Chromosome-level genome assembly and annotation of the crested gecko, , a lizard incapable of tail regeneration.

Unlabelled: The vast majority of gecko species are capable of tail regeneration, but singular geckos of , , and genera are unable to regrow lost tails. Of these non-regenerative geckos, the crested gecko () is distinguished by ready availability, ease of care, high productivity, and hybridization potential. These features make particularly suited as a model for studying the genetic, molecular, and cellular mechanisms underlying loss of tail regeneration capabilities.

Single-cell analysis of lizard blastema fibroblasts reveals phagocyte-dependent activation of Hedgehog-responsive chondrogenesis.

Lizards cannot naturally regenerate limbs but are the closest known relatives of mammals capable of epimorphic tail regrowth. However, the mechanisms regulating lizard blastema formation and chondrogenesis remain unclear. Here, single-cell RNA sequencing analysis of regenerating lizard tails identifies fibroblast and phagocyte populations linked to cartilage formation.