[Results of immunoprophylaxis of HIV-infected patients with 13-valent conjugated pneumococcal vaccine].

Aim: To assess changes in the composition of the microflora of the upper respiratory tract and indicators of cellular immunity 1 year after the administration of 13-valent conjugated pneumococcal vaccine (PCV13) in adult HIV-infected patients.

Materials And Methods: Were recruited 100 participants of both sexes (50% male and 50% female). All patients underwent microbiological and immunological (determination of the level of CD3+, CD3+CD4+, CD3+CD8+, CD19+, CD45RO+ peripheral blood lymphocytes) examinations before vaccine administration and after 12 months.

Microflora of sputum and autopsy material of patients with COVID-19.

The rapid spread of a new coronavirus infection in the country actualizes the conduct of bacteriological studies of clinical material obtained from the respiratory tract of patients with COVID-19. During the experiments, 230 sputum samples and 260 autopsy lung samples from patients with COVID-19 were analyzed. 946 high-risk strains were isolated and identified by MALDI-ToF mass spectrometry on a Microflex LT instrument (Bruker®).

A randomized trial assessing the efficacy, immunogenicity, and safety of vaccination with live attenuated varicella zoster virus-containing vaccines: ten-year follow-up in Russian children.

In Russia, a universal varicella vaccination (UVV) program has not been implemented, and varicella vaccination coverage is low. We assessed the efficacy, antibody persistence, and safety of one- and two-dose varicella vaccination schedules in Russian children with a ten-year follow-up period, as part of an international phase IIIB, observer-blind, randomized, controlled trial (NCT00226499). Children aged 12-22 months were randomized (3:3:1) to receive two doses of tetravalent measles-mumps-rubella-varicella vaccine (V2 group), one dose trivalent measles-mumps-rubella (MMR) vaccine and one dose of varicella vaccine (V1 group), or two doses of MMR vaccine (V0 [control] group), 42 days apart.

General characteristics, features of cultivation and antibiotic resistance representatives of mycobacterium fortuitum group representatives (review of literature).

Recently, more and more scientific works have been devoted to non-tuberculous mycobacteria, both by domestic and foreign researchers. One of the main reasons for this is the increase in patients with immunosuppression of various origins, improvement of the quality of laboratory and instrumental diagnostics of mycobacteriosis. This article focuses on the representatives of the M.

[Experience with 13-valent conjugated pneumococcal vaccine in HIV-infected patients].

Aim: Evaluate the effect of PCV13 vaccination on the composition of the microflora of the upper respiratory tract and the immune system in HIV-infected patients.

Materials And Methods: 100 patients with HIV-infection were included in the study. The patients underwent immunological examination and the collection of biomaterial from the posterior pharyngeal wall for microbiological examination.

Primary Immunodeficiencies in Russia: Data From the National Registry.

Primary immunodeficiencies (PID) are a group of rare genetic disorders with a multitude of clinical symptoms. Characterization of epidemiological and clinical data via national registries has proven to be a valuable tool of studying these diseases. The Russian PID registry was set up in 2017, by the National Association of Experts in PID (NAEPID).

[Structure of microorganisms isolated from bronhoalveolar lavage from patients in the department of reanimation and intensive therapy.].

The aim of the work was to determine and compare the structure of microorganisms isolated from bronchoalveolar lavage from patients in the ICU of Clinics in 2016 and 2019. This work presents the results of a bacteriological examination of 229 samples from 139 patients for 2016 and 387 samples from 218 patients for 2019. The predominant microorganism in 2016 was Acinetobacter baumanii - 75 (26.

[Mycobacterium abscessus complex representatives in patients with bronchopulmonary pathology: prevalence, peculiarities of cultivation and identification.].

More and more publications appear in the modern literature on the increase in the prevalence of non-tuberculous mycobacteria (NTMs), in particular, representatives of M. chelonae / Mycobacterium abscessus complex (MABSc). The paper presents data on the current classification of M.

[The structure of conditionally pathogenic microflora, isolated from the urogenital tract of women with pathological course of pregnancy.].

The structure of the microflora of the urogenital tract of a woman is variable and diverse, changing its qualitative and quantitative composition can affect various physiological processes in the body of a woman, including the course of pregnancy. In this study, the results of cultures of 1415 samples of urine and cervical canal discharge of pregnant women were analyzed. Species identification was carried out by MALDI-ToF mass spectrometry using Microflex LT (Bruker) mass spectrometer.

Clinical releveance of hemorrhagic component of endobronchial inflammation in severe chronic obstructive pulmonary disease exacerbation.

Aim: The study aimed at investigating the relationship between severe exacerbations of chronic obstructive pulmonary disease and hemorrhagic component of endobronchial inflammation.

Materials And Methods: Clinico-endoscopic characteristics of 118 patients presenting with severe infectious exacerbation of chronic obstructive pulmonary disease, bloody expectorations and endoscopically confirmed hemorrhagic component of endobronchial inflammation have been analyzed. All patients underwent a series (5-6) of bronchoscopic examinations accompanied by collection of bronchoalveolar lavage specimens to reveal the presence of acid-resistant mycobacteria and to determine the bacterial flora.

[The laboratory diagnostic in patients with mucoviscidosis: A review.].

The mycobacterioses as a group of diseases conditioned by non-tuberculosis mycobacteria, acquire even greater significance for patients from various risk groups. The patients with cystic fibrosis along with patients with other genetic diseases, consist risk group of infection with non-tuberculosis mycobacteria. The diagnostic of mycobacterioses in patients with cystic fibrosis has a number of peculiarities both at the stage of processing clinical material and the stage of identification of separated microorganisms.

[Analysis of the effectiveness and long-term results of formation of adaptive immunity in the use of various medications and vaccination schemes against pneumococcal infection in patients with chronic obstructive pulmonary disease].

Aim: To assess the long-term clinical results of vaccination with pneumococcal polysaccharide and conjugated polysaccharide vaccines in the separate and sequential use, by determining the optimal vaccination schedule in adult patients with chronic obstructive pulmonary disease (COPD) and to investigate adaptive immunity levels.

Subjects And Methods: The clinical effects of vaccination were evaluated in patients with COPD within 1 and 4 years after immunization against pneumococcal infection using various schemes, as well as the time course of changes in adaptive immunity indicators was examined.

Results: Four years after vaccination, the 13-valent pneumococcal conjugate vaccine (PCV13)/23-valent pneumococcal polysaccharide vaccine (PPV23) group showed a decline in the number of patients with COPD exacerbations by 50% (p<0.

[Anogenital warts: a new way of solving the common problem of urology (results of long-term follow-up)].

Aim: To evaluate the effectiveness of combined use of the imiquimod 5% cream and vaccination against human papillomavirus (HPV) using a quadrivalent recombinant vaccine to achieve long-term clinical remission of chronic HPV infection manifested by anogenital warts.

Material And Methods: The study comprised 36 patients, including 22 men, aged 26.4+/-4.

[Choice of optimal vaccination tactics against pneumococcal infection from immunological and clinical standpoints in patients with chronic obstructive pulmonary disease].

Aim: To provide a rationale for choosing the optimal tactics of vaccination against pneumococcal infection in patients with chronic obstructive pulmonary disease (COPD) in the context of evidence-based medicine and on the basis of immunological and clinical data.

Subjects And Methods: Patients with COPD were examined during a year after vaccination with a 13-valent pneumococcal conjugate (Prevenar-13, PCV13) and a 23-valent pneumococcal polysaccharide (Pnemo-23, PPV23) vaccines. The following vaccination schemes were used: PCV13 monovaccination, PPV23 monovaccination, sequential vaccination with PPV23/PCV13, and sequential vaccination with PCV13/PPV23.

[New ideas on the therapeutic effect of a combination of vaccines against pneumococcal, Haemophilus influenzae type b infection, and influenza in patients with chronic obstructive pulmonary disease].

Aim: To estimate the indicators of the therapeutic effect of combination vaccination against pneumococcal, Haemophilus influenzae type b infection, and influenza in patients with chronic obstructive pulmonary disease (COPD).

Subjects And Methods: Clinical, bacteriological, and immunological studies, by determining the quality of life (QL), were conducted in COPD patients during a year after combination vaccination against pneumococcal, Haemophilus influenza type b infection, and influenza.

Results: One year after the vaccination, there were reductions in the number of COPD exacerbations by 3.

[Effect of complex vaccination against pneumococcal, Haemophilus type b infections and influenza in patients with chronic obstructive pulmonary disease].

Aim: Determination of the effect of complex vaccination with Pneumo-23, Hiberix, Grippol plus on sputum bacterial content 6 months after the vaccination of patients with chronic obstructive pulmonary disease (COPD) compared with unvaccinated patients.

Materials And Methods: Bacteriological analysis of sputum obtained for 6 months from 80 patients with COPD was carried out. The first group of 31 patients with COPD was immunized simultaneously with Pneumo-23, Hiberix, Grippol plus (mean age--59.

[Effect of phytosubstances with antioxidant activity on persistence properties of microorganisms].

The in vitro effect of phytosubstances containing flavonoids and phenylpropanoids on the antilysozyme activity of varioous groups of microorganisms, such as staphylococci, bacilli, enterobacteria and nonfermenting bacteria was studied. The second fraction of the pink carbonic acid extract showed high antioxidant activity and most efficiently inhibited the ability of various microorganisms to inactivate the host lysozyme. The selected phytosubstance could be useful in clinical practice as an additional antimicrobial agent in etiotropic therapy or prophylaxis of some infections.

[Monitoring and treatment of severe bronchial ashma in adults: results of national multicenter trial NABAT].

Aim: To study quality of monitoring, features of a course and therapy of severe bronchial asthma (BA) in Russia.

Materials And Methods: The trial recruited 378 patients with severe bronchial asthma (SBA) in 7 cities of Russia. Each center participating in the study filled in individual case sheets recording demographic, clinical, monitoring, pharmacotherapeutic data.

[Immunological changes in dust-induced lung diseases].

One hundred and forty five patients with different forms of dust-induced lung disease and 57 controls having no contacts with industrial aerosols were examined. It was ascertained that clinical and functional evidence cannot predict the course of the disease and the development of infectious complications (silicotuberculosis, mechanic bronchitis). Impaired humoral immunity and nonspecific resistance in dust-induced lung disease depend on the type of disease and predispose to infectious complications.

Spontaneous luminol-dependent chemiluminescence of thrombocytes increases in hemorrhagic fever with renal syndrome.

Spontaneous luminol-dependent chemiluminescence (CL) of thrombocytes was studied in 12 patients with hemorrhagic fever with renal syndrome (HFRS) caused by Puumala virus. CL in the acute phase of HFRS (median, 61 mV/10 sec; range, 22-91) was higher than that of healthy controls (median, 22 mV/10 sec; range, 18-29; P < 0.01) and patients with acute hepatitis B infection accompanied by thrombocytopenia (median, 33 mV/10 sec; range, 13-45; P < 0.

On the compact form of linear duplex DNA: globular states of the uniform elastic (persistent) macromolecule.

A theory of collapse of DNA considered as unifilar homopolymer is suggested. The collapse is interpreted as the coil-globule transition. Three reasons of the collapse such as the confinement in a microcavity, the influence of poor low-molecular-weight solvent and the influence of polymeric solvent were studied.

On the toroidal condensed state of closed circular DNA.

The influence of double helix torsional elasticity on the compaction and structure of circular DNA compact form is studied theoretically in the case when the compact (globular) form has torus shape. For closed circular DNA the topological invariant, the linking number, yields a strict connection between conformation of the double helix considered as unifilar homopolymer and elastic energy of torsional twisting. The contribution of torsional elasticity to the free energy of the toruslike globule is calculated.

[The state of a toroid-like DNA globule: the persistent macromolecule in a low-molecular solvent].

Dimensions of a toroidal globule appearing at the compactization of DNA macro-molecule in a poor low-molecular solvent are estimated. Diagram of DNA molecule state was analysed in variables: contour length-concentration of the precipitating agent. Possible existence of the tricritical point in the joint of the regions of coil, isotropic globular and liquid crystalline globular states was suggested.