Publications by authors named "Zhi'en Liu"
Free Radic Biol Med
November 2024
Article Synopsis
- Cerebral ischemia-reperfusion injury (CI/RI) leads to neuronal damage, with mitophagy's role in this process still debated.
- The study hypothesized that TRIM25 enhances mitophagy through the ubiquitination of ATAD3A, aggravating CI/RI.
- Experiments demonstrated that TRIM25 reduces ATAD3A, promoting mitophagy via the PINK1/Parkin pathway, and highlighting a complex interaction between these proteins during ischemic injury.
