Contactin-2 (CNTN2), an immunoglobulin cell adhesion molecule (IgCAM) expressed on the neural cell surface, regulates the formation of myelin sheaths, facilitates communication between neurons and axoglial cells, and coordinates the migration of neural cells. However, the assembly of full-length CNTN2 is still not fully elucidated. Here, we found that the full-length human CNTN2 forms a concentration-dependent homodimer.
View Article and Find Full Text PDFFunct Integr Genomics
December 2024
Objective: To investigate the mechanism of Bushen Huoxue decoction (, BSHXD) to treat endometriosis-induced infertility.
Medhods: The main compounds of BSHXD were determined by high performance liquid chromatography-mass spectrometry (HPLC-MS/MS). The effect of BSHXD on Homeobox A10 (HOXA10) and alpha(v)beta(3) (αvβ3) integrin expression of Ishikawa cells, mouse model, and endometriosis-associated infertility women was evaluated by using Western blot analysis, immunohistochemistry and Real-Time quantitative polymerase chain reaction (RT-qPCR).
Cold stress is one of the main abiotic stresses that affect the development and growth of kiwifruit (). Herein, we analyzed the transcriptomic data of dormant shoots in response to low-temperature treatment, identified 52 MYB genes, and constructed a phylogenetic tree based on the encoded protein sequences. Then, the effect of one gene on cold tolerance was analyzed.
View Article and Find Full Text PDFMycoplasma hyopneumoniae (M. hyopneumoniae) is the causative agent of swine enzootic pneumonia, resulting in substantial economic losses in global pig farming. Although vaccination is the primary strategy for controlling M.
View Article and Find Full Text PDFObjective: To investigate the epidemiological characteristics of hepatocellular carcinoma in Xiamen and offer recommendations for its control and prevention.
Methods: Data obtained from liver cancer screening in 2016-2018 and 2019-2020 in patients with hepatocellular carcinoma in Xiamen were collected using Xiamen Healthcare Big Data Platform. Epidemiological characteristics were analyzed descriptively by different years.
In traditional multienzyme random co-immobilization, it is difficult to precisely locate and regulate the relative positions between two enzyme molecules, resulting in low cascade efficiency between the two enzymes and limiting the application of multienzyme cascade catalysis technology. This study prepared PVAC@Y-dsDNA@GOD/HRP magnetic co-immobilized multienzyme by constructing a three-pronged DNA scaffold for co-coupling glucose oxidase (GOD) and horseradish peroxidase (HRP), which achieved directional co-immobilization of dual enzymes and precise regulation of inter-enzyme distance. Compared with traditional random co-immobilization of multienzyme, PVAC@Y-dsDNA@GOD/HRP could shorten the distance between GOD and HRP to the nanoscale and form substrate channeling, which greatly improved the cascade activity between the two enzymes.
View Article and Find Full Text PDFAfrican Swine Fever (ASF) is an acute, highly contagious, and lethal disease caused by the African Swine Fever Virus (ASFV), posing a severe threat to the global pig farming industry. Although live vaccines are currently available, preventing and controlling ASF remains a considerable challenge. Several factors have impeded vaccine development, including the complexity of ASFV particles and the suppressive effects of its gene-encoded proteins on the host's immune system.
View Article and Find Full Text PDFA study combining multiscale numerical simulation and low-velocity impact (LVI) experiments was performed to explore the comprehensive effects on the impact-resistance of EMAA filaments incorporated as thermoplastic healing agents into a plain woven composite. A multiscale micro-meso-macro modeling framework was established, sequentially propagating mechanical performance parameters among micro-meso-macro models. The equivalent mechanical parameters of the carbon fiber bundles were predicted based on the microscopic model.
View Article and Find Full Text PDFBackground: The leftover material from the heat-pressing of IPS e.max Press ceramic is often discarded, despite some laboratories exploring its potential for reuse. However, there is a lack of data on the performance of IPS e.
View Article and Find Full Text PDFBackground: Talaromyces marneffei (T. marneffei) is an opportunistic pathogen that causes endemic mycoses, which could lead to multiple organ damage. Talaromycosis is frequently disregarded as an early cautionary sign of immune system disorders in non-HIV-infected children.
View Article and Find Full Text PDFThe growing demands for X-ray imaging applications impose diverse and stringent requirements on advanced X-ray detectors. Among these, flexibility stands out as the most expected characteristic for next-generation X-ray detectors. Flexible X-ray detectors can spatially conform to nonflat surfaces, substantially improving the imaging resolution, reducing the X-ray exposure dosage, and enabling extended application opportunities that are hardly achievable by conventional rigid flat-panel detectors.
View Article and Find Full Text PDFObjective: To explore the mechanism underlying the therapeutic effect of Bufei Yishen Formula III combined with exercise rehabilitation (ECC-BYF III + ER) on chronic obstructive pulmonary disease (COPD) and further identify hub genes.
Materials And Methods: Gene Set Enrichment Analysis was used to identify the COPD-associated pathways and reversal pathways after ECC-BYF III + ER treatment. Protein-protein interaction network analysis and cytoHubba were used to identify the hub genes.
Complement Ther Med
October 2024
Objective: To summarize the current available evidence and to outline recommendations for the future research of acupuncture for patients after percutaneous coronary intervention (PCI).
Design: Seven electronic databases were searched: China National Knowledge Infrastructure (CNKI), Wan Fang Database, Chongqing VIP Chinese Science and Technology Periodical Database (VIP), Chinese Biomedical Literature Database (CBM), Cochrane Library, PubMed, and EMBASE. All studies on acupuncture for patients after PCI were included.
Precise monitoring of biomolecular radiation damage is crucial for understanding X-ray-induced cell injury and improving the accuracy of clinical radiotherapy. We present the design and performance of lanthanide-DNA-origami nanodosimeters for directly visualizing radiation damage at the single-particle level. Lanthanide ions (Tb or Eu) coordinated with DNA origami nanosensors enhance the sensitivity of X-ray irradiation.
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