Author Correction: Spectrally filtered passive Si photodiode array for on-chip fluorescence imaging of intracellular calcium dynamics.

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Single-Cell Optogenetic Control of Calcium Signaling with a High-Density Micro-LED Array.

Precise optogenetic control, ideally down to single cells in dense cell populations, is essential in understanding the heterogeneity of cell networks. Devices with such capability, if built in a chip scale, will advance optogenetic studies at cellular levels in a variety of experimental settings. Here we demonstrate optogenetic control of intracellular Ca dynamics at the single cell level using a 16-μm pitched micro-light emitting diode (LED) array that features high brightness, small spot size, fast response, and low voltage operation.

Spectrally filtered passive Si photodiode array for on-chip fluorescence imaging of intracellular calcium dynamics.

On-chip fluorescence imaging devices are recognized for their miniaturized and implantable nature that can benefit the study of intracellular dynamics at a variety of settings. However, it is challenging to integrate a spectral filter onto such devices (to block the excitation light) that has similar performance to the state-of-the-art emission filters used in fluorescence microscopes. In this work, we report a 100%-yield, spectrally filtered passive Si photodiode array designed for on-chip fluorescence imaging of intracellular Ca dynamics.