Astaxanthin Alleviates Foam Cell Formation and Promotes Cholesterol Efflux in Ox-LDL-Induced RAW264.7 Cells via CircTPP2/miR-3073b-5p/ABCA1 Pathway.

Atherosclerosis (AS) is a common cardiovascular disease and remains the leading cause of death in the world. It is generally believed that the deposition of foam cells in the arterial wall is the main cause of AS. Moreover, promoting cholesterol efflux and enhancing the ability of reverse cholesterol transport (RCT) can effectively inhibit the formation of foam cells, thereby preventing the occurrence and development of AS.

Diagnostic value of circRNAs as effective biomarkers in human cardiovascular disease: an updated meta-analysis.

A growing body of literature has demonstrated that circular RNAs (circRNAs) are the potential biomarkers in human cardiovascular disease (CVD). Therefore, a meta-analysis based on current studies was accomplished to appraise the role of circRNAs in the diagnostic of CVD patients. Studies before October 30, 2021, were searched using PubMed, EMBASE, the Web of Science, and Cochrane Library.

Expression of the circular RNAs in astaxanthin promotes cholesterol efflux from THP-1 cells based on RNA-seq.

Background: It is reported that circular RNAs (circRNAs) play a key role in atherosclerosis (AS). Foam cell formation, which is the main feature of AS, can be significantly inhibited by cholesterol efflux.

Methods: We established a model of astaxanthin (AST) promoting cholesterol efflux from macrophages through oil red O staining, real-time quantitative PCR (qRT-PCR), and western blot and used RNA sequencing to detect the expression of circRNAs in AST-treated and untreated THP-1 cells.

The potential diagnostic value of extracellular vesicle miRNA for human non-small cell lung cancer: a systematic review and meta-analysis.

: This meta-analysis aimed to evaluate the diagnostic accuracy of extracellular vesicles (EV) miRNAs for non-small cell lung cancer (NSCLC).: All eligible studies were searched in an online database. Stata 15.

The prognostic significance of long non-coding RNAs in hepatocellular carcinoma: An updated meta-analysis.

Background: Recently, many studies have demonstrated that long non-coding RNAs (lncRNAs) are abnormally expressed in hepatocellular carcinoma (HCC) and may serve as a potential molecular biomarker to evaluate the prognosis of hepatocellular carcinoma. Therefore, we accomplished a meta-analysis built on current studies to assess the prognostic value of lncRNAs in hepatocellular carcinoma.

Methods: The PubMed database was carefully searched to collect all eligible studies until February 20, 2019.

You did not mean it: Perceived good intentions alleviate sense of unfairness.

Previous research has reported that feedback-related negativity (FRN) may represent the degree of perceived unfairness in the ultimatum game (UG). However, few studies have incorporated intention-related consideration in examining the neural correlates of fairness perception. To address this issue, the present study introduced an intentional UG paradigm to disentangle the effect of perceived intention from fairness concerns, using an event-related potential (ERP) analysis.