Publications by authors named "Zhi Jing Ma"
Article Synopsis
- A randomized, double-blind, phase 2 trial assessed the safety and effectiveness of a new vaccine, NVSI-06-09, as a booster for UAE adults previously vaccinated with BBIBP-CorV.
- * The trial involved 516 participants who received either NVSI-06-09 or continued with BBIBP-CorV, showing a similar low incidence of mild adverse reactions in both groups.
- * Results indicated that NVSI-06-09 produced significantly higher neutralizing antibody levels against various SARS-CoV-2 variants, including significantly better responses against Omicron strains compared to BBIBP-CorV.
The continuous emergence of SARS-CoV-2 variants highlights the need of developing vaccines with broad protection. Here, according to the immune-escape capability and evolutionary convergence, the representative SARS-CoV-2 strains carrying the hotspot mutations were selected. Then, guided by structural and computational analyses, we present a mutation-integrated trimeric form of spike receptor-binding domain (mutI-tri-RBD) as a broadly protective vaccine candidate, which combined heterologous RBDs from different representative strains into a hybrid immunogen and integrated immune-escape hotspots into a single antigen.
View Article and Find Full Text PDF[Studies on chemical constituents from stem barks of Fraxinus paxiana].
Zhongguo Zhong Yao Za Zhi
August 2008
Objective: To investigate the chemical constituents of Fraxinus paxiana.
Method: The chemical constituents were isolated and purified by chromatographic techniques and the structures of the compounds were identified with or by spectroscopic methods.
Result: Fifteen compounds were obtained from the methanol extract of F.
Objective: To investigate the effects of processing adjuvants-different types of processing vinegar on effective constituents in rhizoma of Corydalis yanhusuo, and evaluate the quality of different types of vinegar in China.
Method: The HPLC method was adopted to determine the extraction solubility of dl-tetrahydropalmation and total alkaloids in rhizoma of Corydalis yanhusuo processed by vinegar. The sample extracts were separated on kromasil ODS column with mobile phase of methanol-1% phosphoric acid solution(65:35) and detection wavelength was 280 nm.
[Determination of synephrine and N-methyltyramine in Pericarpium Citri Reticulatae viride by HPLC].
Zhongguo Zhong Yao Za Zhi
June 2004
Objective: To establish a quantitative method for determination of synephrine and N-methyltyramine in Citri Reticulatae.
Method: Samples were extracted with 30% methanol. ODS column was used with methanol-water-sodium dodecyl sulfate (55:45:0.