Postoperative complications after robotic resection of colorectal cancer: An analysis based on 5-year experience at a large-scale center.

Background: As a common gastrointestinal malignancy, colorectal cancer (CRC) poses a serious health threat globally. Robotic surgery is one of the future trends in surgical treatment of CRC. Robotic surgery has several technical advantages over laparoscopic surgery, including 3D visualization, elimination of the fulcrum effect, and better ergonomic positioning, which together lead to better surgical outcomes and faster recovery.

Role of minimally invasive techniques in gastrointestinal surgery: Current status and future perspectives.

In recent years, the incidence of gastrointestinal cancer has remained high. Currently, surgical resection is still the most effective method for treating gastrointestinal cancer. Traditionally, radical surgery depends on open surgery.

CD4 T cell depletion does not affect the level of viremia in chronically SHIV-infected Chinese cynomolgus monkeys.

Chronically SHIV-infected cynomolgus monkeys were used to determine the effects of the antibody-mediated acute CD4 T cell depletion on viral load as well as on the immunological factors associated with disease progression. Compared with the control animals, CD4 T cell-depleted animals with SHIV infection showed (i) little alteration in plasma viral load over the period of 22 weeks after the depletion; (ii) increased CD4 T cell proliferation and turnover of macrophages at the early phase of the depletion, but subsequent decline to the basal levels; and (iii) little impact on the expression of the inflammatory cytokines and CC chemokines associated with disease progression. These findings indicate that the antibody-mediated acute CD4 T cell depletion had minimal impact on plasma viral load and disease progression in chronically SHIV-infected cynomolgus monkeys.

Calcitriol enhances pyrazinamide treatment of murine tuberculosis.

Background: Tuberculosis is a leading cause of morbidity and mortality in humans worldwide. There is an urgent need for new and effective drugs to treat tuberculosis and shorten the duration of tuberculosis therapy. 1, 25-dihydroxy vitamin D3 (1,25 (OH)2D3) has been reported to have a synergistic effect with pyrazinamide (PZA) in killing tubercle bacilli in vitro.

Lumbar bone erosion with anterior dural ectasia in ankylosing spondylitis: a case report.

Bony erosion and dural ectasia rarely occur in the posterior part of the vertebral body in ankylosing spondylitis (AS). Because of the compression of nerve tissue that adheres to the inflamed dura mater, a range of neurologic symptoms may develop. Few studies have investigated therapies for this condition, and surgical intervention might alleviate the neurologic dysfunction.

Clinical and MRI response to dose reduction of an etanercept-biosimilar for hip arthritis in patients with ankylosing spondylitis: an observational, retrospective cohort study.

Objectives: Hip arthritis plays a critical role in the prognosis of ankylosing spondylitis (AS). Dose reduction of tumor necrosis factor inhibitors preserves general improvement of AS, so this study attempted to examine the equivalence between Yisaipu® tapering and conventional therapy for hip arthritis in AS patients, using clinical parameters and magnetic resonance image (MRI).

Methods: AS patients received this etanercept-biosimilar injections (50 mg/week) in the first 12 weeks.

Flexible and Accurate Simulation of Radiation Cooling with FETD Method.

Thermal management and simulation are becoming increasingly important in many areas of engineering applications. There are three cooling routes for thermal management, namely thermal conduction, thermal convection and thermal radiation, among which the first two approaches have been widely studied and applied, while the radiation cooling has not yet attracted much attention in terrestrial environment because it usually contributes less to the total amount of thermal dissipation. Thus the simulation method for radiation cooling was also seldom noticed.

The deubiquitinating enzyme cylindromatosis mitigates nonalcoholic steatohepatitis.

Nonalcoholic steatohepatitis (NASH) is a common clinical condition that can lead to advanced liver diseases. Lack of effective pharmacotherapies for NASH is largely attributable to an incomplete understanding of its pathogenesis. The deubiquitinase cylindromatosis (CYLD) plays key roles in inflammation and cancer.

Nontopotactic Reaction in Highly Reversible Sodium Storage of Ultrathin Co Se /rGO Hybrid Nanosheets.

Transition metal chalcogenide with tailored nanosheet architectures with reduced graphene oxide (rGO) for high performance electrochemical sodium ion batteries (SIBs) are presented. Via one-step oriented attachment growth, a facile synthesis of Co Se nanosheets anchored on rGO matrix nanocomposites is demonstrated. As effective anode materials of SIBs, Co Se /rGO nanocomposites can deliver a highly reversible capacity of 406 mA h g at a current density of 50 mA g with long cycle stability.

SIV Infection Facilitates Infection of Rhesus Macaques.

Tuberculosis (TB) is a common opportunistic infection and the leading cause of death for human immunodeficiency virus (HIV)-infected patients. Thus, it is necessary to understand the pathogenetic interactions between and HIV infection. In this study, we examined and/or simian immunodeficiency virus (SIV) infection of Chinese rhesus macaques.

Unlocking the potential of SnS: Transition metal catalyzed utilization of reversible conversion and alloying reactions.

The alloying-dealloying reactions of SnS proceeds with the initial conversion reaction of SnS with lithium that produces LiS. Unfortunately, due to the electrochemical inactivity of LiS, the conversion reaction of SnS is irreversible, which significantly limit its potential applications in lithium-ion batteries. Herein, a systematic understanding of transition metal molybdenum (Mo) as a catalyst in SnS anode is presented.

Three-dimensional hierarchical NiCo2O4 nanowire@Ni3S2 nanosheet core/shell arrays for flexible asymmetric supercapacitors.

Three-dimensional (3D) hierarchical NiCo2O4@Ni3S2 core/shell arrays on Ni foam were synthesized by a facile, stepwise synthesis approach. The 3D heterogeneous NiCo2O4 nanostructure forms an interconnected web-like scaffold and serves as the core for the Ni3S2 shell. The as-prepared NiCo2O4@Ni3S2 nanowire array (NWA) electrodes exhibited excellent electrochemical performance, such as high specific areal capacitance and excellent cycling stability.

Chiral copper(II) complex based on natural product rosin derivative as promising antitumour agent.

To evaluate the biological preference of chiral drug candidates for molecular target DNA, the synthesis and characterization of a chiral copper(II) complex (2) of a chiral ligand N,N'-(pyridin-2-ylmethylene) dehydroabietylamine (1) was carried out. The interactions of 1 and 2 with salmon sperm DNA were investigated by viscosity measurements, UV, fluorescence and circular dichroism (CD) spectroscopic techniques. Absorption spectral, emission spectral and viscosity analysis reveal that 1 and 2 interacted with DNA through intercalation and 2 exhibited a higher DNA binding ability.

Asymmetric supercapacitors with high energy density based on helical hierarchical porous Na MnO and MoO.

Helical hierarchical porous Na MnO/CC and MoO/CC, which are assembled from nanosheets and nanoparticles, respectively, are fabricated using a simple electrodeposition method. These unique helical porous structures enable electrodes to have a high capacitance and an outstanding cycling performance. Based on the helical Na MnO/CC as the positive electrodes and helical MoO/CC as the negative electrodes, high performance Na MnO/CC//MoO/CC asymmetric supercapacitors (ASCs) are successfully assembled, and they achieve a maximum volume of 2.

Designed hybrid nanostructure with catalytic effect: beyond the theoretical capacity of SnO2 anode material for lithium ion batteries.

Transition metal cobalt (Co) nanoparticle was designed as catalyst to promote the conversion reaction of Sn to SnO2 during the delithiation process which is deemed as an irreversible reaction. The designed nanocomposite, named as SnO2/Co3O4/reduced-graphene-oxide (rGO), was synthesized by a simple two-step method composed of hydrothermal (1(st) step) and solvothermal (2(nd) step) synthesis processes. Compared to the pristine SnO2/rGO and SnO2/Co3O4 electrodes, SnO2/Co3O4/rGO nanocomposites exhibit significantly enhanced electrochemical performance as the anode material of lithium-ion batteries (LIBs).

Catalyst engineering for lithium ion batteries: the catalytic role of Ge in enhancing the electrochemical performance of SnO2(GeO2)0.13/G anodes.

The catalytic role of germanium (Ge) was investigated to improve the electrochemical performance of tin dioxide grown on graphene (SnO(2)/G) nanocomposites as an anode material of lithium ion batteries (LIBs). Germanium dioxide (GeO(20) and SnO(2) nanoparticles (<10 nm) were uniformly anchored on the graphene sheets via a simple single-step hydrothermal method. The synthesized SnO(2)(GeO(2))0.

3D graphene supported MoO2 for high performance binder-free lithium ion battery.

In this work, we report the synthesis of MoO2 nanoparticles grown on three dimensional graphene (3DG) via the reduction of α-MoO3 nanobelts through a facile chemical vapor deposition (CVD) approach under argon protection gas environment. In this synthesis approach, the presence of hydrophobic 3DG promoted the Volmer-Weber growth of MoO2 nanoparticles (30-60 nm). The as-prepared MoO2-3DG nanocomposite was directly used as a binder-free anode electrode for lithium ion batteries (LIBs) without additives and exhibited excellent electrochemical performance.

[Efficacy of local injection of RhTNFR: Fc in collagen-induced arthritis of rats].

Objective: To evaluate the efficacy of recombinant human tumor necrosis factor-α receptor II: IgG fusion protein (RhTNFR:Fc) local injection in collagen-induced arthritis (CIA) of rats.

Methods: Twenty-four CIA rats were randomly divided into 3 groups: single therapy (Group I), multiply therapies (Group II) and control (Group III). Group I received normal saline thrice after a single RhTNFR:Fc local treatment while Groups II and III had 4 times of RhTNFR:Fc or normal saline local injection.

[Establishment and evaluation of a Chinese rhesus model of tuberculosis].

Objective: To establish and evaluate the Chinese rhesus model of tuberculosis.

Methods: Twelve Chinese rhesus macaques, randomly divided into 3 groups, were inoculated with 2 different doses of Mycobacterium tuberculosis H(37) Rv strain via both bronchoscopic and intratracheal instillation into the lungs. Clinical observation and laboratory examinations were performed, including erythrocyte sedimentation rate, C-reactive protein, tuberculin skin test and X-ray examination.

Azithromycin inhibits neutrophil accumulation in airways by affecting interleukin-17 downstream signals.

Background: Azithromycin can reduce neutrophil accumulation in neutrophilic pulmonary diseases. However, the precise mechanism behind this action remains unknown. Our experiment assessed whether azithromycin inhibits neutrophil accumulation in the airways by affecting interleukin-17 (IL-17) downstream signals.

[Expressions of CD147 in peripheral monocytes and T lymphocytes of patients with ankylosing spondylitis].

Objective: To investigate the roles of CD147 in the pathogenesis and development of ankylosing spondylitis (AS).

Methods: Flow cytometry was used to detect the expression levels of CD147 in peripheral monocytes and T lymphocytes of 30 AS patients, 30 rheumatoid arthritis (RA) patients and 30 healthy controls (HC). reverse transcription-polymerase chain reaction (RT-PCR) was used to evaluate the expression levels of CD147 mRNA in peripheral blood mononuclear cells (PBMC).

M. tuberculosis H37Rv infection of Chinese rhesus macaques.

Mycobacterium tuberculosis is the most common communicable infectious disease worldwide and the top killer of human immunodeficiency virus (HIV)-infected people. Because of common dual HIV and M. tuberculosis infections, the emergence of multidrug-resistant M.