Publications by authors named "Zhenzhen Lou"
Background: Contactin-1 (CNTN1) antibody-positive nodopathy is rare and exhibits distinct clinical symptoms such as tremors and ataxia. However, the mechanisms of these symptoms and the characteristics of the cerebral spinal fluid (CSF) remain unknown.
Case Presentation: Here, we report a case of recurrent CNTN1 antibody-positive nodopathy.
Article Synopsis
- * A retrospective analysis of MS patients over 11 years found that 34.1% experienced neuropathic pain, with longer spinal lesions significantly increasing pain risk.
- * Key risk factors identified include the presence of cervical and thoracic spinal lesions, particularly upper thoracic lesions, while basal ganglia lesions were found to have a negative correlation with neuropathic pain.
Article Synopsis
- This study explores the link between gut microbiota and high on-treatment platelet reactivity (HTPR) in acute ischemic stroke (AIS) patients by comparing them to non-HTPR patients and healthy controls.
- A total of 48 AIS patients participated, and researchers used advanced sequencing techniques to analyze their gut bacteria, finding that HTPR patients had lower microbial diversity and specific bacterial imbalances.
- The results suggest that certain combinations of gut bacteria can effectively predict HTPR occurrence in AIS patients, highlighting potential new biomarkers for this condition.
Article Synopsis
- A 42-year-old woman with refractory neuromyelitis optica spectrum disorder (NMOSD) had poor responses and serious side effects from multiple immunosuppressants.
- After several relapses and unsuccessful treatments, she was given Ofatumumab, which stabilized her condition.
- The case suggests that Ofatumumab could be a safe and effective option for NMOSD patients who do not respond to other therapies.
Article Synopsis
- Neuropathic pain commonly occurs in patients with neuromyelitis optica spectrum disorder (NMOSD) and negatively impacts their quality of life, with unclear risk factors for its development.
- The study aimed to identify these risk factors in a cohort of NMOSD patients by analyzing clinical data from individuals diagnosed between January 2011 and October 2021.
- Out of 119 screened patients, 86 met the criteria, revealing a 43% prevalence of neuropathic pain, with age at onset and specific attack types being significant associated factors.
Immune checkpoint inhibitors have been critical in the treatment of advanced malignancies in recent years. Encephalitis caused by atezolizumab is an uncommon immune-related adverse event. The case of a 65-year-old female diagnosed with encephalitis closely associated with atezolizumab medication for metastatic advanced breast cancer is presented in the current study.
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- * Researchers found that patients with high TG levels (≥1.7mmol/L) had a significantly higher rate of high on-treatment platelet reactivity (HTPR) compared to those with lower TG levels (36.2% vs 9.2%).
- * The findings suggest that high TG is an independent risk factor for HTPR in IS patients, indicating the need for regular platelet monitoring to optimize anti-platelet therapy and improve treatment outcomes.