Publications by authors named "Zheyi Lin"
Introduction: Cell fate determination and transition are of paramount importance in biology and medicine. Naive pluripotency could be achieved by reprogramming differentiated cells. However, the mechanism is less clear.
View Article and Find Full Text PDFSALL2 regulates neural differentiation of mouse embryonic stem cells through Tuba1a.
Cell Death Dis
September 2024
Article Synopsis
- The study focuses on the SALL2 gene, part of the spalt gene family, and its critical role in mouse embryo development, particularly in the nervous system.
- * Researchers found that SALL2 is essential for neural differentiation, as Sall2 knockout embryonic stem cells showed impaired ability to become neural stem cells and create neural tube organoids.
- * Utilizing ChIP-seq, the study identified Tuba1a as a key target gene influenced by SALL2, highlighting its importance in understanding potential human nervous system disorders linked to SALL2 mutations.
A new paradigm for generating high-quality cardiac pacemaker cells from mouse pluripotent stem cells.
Signal Transduct Target Ther
September 2024
Cardiac biological pacing (BP) is one of the future directions for bradyarrhythmias intervention. Currently, cardiac pacemaker cells (PCs) used for cardiac BP are mainly derived from pluripotent stem cells (PSCs). However, the production of high-quality cardiac PCs from PSCs remains a challenge.
View Article and Find Full Text PDFBackground: Cardiovascular diseases (CVDs) have the highest mortality worldwide. Human pluripotent stem cells (hPSCs) and their cardiomyocyte derivatives (hPSC-CMs) offer a valuable resource for disease modeling, pharmacological screening, and regenerative therapy. While most CVDs are linked to significant over-production of reactive oxygen species (ROS), the effects of current antioxidants targeting excessive ROS are limited.
View Article and Find Full Text PDFArticle Synopsis
- Transcription factors HAND1 and HAND2 are crucial for heart development, and their abnormal expression can lead to serious heart defects, but their exact roles in early heart cell formation are not well understood.
- Researchers created human embryonic stem cell lines with knocked out HAND1 and HAND2 to study how these factors affect cardiomyocyte differentiation, employing techniques like flow cytometry and RNA sequencing to track changes.
- Results showed that knocking out both HAND1 and HAND2 delayed heart cell differentiation, affected the development of specific heart cell types, and altered the electrical characteristics of the resulting cardiomyocytes.
Anthracyclines including doxorubicin (DOX) are still the most widely used and efficacious antitumor drugs, although their cardiotoxicity is a significant cause of heart failure. Despite considerable efforts being made to minimize anthracycline-induced cardiac adverse effects, little progress has been achieved. In this study, we aimed to explore the role and underlying mechanism of SNX17 in DOX-induced cardiotoxicity.
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