Publications by authors named "Zhi Lei Zhang"

Background: A Disintegrin And Metalloproteinase 8 (ADAM8) has been implicated in the development and progression of several cancers. However, further studies are needed to determine the value of ADAM8 in ccRCC. The research aimed to investigate the prognostic and immunologic significance of ADAM8 in ccRCC from the perspective of bioinformatics.

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  • - The study analyzed clinical data from 112 penile cancer patients treated at Weifang People's Hospital between 2013 and 2023 to identify risk factors impacting cancer-specific survival (CSS) post-surgery.
  • - Results showed that the 1-, 3-, and 5-year CSS rates were 78.2%, 66.1%, and 63.7%, respectively, with a higher neutrophil-to-lymphocyte ratio (NLR) significantly linked to lower CSS rates.
  • - Key independent risk factors for poor prognosis included high NLR, older age, occupation type (farmer or worker), lower education, and certain preoperative blood ratio and fibrinogen levels.
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Background: The consistency of pancreatic apparent diffusion coefficient (ADC) values and intravoxel incoherent motion (IVIM) parameter values across different magnetic resonance imaging (MRI) devices significantly impacts the patient's diagnosis and treatment.

Aim: To explore consistency in image quality, ADC values, and IVIM parameter values among different MRI devices in pancreatic examinations.

Methods: This retrospective study was approved by the local ethics committee, and informed consent was obtained from all participants.

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Fabry disease (FD), an X-linked disorder resulting from dysfunction of α-galactosidase A, can result in significant complications. Early intervention yields better outcomes, but misdiagnosis or delayed diagnosis is common, impacting prognosis. Thus, early detection is crucial in the clinical diagnosis and treatment of FD.

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Background: Newborn genetic screening (NBGS) based on next-generation sequencing offers enhanced disease detection and better detection rates than traditional newborn screening. However, challenges remain, especially around reporting the NBGS carrier results. Therefore, we aimed to investigate the NBGS carrier parents' views on NBGS and NBGS reports in China.

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Background: Surgical resection remains the primary treatment for hepatic malignancies, and intraoperative bleeding is associated with a significantly increased risk of death. Therefore, accurate prediction of intraoperative bleeding risk in patients with hepatic malignancies is essential to preventing bleeding in advance and providing safer and more effective treatment.

Aim: To develop a predictive model for intraoperative bleeding in primary hepatic malignancy patients for improving surgical planning and outcomes.

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Background: Newborn genetic screening (NBGS) is promising for early detection of genetic diseases in newborns. However, little is known about its clinical effectiveness in special groups like high-risk infants. To address this gap, we aimed to investigate the impact of NBGS on high-risk infants.

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  • The study examined the link between semaphorin 4D (SEMA4D) levels and the prognosis of melanoma patients who also have liver cancer, involving a sample of 272 patients with recorded clinical data.
  • Statistical analyses revealed a significant correlation between prognosis and factors like age, tumor grade, and SEMA4D expression; specifically, older patients, those with higher tumor grades, and lower SEMA4D expression had poorer outcomes.
  • Survival analysis indicated that older patients and those with low SEMA4D levels had significantly shorter survival times compared to younger patients and those with higher SEMA4D expression, underscoring the potential of SEMA4D as a prognostic marker.
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Background And Aims: In recent years, more and more inflammatory indicators have been studied to predict the long-term survival of patients with ampullary carcinoma (AC) after radical resection, but these prognostic indicators are still controversial. Therefore, based on previous inflammation scores, this study established a novel, easily accessible, more feasible and more predictive prognostic marker [Carbohydrate antigen199 to gamma-glutamyltransferase ratio (CA19-9/GGT)] to better assess the prognostic significance in AC patients undergoing radical resection.

Methods: Overall survival (OS) and recurrence-free survival (RFS) were analyzed by Cox regression model.

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  • Newborn Genetic Screening (NBGS) was developed to improve upon the limitations of traditional Newborn Screening (NBS), specifically addressing issues of false positives/negatives and covering more genetic diseases.
  • A survey conducted in Nanjing collected 1141 valid responses, revealing that 86.68% of participants supported NBGS, with a significant portion willing to pay for it based on their household income.
  • The study highlighted a general acceptance of NBGS, particularly among more educated individuals, but also pointed out the need for better understanding of genetic conditions in less educated populations.
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  • Most complex renal stones are treated with percutaneous nephrolithotomy (PCNL), but navigating adjacent structures is challenging for surgeons, highlighting the need for new techniques.
  • The study evaluated the Hisense computer-assisted surgery (CAS) system in PCNL with 60 patients, comparing a CAS group using 3D models to a control group using standard techniques.
  • Results showed that the CAS group had significantly higher success rates for puncturing attempts (90% vs. 67%) and initial stone-free rates (87% vs. 63%), but no significant differences in operation time, hemoglobin changes, or complication rates.
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Background: Currently, change in pelvic incidence (PI) in patients after spinal surgery have not been associated with clear clinical symptoms. This study sought to compare changes in the sagittal parameters of different patients before and after thoracolumbar spine surgery, the relationship between PI change and sacroiliac joint pain (SIJP) after surgery was clarified, and the correlation between PI change and sacroiliac joint (SIJ) activity was verified.

Methods: This study retrospectively analyzed the data of patients who underwent thoracolumbar fusion at Sun Yat-sen Memorial Hospital from January 2019 to June 2021.

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Tumor necrosis factor-α-induced protein-8 like-2 (TIPE2) as a novel negative immune regulator plays an important role in several human diseases. However, its influences in cervical cancer and preeclampsia (PE) remain unclear. This study aims to explore the important role of TIPE2 in cervical cancer and PE via regulating cell invasion.

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Due to the potential engineering needs, the passive tunable metasurfaces with a high performance equivalent to the active phased array is worthy of research. Here, a passive ultrathin metasurface unit composed of a piezoelectric composite structure (PCS) connected to an external capacitor, which can modulate the phase of the transmitted acoustic waves at a deep subwavelength scale only by controlling the external capacitor but without changing the structure, is proposed. Then, a tunable acoustic metasurface composed of 20 identical PCSs is introduced to realize three acoustic functions, beam steering, beam focusing, and tweezer-like beam generating, just by changing the external capacitors.

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Newborn screening can detect around 40 different diseases based on biochemical indicators and has resulted in the improved quality of life for children suffering from genetic diseases. However, NBS is limited as it does not cover all genetic diseases in newborns and has high rates of false positives and negatives. Genetic screening can be used to address the shortcomings of traditional biochemical screening, however, the comprehensive clinical value of genetic screening is yet to be systematically studied.

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Post-stroke depression(PSD) is a common complication and associates with poor physical recovery, low quality of life and high mortality after cerebral infarction. However, the pathogenesis of PSD have not been elucidated thoroughly now, and there is a lack of effective therapy in clinic. It reported that Saikosaponin A, one of the main constituents from Chinese herb Bupleurum chinense, has pharmacological activity in anti-depression.

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Introduction: Intrahepatic cholangiocarcinoma (ICC) exhibited increasing incidence and mortality around the world, with a 35% five-year survival rate. In this study, the genetic alteration of primary ICC and metastasis ICC was exhibited to discover novel personalized treatment strategies to improve the clinical prognosis.

Methods: Based on 153 primary and 49 metastasis formalin-fixed paraffin-embedded ICC samples, comprehensive genomic profiling was carried out.

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Background: Postoperative morbidity of pancreaticoduodenectomy (PD) is still prevalent in hospitals around the world all over the world. Chirurgia B and Chen Yingtai compared the existing POSSUM and p-POSSUM scoring system in pancreatoduodenectomy. However, in this retrospective cohort study our aim was to investigate the risk factors associated with post-PD complications, and develop a POSSUM scoring system more specific to PD, which we define as PD-POSSUM.

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Axon regeneration after cerebral ischemia in mammals is inadequate to restore function, illustrating the need to design better strategies for improving outcomes. Improvement of axon regeneration has been achieved through fastigial nucleus electrostimulation (FNS) in animal researches. However, the mechanisms underlying this neuroprotection remain poorly understood.

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This study intends to explore the effect of the PAK1 gene silencing on apoptosis and proliferation of hepatocellular carcinoma (HCC) MHCC97-H and HepG2 cells and cells in xenograft tumor. MHCC97-H and HepG2 cells and mice with xenograft tumor in vivo were randomly divided into control, empty vector and PAK1 shRNA groups. Morphology and the expression of green fluorescent protein of MHCC97-H and HepG2 cells and cells in xenograft tumor were observed.

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Poly- and perfluorinated compounds (PFCs), which have been detected worldwide in human blood, surface water and house dust, are suspected to induce potential endocrine-disrupting hormonal effects. In this study, cell-based reporter gene assays were used to determine the activity of a variety of PFCs against the human pregnane X receptor (hPXR) to identify the critical structural feature of PFCs related to their hPXR activity. Molecular docking studies combined with site-directed mutagenesis were employed to investigate the mechanism by which PFCs interact with and activate hPXR.

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Perisaccadic spatial distortion (PSD) occurs when a target is flashed immediately before the onset of a saccade and it appears displaced in the direction of the saccade. In previous studies, the magnitude of PSD of a single target was affected by multiple experimental parameters, such as the target's luminance and its position relative to the central fixation target. Here we describe a contextual effect in which the magnitude of the PSD for a target was influenced by the synchronous presentation of another target: PSD for simultaneously presented targets was more uniform than when each was presented individually.

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When an object is viewed binocularly, unequal perspective projections of the two eyes' half images (binocular disparity) provide a cue for the sensation of stereo depth. For almost 200 years, binocular disparity has remained synonymous with retinal disparity, which is computed by subtracting the distance of each half image from its respective fovea. However, binocular disparity could also be coded in headcentric instead of retinal coordinates, by combining eye position and retinal image position in each eye and representing disparity as differences between visual directions of half images relative to the head.

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Visual directions of foveal targets flashed just prior to the onset of a saccade are misperceived as shifted in the direction of the eye movement. We examined the effects of luminance level and temporal interactions on the amplitude of these perisaccadic spatial distortions (PSDs). PSDs were larger for both single and sequentially double-flashed stimuli with low than high luminance levels, and there was a reduction of PSDs for low luminance targets flashed immediately before the saccade.

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