Publications by authors named "Zhi Duo Hou"
Article Synopsis
- Axial spondyloarthritis (axSpA) is a chronic inflammatory condition that primarily affects the spine, and this study focused on the clinical characteristics of non-radiographic axSpA (nr-axSpA) patients in China, comparing adult-onset and juvenile-onset cases.
- A total of 776 nr-axSpA patients were analyzed, revealing that the median age of onset was 22 years, with a higher ratio of men in the juvenile-onset group and notable differences in disease duration and family history of spondyloarthritis.
- The study found that juvenile-onset patients experienced more peripheral arthritis, while adult-onset patients had higher instances of inflammatory back pain, indicating differing patterns in symptoms based
Article Synopsis
- A study aimed to explore how specific genetic variations (single nucleotide polymorphisms, or SNPs) in the TNFα gene affect the effectiveness of adalimumab (ADA) treatment for patients with ankylosing spondylitis (AS).
- Eighty patients receiving ADA were monitored over 24 weeks, evaluating the impact of six specific SNPs on treatment outcomes.
- Results indicated that patients with the +489 A allele had significantly better responses to ADA, suggesting that testing for this SNP could help predict which patients will benefit most from the therapy.
Objective: To evaluate the clinical characteristics of juvenile-onset non-radiographic axial spondyloarthritis (nr-axSpA) and to investigate risk factors associated with progression to juvenile-onset ankylosing spondylitis (JoAS).
Methods: A nested case-control study was conducted using the retrospectively collected data of 106 patients with juvenile-onset nr-axSpA (age at disease onset, <16 years) in the Clinical characteristic and Outcome in Chinese Axial Spondyloarthritis study cohort. Baseline demographic and clinical characteristics and prognosis were reviewed.
Background: The pathogenesis of sacroiliitis is unclear; therefore, we aimed to systematically study the immunopathology of sacroiliitis in patients with axial spondyloarthritis (axSpA), and explore the relationship between pannus formation, inflammation, and the structural damage caused by sacroiliitis.
Methods: Fine needle aspiration biopsy of the sacroiliac joint (SIJ) was performed in 193 patients with axSpA. Clinical, laboratory, and imaging data were collected at baseline and during the follow up.
Background: Systemic lupus erythematosus (SLE) is associated with cognitive deficit but the exact neural mechanisms remain unclear.
Purpose: To explore sequential brain activities using functional magnetic resonance imaging (fMRI) during the performance of a decision-making task, and to determine whether serum or clinical markers can reflect the involvement of the brain in SLE.
Subjects: Sixteen female SLE patients without overt clinical neuropsychiatric symptoms and 16 healthy controls were included.
This study aimed to clarify changes in the prevalence of rheumatic diseases in Shantou, China, in the past 3 decades and validate whether stair-climbing is a risk factor for knee pain and knee osteoarthritis (KOA). The World Health Organization-International League Against Rheumatism Community Oriented Program for Control of Rheumatic Diseases (COPCORD) protocol was implemented. In all, 2337 adults living in buildings without elevators and 1719 adults living in buildings with elevators were surveyed.
View Article and Find Full Text PDFObjectives: This study aimed to investigate the risk of adverse events and effects on bone mineral density (BMD), blood lipid and glucose levels and body mass index (BMI) of low-dose glucocorticoid (GC) treatment in ankylosing spondylitis.
Design: We performed a retrospective, observational cohort study. Adverse effects were compared between GC users and non-GC users, and we analysed differences in the duration of GC exposure (no GC exposure, <6 months, 6 months to 2 years and >2 years).
Article Synopsis
- The study aimed to determine how common osteoporosis (OP) is in patients with ankylosing spondylitis (AS) and identify related risk factors.
- Researchers analyzed data from 504 AS patients and compared them to 106 healthy controls, finding that AS patients had a significantly higher prevalence of both OP and osteopenia.
- Key risk factors for bone loss included juvenile onset, morning stiffness, male gender, older age, hip involvement, and lack of treatment, while low-dose glucocorticoid treatment did not increase OP risk.
Background: Polymorphisms of Arylamine N-acetyltransferase (NAT) that contribute to diverse susceptibilities of some autoimmune diseases are also linked to the metabolism of several drugs including sulfasalazine (SSZ). The aim of this study was to investigate the distribution of NAT polymorphisms in Han Chinese patients with ankylosing spondylitis (AS) and their correlation to sulfasalazine-induced adverse drug reactions (ADRs).
Methods: Arylamine N-acetyltransferase 1 (NAT1) and arylamine N-acetyltransferase 2 (NAT2) genotypes were determined in 266 AS patients who received SSZ treatment and 280 healthy controls.
To study the potential correlations between variances of TNFalpha gene and onset of ankylosing spondylitis in Chinese population, We scanned and analyzed the promoters of TNFalpha genes in 75 AS patients from south of China and found -850 T mutation allele frequency rather high (39.3%).By case-control study, the distribution of TT genotype is significantly higher in AS patients than that in normal subjects (10.
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