacy in metastatic colorectal cancer treatment.

In this article, an article published in the , which focuses on whether the expression of programmed death-ligand 1 (PD-L1) affects the effectiveness of chemotherapy regimens, including bevacizumab, in treating patients with colorectal cancer (CRC). Through neutralization of vascular endothelial growth factor (VEGF), bevacizumab inhibits tumor angiogenesis, impairing neovascularization and thereby depriving the tumor of essential nutrients and oxygen. Conversely, PD-L1 binding to VEGF receptor 2 promotes angiogenesis, supporting tumor vasculature.

Co-management enhances social capital and recognition of protected area: Perspectives from indigenous rangers on the Qinghai-Tibet Plateau.

Indigenous rangers play a critical role in achieving global biodiversity goals by facilitating effective conservation and community development. However, there is limited knowledge about rangers' livelihoods and responses to conservation policies. This study examined indigenous rangers' perceptions of livelihood impacts and attitudes toward national park management in Three-River-Source National Park (TRSNP).

DNA and RNA sequencing reveal the role of rare bacterial taxa in constructed wetlands: Insights into community activities, ecological functions, and assembly processes.

Microorganisms are essential for the functioning of constructed wetlands (CWs), yet the role of rare bacterial taxa in CWs remains poorly understood. In this study, the community structure, metabolic activities, ecological functions, and assembly processes of abundant and rare bacterial taxa in CWs were examined using DNA and RNA high-throughput sequencing. Our results revealed that Gammaproteobacteria, Alphaproteobacteria, Bacteroidia, and Actinobacteria exhibited high diversity and sequence abundance.

Evaluation and Optimization of Cement Slurry Systems for Ultra-Deep Well Cementing at 220 °C.

With the depletion of shallow oil and gas resources, wells are being drilled to deeper and deeper depths to find new hydrocarbon reserves. This study presents the selection and optimization process of the cement slurries to be used for the deepest well ever drilled in China, with a planned vertical depth of 11,100 m. The bottomhole circulating and static temperatures of the well were estimated to be 210 °C and 220 °C, respectively, while the bottomhole pressure was estimated to be 130 MPa.

Synergistic effects of anlotinib and DDP on breast cancer: targeting the VEGF/JAK2/STAT3 axis.

Background: Anlotinib, a highly selective inhibitor of VEGFR2, has demonstrated significant anti-tumor effects in various cancers. However, its potential synergistic effects with DDP (cisplatin) in breast cancer (BRCA) remain to be fully elucidated. This study aims to discover the therapeutic efficacy of anlotinib on BRCA, specifically the synergistic effects with DDP, and to elucidate the underlying molecular mechanisms.

m6A-methylase METTL3 promotes retinal angiogenesis through modulation of metabolic reprogramming in RPE cells.

Retinal neovascularization (RNV) disease is one of the leading causes of blindness, yet the molecular underpinnings of this condition are not well understood. To delve into the critical aspects of cell-mediated angiogenesis, we analyzed our previously published single-cell data. Our analysis revealed that retinal pigment epithelium (RPE) cells serve a crucial promotional function in angiogenesis.