Publications by authors named "Zhezi Xianyu"
Clostridium perfringens (CP) is the etiologic agent of necrotic enteritis (NE) in broiler chickens that is responsible for massive economic losses in the poultry industry in response to voluntary reduction and withdrawal of antibiotic growth promoters. Large variations exist in the CP isolates in inducing intestinal NE lesions. However, limited information is available on CP isolate genetics in inducing NE with other predisposing factors.
View Article and Find Full Text PDF(CP) type A and newly created type G strains are the key etiological factors in the induction of necrotic enteritis (NE), an important enteric disease that is responsible for the annual loss of $6 billion in the worldwide poultry industry. Several CP toxin genes were found to be critical in NE pathogenesis in chickens, but limited information is available on the CP lethal toxin gene. In this study, 19 CP strains isolated from NE-affected chicken farms were characterized microbiologically and molecularly and evaluated for their pathogenicity in commercial broiler chickens.
View Article and Find Full Text PDFArticle Synopsis
- Eimeria protozoans cause coccidiosis in chickens, which is a major economic concern due to limited knowledge of host-parasite interactions that hampers control measures.
- RNA sequencing was used to analyze mRNA from cecal samples of infected and uninfected chickens, revealing significant changes in gene expression, including many related to immune responses.
- The study identified numerous upregulated and downregulated genes and highlighted potential pathways affected by Eimeria maxima infection, providing important insights into the molecular mechanisms of this host-parasite relationship.