Publications by authors named "Zheran Chen"
Article Synopsis
- Immunotherapy for esophageal squamous cell carcinoma (ESCC) shows varying effectiveness, and recent research highlights the role of circular RNAs (circRNAs) in the tumor microenvironment.
- A comprehensive network of immune-related circRNA, microRNA, and mRNA was constructed, comprising 16 circRNAs, 13 microRNAs, and 1,560 mRNAs, revealing the competing endogenous RNA (ceRNA) dynamics in ESCC.
- Key findings included the identification of cancer-associated fibroblast (CAF) modules linked to immune scores, with specific collagen family genes showing elevated expression and potential as targets for ESCC treatment, contributing to more personalized clinical approaches.
Background: Given the significant burden of upper digestive diseases, there has been a substantial increase in the utilization of esophagogastroduodenoscopy (EGD) in China from 2012 to 2019. The objective of this study is to investigate the development, practice, and factors influencing the widespread use of EGD during this period.
Methods: Two national censuses were conducted among all hospitals in mainland China that perform gastrointestinal endoscopy.