Mutational Landscape of Gastric Adenocarcinoma of the Fundic Gland Type Revealed by Whole Genome Sequencing.

Background: Gastric adenocarcinoma of the fundic gland type (GA-FG) is a newly described variant of gastric adenocarcinoma with lack of knowledges regarding its genetic features.

Methods: We performed whole-genome sequencing (WGS) in formalin-fixed paraffin-embedded (FFPE) tumor tissues and matched adjacent noncancerous specimens from 21 patients with GA-FG, and integrated published datasets from 1105 patients with traditional gastric adenocarcinoma with the purpose of dissecting genetic determinants both common to conventional gastric adenocarcinoma and unique to GA-FG disease.

Results: We characterized the genomic architecture of GA-FG disease, revealing the predominant proportion of C > T substitution among the six types of SNVs.

Physics-informed neural network for lithium-ion battery degradation stable modeling and prognosis.

Accurate state-of-health (SOH) estimation is critical for reliable and safe operation of lithium-ion batteries. However, reliable and stable battery SOH estimation remains challenging due to diverse battery types and operating conditions. In this paper, we propose a physics-informed neural network (PINN) for accurate and stable estimation of battery SOH.

Dual RNA sequencing of and host cell transcriptomes reveals ontologically distinct host-pathogen interaction.

Unlabelled: is a highly successful pathogen that poses a substantial threat to human health. However, the dynamic interaction between and the human gastric epithelium has not been fully investigated. In this study, using dual RNA sequencing technology, we characterized a cytotoxin-associated gene A ()-modulated bacterial adaption strategy by enhancing the expression of ATP-binding cassette transporter-related genes, and , upon coculturing with human gastric epithelial cells.

Inherently Interpretable Physics-Informed Neural Network for Battery Modeling and Prognosis.

Lithium-ion batteries are widely used in modern society. Accurate modeling and prognosis are fundamental to achieving reliable operation of lithium-ion batteries. Accurately predicting the end-of-discharge (EOD) is critical for operations and decision-making when they are deployed to critical missions.

The effect of flexible obstacles with different thicknesses on explosion propagation of premixed methane-air in a confined duct.

The effect of flexible obstacles with varying thicknesses on the explosion characteristics of combustible gas in a simulated confined duct (cross section 80 mm × 80 mm, length 3 m) was experimentally investigated, aiming to reduce the huge losses caused by gas explosion accidents in the process industries and mining industries. In this paper, plant fiber membranes with an opening area of 0 and thicknesses of 0.105 mm, 0.

Impact of rhG-CSF on Clinical Efficacy and Immune Cell Subsets after Initial Induction Chemotherapy in AML.

Background: The impact of recombinant human granulocyte colony-stimulating factor (rhG-CSF) in acute myeloid leukemia (AML) is still controversial. The purpose of this study is to explore the impact of rhG-CSF administration on clinical efficacy and immune cell subsets after initial induction chemotherapy in AML.

Methods: The clinical efficacy and immune cell subsets were compared in the newly diagnosed patients with AML according to whether rhG-CSF was used after initial induction chemotherapy.

[Correlation between Peripheral Blood Intermediate Monocytes Increased and the Disease Progression of Patients with Diffuse Large BCell Lymphoma].

Unlabelled: AbstractObjective: To explore the distribution characteristics and clinical significance of peripheral blood monocyte subgroups in patients with diffuse large Bcell lymphoma(DLBCL).

Methods: The percentage of peripheral blood monocyte subsets of 82 DLBCL patients (including 32 newly diagnosis, 29 remission and 21 relapse) and 30 healthy controls were detected by flow cytometry, and the correlation with the clinical characteristics and its diagnostic value of DLBCL were analyzed.

Results: The proportion of intermediate monocytes in patients with newly diagnosed DLBCL group was higher than that in healthy controls (t=5.

Short-term Outcomes of Elective Surgery Following Self-Expandable Metallic Stent and Neoadjuvant Chemotherapy in Patients With Left-Sided Colon Cancer Obstruction.

Background: Colonic stenting reduces morbidity and stoma formation for left-sided colon cancer obstruction, and a prolonged interval between stenting and surgery with neoadjuvant chemotherapy administered might result in a lower stoma rate and tumor reduction.

Objective: The study aimed to evaluate the short-term outcomes of elective surgery following colonic stenting compared with elective surgery following colonic stenting and neoadjuvant chemotherapy in patients with left-sided colon cancer obstruction.

Design: This is a prospective multicenter cohort study.

Faecal microbiome and metabolic signatures in rectal neuroendocrine tumors.

The prevalence of rectal neuroendocrine tumors (RNET) has increased substantially over the past decades. Little is known on mechanistic alteration in the pathogenesis of such disease. We postulate that perturbations of human gut microbiome-metabolome interface influentially affect the development of RNET.

The application possibility of acellular dermal matrix decorated with nano-silver in the reconstruction of contaminated abdominal wall.

Acellular dermal matrix (ADM) is a biomaterial, which commonly used for repair of tissue defects; however, infection is the main factor underlying the failure of treatments involving ADM. To enhance the anti-infection ability of ADM, we constructed a new form of ADM that was decorated with nano-silver ('NS-ADM'). The introduction of nano-silver did not destroy the decellularized structure of ADM, and no significant difference was detected with regards to the maximum tensile force when compared between NS-ADM and ADM (P = 0.

Efficacy and safety of self-expanding metallic stent placement followed by neoadjuvant chemotherapy and scheduled surgery for treatment of obstructing left-sided colonic cancer.

Background: This study aimed to evaluate the safety and feasibility of self-expanding metallic stent (SEMS) followed by neoadjuvant chemotherapy prior to elective surgery for obstructing left-sided colon cancer.

Methods: Eleven consecutive patients with obstructing left-sided colon cancer between May 2014 and November 2015 were included retrospectively. All patients received SEMS followed by neoadjuvant chemotherapy.

Trans-perineal minimally invasive approach during extralevator abdominoperineal excision for advanced low rectal cancer: A retrospective cohort study.

Background: This study is to evaluate trans-perineal minimally invasive approach for extralevator abdominoperineal excision (TP-ELAPE) in a synchronous lithotomy position for locally advanced low rectal cancer.

Methods: Between May 2013 and February 2016, 14 patients with locally advanced low rectal cancer underwent TP-ELAPE for the perineal phase of extralevator abdominoperineal excision, and 18 patients underwent conventional ELAPE.

Results: There was no positive circumferential resection margin in both groups.

Perineal Wound Complications After Extralevator Abdominoperineal Excision for Low Rectal Cancer.

Background: Reconstruction of the pelvic floor defect caused by extralevator abdominoperineal excision poses a challenge for the surgeon.

Objective: The aim of this study was to analyze the long-term perineal wound complications in patients undergoing conventional primary closure versus biological mesh-assisted repair after extralevator abdominoperineal excision.

Design: This was a single-institution retrospective observational study.

Homogenization and Localization of Ratcheting Behavior of Composite Materials and Structures with the Thermal Residual Stress Effect.

In this contribution, the ratcheting behavior and local field distribution of unidirectional metal matrix composites are investigated under cyclic loading. To that end, we extended the finite-volume direct averaging micromechanics (FVDAM) theory by incorporating the rule of nonlinear kinematic hardening. The proposed method enables efficient and accurate simulation of the ratcheting behavior of unidirectional composites.

Evaluate the Fatigue Life of CFRC Subjected to Coupled Thermo-Mechanical Loading.

Mechanical properties of composites manufactured by high-temperature polymer polyether ether ketone (PEEK) with continuous reinforced fibers are closely dependent on ambient temperature variations. In order to effectively study fatigue failure behaviors of composites under the coupled thermo-mechanical loading, a well-established microscopic model based on a representative volume element (RVE) is proposed in this paper. Stiffness degradation behaviors of the composite laminates at room and elevated temperatures are firstly investigated, and their failure strengths are compared with experimental data.

Treating cardiovascular atherosclerotic plaques with Tongmaijiangzhi (TMJZ) capsule.

Atherosclerotic plaques can cause serious syndromes and mortality. Cholesterol accumulation in the plaques can disrupt the arterial flow, with lumen narrowing and stenosis, which contributes to heart attack and sudden cardiac death. The pharmacological treatment to atherosclerotic plaques can be anti-hypertensives, anti-cholesterol, and cleaning of the existed plaques.

Biaxial yield surface investigation of polymer-matrix composites.

This article presents a numerical technique for computing the biaxial yield surface of polymer-matrix composites with a given microstructure. Generalized Method of Cells in combination with an Improved Bodner-Partom Viscoplastic model is used to compute the inelastic deformation. The validation of presented model is proved by a fiber Bragg gratings (FBGs) strain test system through uniaxial testing under two different strain rate conditions.