Explore the key targets and mechanism of Danggui Buxue decoction against ulcerative colitis: Network pharmacology and experimental validation.

Ethnopharmacological Relevance: The traditional Chinese herbal formula, Danggui Buxue decoction (DBD), is known for its ability in tonifying Qi and promoting the production of blood. It is extensively utilized in treating menstrual anemia and chronic non-healing ulcers. Whereas the impact of DBD on ulcerative colitis (UC) has not been explored, and its therapeutic mechanisms are not well comprehended.

Advances in understanding and management of IgG4-related ophthalmic disease.

Immunoglobulin G4-related ophthalmic disease (IgG4-ROD) is an emerging, immune-mediated fibroinflammatory orbital disease, characterized by tumefactive lesions with noticeable IgG4+ plasma cell infiltration and distinctive pathohistological features. This disease is often associated with elevated serum IgG4 concentrations. IgG4-ROD may affect any ophthalmic tissues, particularly the lacrimal gland, extraocular muscles, and trigeminal nerves.

Computer-Aided Diagnosis of Laryngeal Cancer Based on Deep Learning with Laryngoscopic Images.

Laryngeal cancer poses a significant global health burden, with late-stage diagnoses contributing to reduced survival rates. This study explores the application of deep convolutional neural networks (DCNNs), specifically the Densenet201 architecture, in the computer-aided diagnosis of laryngeal cancer using laryngoscopic images. Our dataset comprised images from two medical centers, including benign and malignant cases, and was divided into training, internal validation, and external validation groups.

[Application of Rat Model of Neurotic Erectile Dysfunction in Experiment].

Erectile dysfunction (ED) refers to the persistent inability to achieve and/or maintain a sufficient erection of the penis to obtain a satisfactory sexual life,which affects the quality of life of the patients and their sexual partners.To decipher the pathophysiological mechanism of ED,researchers have established a variety of animal models and achieved a series of progress.The cavernous nerve (CN) of rodents,anatomically similar to that of humans,is cost-effective,thick,and easy to be identified,which has gradually become the mainstream of animal models.

Molecular mechanism of di-n-butyl phthalate promotion of bladder cancer development.

Purpose: To determine whether di-n-butyl phthalate (DBP) promotes the occurrence of bladder cancer (BCa) and explore the action of DBP acts on BCa cells at the cellular and molecular levels.

Methods: MTT and Transwell assays were used to investigate the tumorigenic actions of DBP on BCa cells. Second-generation sequencing was used to identify differences in gene expression before and after DBP treatment.

A Multi-Center, Randomized, Blind, Controlled Clinical Trial of the Safety and Efficacy of Micro Radio Frequency Therapy System for the Treatment of Overactive Bladder.

Purpose: The purpose of this study was to evaluate the efficacy and safety of low power micro radiofrequency (RF) therapy (μRFthera) through urethra in the treatment of overactive bladders (OAB) through a prospective, single-blind, placebo-controlled, multi-center clinical protocol.

Materials And Methods: One hundred and fourteen patients with refractory OAB were randomized at 2:1 ratio, treatment to control undergoing same procedures except only the micro-RF treatment group at turned "on" setting in energy. Bladder diaries recorded during the screening period (3 days before enrollment) and during follow-up period on week 1, 3, and 7, respectively.

Hypoxia-inducible factor protects against acute kidney injury via the Wnt/β-catenin signaling pathway.

Promoting adaptive repair in acute kidney injury (AKI) is an effective strategy to prevent the progression from AKI to chronic kidney disease. However, the mechanisms involved in renal repair after AKI remain unclear. In this study, we investigated the role of hypoxia-inducible factor (HIF), an important regulator of ischemic and hypoxic injury, in AKI during the repair phase.

Bioinformatic Analysis Combined With Experimental Validation Reveals Novel Hub Genes and Pathways Associated With Focal Segmental Glomerulosclerosis.

Focal segmental glomerulosclerosis (FSGS) is a type of nephrotic syndrome leading to end-stage renal disease, and this study aimed to explore the hub genes and pathways associated with FSGS to identify potential diagnostic and therapeutic targets. We downloaded the microarray datasets GSE121233 and GSE129973 from the Gene Expression Omnibus (GEO) database. The datasets comprise 25 FSGS samples and 25 normal samples.

Roxadustat treatment for anemia in peritoneal dialysis patients: A randomized controlled trial.

Background/purpose: Roxadustat, a first-in-class hypoxia-inducible factor prolyl hydroxylase inhibitor, promotes erythropoiesis and regulates iron metabolism. This study investigated the efficacy and safety of roxadustat in Chinese patients with anemia on peritoneal dialysis (PD).

Methods: One hundred and twenty-nine patients were randomized and treated with roxadustat (n = 86) or erythropoiesis-stimulating agents (ESAs) (n = 43) for 24 weeks.

Clinical outcomes of sacral neuromodulation in non-neurogenic, non-obstructive dysuria: A 5-year retrospective, multicentre study in China.

Background: Management of non-neurogenic, non-obstructive dysuria represents one of the most challenging dilemmas in urological practice. The main clinical symptom is the increase in residual urine. Voiding dysfunction is the main cause of dysuria or urinary retention, mainly due to the decrease in bladder contraction (the decrease in contraction amplitude or duration) or the increase in outflow tract resistance.

[Effects of Different Concentrations of Ammonia Nitrogen on the Growth and Enzyme Activity of Four Common Algae Strains].

Treating swine wastewater with a high ammonia nitrogen content with microalgae cultures has proved difficult. In this paper, the strains , , , and were tested. Ammonia nitrogen concentrations of 50 mg·L, 500 mg·L, and 2000 mg·L applied to the media according to the concentrations of biogas slurry.

Results of Sacral Neuromodulation Therapy for Urinary Voiding Dysfunction: Five-Year Experience of a Retrospective, Multicenter Study in China.

Purpose: This five-year, retrospective, multicenter study evaluated the long-term safety and efficiency of sacral neuromodulation (SNM) in Chinese patients with urinary voiding dysfunction.

Patients And Methods: This is a Chinese national, multicenter, retrospective study that included 247 patients (51.2% female) who received an implantable pulse generator (IPG) (InterStim, Medtronic, Minneapolis, MN, USA) between 2012 and 2016.

[Efficacy of Huang'e Capsules on benign prostatic hyperplasia with Qi-deficiency, blood stasis and damp heat block: A stratified analysis].

Objective: To evaluate the efficacy and safety of Huang'e Capsules in the treatment of BPH with Qi-deficiency, blood stasis and damp heat block.

Methods: This study included 1 456 cases of BPH with Qi-deficiency, blood stasis and damp heat block from 40 hospitals of Zhejiang and Anhui Provinces between June 2014 and July 2017. The patients were aged 40－85 years and treated with Huang'e Capsules at a dose of 4 capsules, tid, for a course of 6 weeks.

[Hypospadias induced by maternal exposure to di-n-butyl phthalate and its mechanisms in male rat offspring , , , , ,].

Objective: To induce hypospadias in male rat offspring by maternal exposure to di-n-butyl phthalate (DBP) during late pregnancy and further investigate its mechanisms.

Methods: We randomly divided 20 pregnant rats into a DBP exposure and a control group, the former treated intragastrically with DBP while the latter with soybean oil at 750 mg per kilogram of the body weight per day from gestation days (GD) 14 to 18. On postnatal day (PND) 1, we recorded the incidence rate of hypospadias and observed the histopathological changes in the genital tubercle of the hypospadiac rats.

In situ observation of fracture behavior of canine cortical bone under bending.

Cortical bone provides many important body functions and maintains the rigidness and elasticity of bone. A common failure mode for bone structure is fracture under a bending force. In the current study, the fracture behavior of canine cortical bone under three-point bending was observed in situ using an atomic force microscope (AFM), a scanning electron microscope (SEM), and an optical microscope to examine the fracture process in detail.

[Biosynthetic schwertmannite as catalyst in Fenton-like reactions for degradation of methyl orange].

Biosynthesized schwertmannite was used as catalyst in photo-Fenton-like reaction to facilitate the degradation of methyl orange (MO). Schwertmannite was synthesized through the oxidation of FeSO4 by Acidithiobacillus ferrooxidans LX5 cell suspension at an initial pH 2.5 and 28 degress C for 3 days and characterized using X-ray diffraction spectroscopy and scanning electron microscope.

Complete mitochondrial genome sequence and mutations of the laryngeal cancer model inbred nude rat strain.

In the present work, we undertook the complete mitochondrial genome sequencing of an important laryngeal cancer model inbred rat strain for the first time. The total length of the mitogenome was 16,308 bp. It harbored 13 protein-coding genes, two ribosomal RNA genes, 22 transfer RNA genes, and one non-coding control region (D-loop region).

[Photochemical degradation of landfill leachate facilitated by combined schwertmannite and H2O2].

It is practically important that high concentrations of organic pollutants in landfill leachate were degraded by a rapid and efficient approach. The influence of operating conditions such as schwertmannite dosage, V(H2O2)/m (schwertmannite) ratio on the degradation efficiency of color, TOC and COD contents of landfill leachate, was investigated by using the schwertmannite/H2O2/UV process. It was demonstrated that the color, TOC and COD removal efficiencies increased significantly with the increase in schwertmannite dosage, and then were approximately stable.

Multiscale hierarchical assembly strategy and mechanical prowess in conch shells (Busycon carica).

Seashells are natural body armors with superior mechanical strength and ultra-high toughness compared with their major constituent counterparts. What building blocks and architecture render seashells such mechanical prowess? In this study, micro/nanoscale structural and mechanical characterization of conch shells (Busycon carica) has been carried out. Here we show direct evidence that the previously claimed single-crystal third-order lamellae--the basic building blocks in conch shells are essentially assembled with aragonite nanoparticles of the size ranging from 20 to 45 nm.

Characterization of hepatitis B virus genotypes/subgenotypes in 1,301 patients with chronic hepatitis B in North China.

Background: There is still a paucity of data on hepatitis B virus (HBV) subgenotype prevalence in North China based on sequencing of large-size samples. In addition, whether HBV genotypes impact drug-resistance-associated and HBV e antigen (HBeAg)-loss-associated mutations in patients with chronic hepatitis B (CHB) is still under investigation. This study aimed to disclose clinical prevalence of HBV genotypes/subgenotypes in North China and the clinical implications of HBV genotype classification in respect to HBeAg loss and drug-resistant occurrence.

Hydrogen passivation induced dispersion of multi-walled carbon nanotubes.

A method combining hydrogen passivation and ultrasonication was developed for the first time to disperse multi-walled carbon nanotubes (MWCNTs) in ethanol solution and epoxy resin. Excellent dispersion of MWCNTs was achieved in both media. Three-point bending tests of the MWCNT/epoxy nanocomposites revealed a remarkable increase in elastic modulus with increasing MWCNT content.

Electrical self-healing of mechanically damaged zinc oxide nanobelts.

We report the observation of remarkable electrical self-healing in mechanically damaged ZnO nanobelts. Nanoindentation into intrinsically defect-free ZnO nanobelts induces deformation and crack damage, causing a dramatic electrical signal decrease. Two self-healing regimes in the nanoindented ZnO nanobelts are revealed.

Catalyst-free synthesis and structural and mechanical characterization of single crystalline Ca2B2O5.H2O nanobelts and stacking faulted Ca2B2O5 nanogrooves.

Single crystalline Ca(2)B(2)O(5).H(2)O (CBOH) nanobelts were synthesized for the first time using a facile catalyst-free hydrothermal method at low temperature. After being annealed at 400 degrees C for 10 h, the CBOH nanobelts transformed into curve-shaped Ca(2)B(2)O(5)(CBO) nanogrooves with ordered stacking fault arrays along the [110] direction.