Publications by authors named "Zheqian Zhang"
Article Synopsis
- - Healing critical-sized calvarial bone defects is difficult, with immune responses being crucial for bone regeneration following grafting; recent research highlights the importance of dural cells in this process.
- - A study developed various 3D elastomers made of polycaprolactone (PCL) and poly(glycerol sebacate) (PGS), enhanced with polydopamine (PDA), to serve as implants for bone defects, showing how effective properties can influence healing.
- - Results indicated that these elastomers improved the activity of M2 macrophages and attracted dural cells, leading to successful bone repair through multiple ossification processes, revealing significant interactions between these cells as a target for future graft designs. *
Article Synopsis
- Researchers developed a 3D-printed sponge using cuttlefish bone elastomerics that enhances blood absorption and quickly returns to its shape, addressing challenges in treating noncompressible hemorrhage.
- The sponge, enriched with cuttlefish bone powder, improves blood component concentration and platelet activation, outperforming traditional gelatin sponges in promoting hemostatic efficiency in live tests.
- Additionally, the sponge encourages early-stage tissue healing and regeneration, indicating its potential use in medical applications and traditional Chinese medicine.
Article Synopsis
- Anesthetics, specifically isoflurane, negatively impact neurogenesis in young mice, which may lead to long-term cognitive deficits.
- The study investigated the effects of anesthetics on new cell generation from different regions in the brain (dentate gyrus) during postnatal development, revealing significant reductions in cell numbers from certain areas.
- Results showed that isoflurane exposure specifically impairs the proliferation and survival of younger cells, correlating with behavioral deficits in learning tasks.
Ochratoxin A (OTA) contamination is a worldwide problem in pig industry. The objectives of the present study were to investigate the toxicity of natural OTA in weaned piglets and to further explore the underlying mechanisms. Totally, 36 crossbred ([Landrace × Yorkshire] × Duroc) piglets were randomly divided into 3 groups (three replicates per group, 4 piglets per replicate), and fed a basal diet (Con group) and basal diets added with 0.
View Article and Find Full Text PDFPorcine circovirus type 2 (PCV2) is the primary causative agent of porcine circovirus-associated disease (PCVAD). Astragalus polysaccharide (APS), as one kind of biological macromolecule extracted from Astragalus, has antiviral activities. This study was undertaken to explore the effect of APS on PCV2 replication in vitro and the underlying mechanisms.
View Article and Find Full Text PDFOchratoxin A promotes porcine circovirus type 2 replication in vitro and in vivo.
Free Radic Biol Med
March 2015
Ochratoxin A (OTA), a worldwide mycotoxin found in food and feeds, is a potent nephrotoxin in animals and humans. Porcine circovirus-associated disease (PCVAD), including porcine dermatitis and nephropathy syndrome, is a worldwide swine disease. To date, little is known concerning the relationship between OTA and porcine circovirus type 2 (PCV2), the primary causative agent of PCVAD.
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