Objectives: Multiple factors associated with neural tube defects (NTDs) risk have been identified, yet there is little evidence on the possible effects of maternal stressful life events. In this study, we aimed to investigate the association between stressful life events during the periconceptional period and risk of NTDs in offspring.
Methods: Relevant literature was searched in PubMed, Springer Link, ScienceDirect, and Cochrane Library up to July 2023.