Octominin: An antimicrobial peptide with antibacterial and anti-inflammatory activity against carbapenem-resistant Escherichia coli both in vitro and in vivo.

Objectives: The emergence of carbapenem-resistant Escherichia coli (CREC) is a global concern as its prevalence restricts treatment options and poses a considerable threat to public health. In this study, in vitro and in vivo activity of the antimicrobial peptide Octominin against CREC was investigated to reveal possible mechanisms of action. Furthermore, its safety and factors influencing its antibacterial effect were assessed.

[The significance of evaluation of sleep respiration in infants with Pierre Robin sequence].

This study aimed to evaluate the sleep disorders of infants with Pierre Robin sequence by PSG, and to understand the sleep breathing characteristics of them. Seventeen patients with Pierre Robin sequence underwent polysomnography lasting over 7 hours. Sleep apnea and oxygen index was recorded and analyzed.

The characteristics and clinical significance of REM<10% in children with sleep-disordered breathing.

Objective: Fractional time in REM sleep <20% ('little REM sleep') is indicative of more severe sleep-disordered breathing (SDB) in adults. We examined if other REM% is predictive of more severe SDB in children.

Methods: In this retrospective study of 616 pediatric SDB patients, age, sex ratio, BMI, sleep efficiency, awakening frequency, sleep latency, apnea-hypopnea index (AHI), obstructive apnea index (OAI), and lowest oxygen pulse saturation (LSpO) were compared among groups stratified according to REM%: REM≥20%, REM<20%, 15% ≤ REM<20%, 10% ≤ REM<15%, and REM<10%.

miR-1, regulated by LMP1, suppresses tumour growth and metastasis by targeting K-ras in nasopharyngeal carcinoma.

There is evidence to show that downregulation of miR-1 expression is closely related to cancer progression, including in nasopharyngeal carcinoma (NPC). However, the molecular mechanisms underlying miR-1 downregulation in NPC remain largely unknown, especially its association with Epstein-Barr virus (EBV). In this study we found that restoration of miR-1 dramatically inhibited cell invasion in vitro, together with tumour growth and metastasis in vivo.

Small magnet aspiration as a pediatric emergency: a case report.

Tracheobronchial airway foreign body aspiration (FBA) in children is a common and serious pediatric medical emergency. With the increasing use of small magnets in home offices, in toys and the kitchen, inhalation of small magnets has become an increasing risk to children. We present a case of a 9-year-old boy who presented with cough and dyspnea three days following inhalation of an 3 cm-sized oval magnet.

[Study on the relationship between tone burst ABR and CE-Chirp ASSR in infants with profound sensorineural hearing loss].

Objective: To analyse the correlation between tone burst auditory brainstem response (tone burst auditory brainstem response, tb-ABR) and CE-Chirp voice evoked auditory steady-state response (auditory steady-state response, CE-Chirp ASSR) in infants with profound sensorineural hearing loss.

Methods: A total of 45 infants with profound sensorineural hearing loss underwent threshold tone burst ABR and CE-Chirp ASSR of the frequency response test, response thresholds were recorded in 0.5, 1.

Measurement of nasal and fractional exhaled nitric oxide in children with upper airway inflammatory disease: Preliminary results.

Objectives: To assess the clinical significance of nasal nitric oxide (nNO) and fractional exhaled nitric oxide (FeNO) concentrations in children with upper airway inflammatory disease.

Methods: Fifteen healthy children, 30 with allergic rhinitis (AR), 10 with non-allergic rhinitis (NAR), and 30 with sleep disordered breathing (SDB) were enrolled. The FeNO and nNO concentrations were measured non-invasively using a NIOX MINO system.

Rheumatoid factor interference of α-fetoprotein evaluations in human serum by ELISA.

Background: Serum a-fetoprotein (AFP) is one of the most common diagnostic markers for hepatocellular cancer (HCC) in the laboratory. As other immunoassays, AFP determination is not free from interferences. Natural antibodies like rheumatoid factors (RFs) may induce falsely elevated results, leading to misdiagnosis and expensive unnecessary explorations.

[Analysis of the factors associated with non-adherence to therapy with home-based remote monitoring noninvasive positive pressure ventilation in children with obstructive sleep apnea-hypopnea syndrome and risk factors].

Objective: To discuss the factors associated with non-adherence to therapy with home-based remote monitoring noninvasive positive pressure ventilation (NIPPV) in children with obstructive sleep apnea-hypopnea syndrome (OSAHS) and risk factors.

Methods: Twenty-one children with OSAHS and risk factors from March 2001 to December 2012 were enrolled in this study. They all received home-based remote monitoring NIPPV therapy.

Delayed diagnosis and treatment of foreign body aspiration in China: the roles played by physician inexperience and lack of bronchoscopy facilities at local treatment centers.

Objective: We examined if lack of on-site bronchoscopy facilities and the inexperience of initial treating physicians contributed to missed or delayed diagnosis of tracheobronchial foreign body aspiration (FBA) in pediatric patients presenting with respiratory distress.

Methods: The medical records of 340 patients examined by bronchoscopy in our otolaryngology department from January 2009 to August 2012 were reviewed. Age, gender, clinical history, findings on physical examination, facilities at the initial treatment site (bronchoscopy or not), bronchoscopic findings (type and location of the FB), and initial diagnosis, were examined in terms of the delay between initial treatment and bronchoscopy-based diagnosis of FBA.

[Clinical study of post-operative pain following coblation tonsillectomy and/or adenoidectomy in children with sleep-disordered breathing].

Objective: To explore the characteristics of post-operative pain following coblation tonsillectomy and/or adenoidectomy in children with sleep-disordered breathing (SDB) and explore the correlation between the first day post-operative pain scores and age and operating time.

Method: 1) A total of 113 SDB children scheduled to undergo coblation tonsillectomy and/or adenoidectomy were recruited. 113 children were divided into two groups according to the method of operation, children who underwent coblation tonsillectomy and adenoidectomy were enrolled in study group one and children who underwent coblation adenoidectomy only were in study group two.

Feasibility of a remote monitoring system for home-based non-invasive positive pressure ventilation of children and infants.

Objective: We examined the safety, efficacy, and caregiver satisfaction of a remote monitoring system for home-based non-invasive positive pressure ventilation of children and infants with upper airway obstruction.

Methods: Fourteen pediatric patients (age 50 days to 12 years) treated in our ENT unit from March 2009 to July 2011 and requiring home-based non-invasive positive pressure ventilation were enrolled in this feasibility study; one patient underwent CPAP and the other 13 patients underwent Bi-PAP. User satisfaction with the monitoring system was assessed by questionnaires given at regular intervals to parents and attending physicians.

[Application of minimally invasive technique of coblation in 30 infants with epiglottic cyst].

Objective: To present the efficacy of minimally invasive technology of coblation in the treatment of infant epiglottic cyst.

Methods: The clinical data of 30 infants with epiglottic cyst treated between January 2008 and January 2011 were reviewed retrospectively. All infants with epiglottic cyst were treated with the ArthroCare ENT Coblator II Surgery System after being checked completely.

[Study of arousal index in children with sleep-disordered breathing].

Objective: To explore which index is more suitable to show the degree of sleep fragment in children with sleep-disordered breathing (SDB).

Methods: Between October 2009 and August 2011, Forty-five children (4 - 8 years) who were diagnosed as obstructive sleep apnea hypopnea syndrome (OSAHS) were enrolled in OSAHS group[obstructive apnea index (OAI) > 1 times/h or apnea hypopnea index (AHI) > 5 times/h, lowest oxygen saturation (LSaO2) < 0.92] and 54 children were enrolled in SDB group (1 ≤ AHI ≤ 5 times/h and OAI ≤ 1 times/h), 18 children with chorditis nodules made up control group (AHI < 1 times/h and LSaO2 ≥ 0.

[Reasons of multiple operations in children with airway foreign body].

Objective: To explore the reasons of multiple operations in children with airway foreign body through analyzing the clinical data of children who received two or more operations.

Methods: From 2003 to 2009, all children with airway foreign body who received two or more operations in hospital were enrolled. The clinical manifestations, image before and after operation and intraoperative conditions were retrospectively analyzed, in order to find the reasons of multiple operations.

[Correlation between serum uric acid levels and obstructive sleep apnea/hypopnea syndrome in children].

Objective: To explore the level of serum uric acid (UA) in children with obstructive sleep apnea/hypopnea syndrome (OSAHS).

Method: Between Sep. 2008 and Mar.

[Diagnostic role of pulse transit time in children with sleep disordered breathing].

Objective: To explore the diagnostic value of pulse transit time (PTT) in children with sleep disordered breathing(SDB).

Methods: Forty eight randomly selected snorers (2 - 13 years) with SDB were examined by PSG and PTT in the same time. Data obtained were analyzed by different technicians respectively.

[Study on periodic limb movement during sleep in children with sleep-disordered breathing].

Objective: To explore the correlation between periodic limb movement index (PLMI) and the apnea-hypopnea index (AHI), apnea index (AI), hypopnea index (HI) and lowest oxygen saturation (LSaO₂) in sixty-four children with sleep-disordered breathing (SDB).

Methods: Between March 2008 and May 2009, sixty-four children suspected of OSAHS underwent overnight polysomnogram monitoring in our medicine sleep center. OSAHS was diagnosed according to the general criterion.

[Evaluation and analysis of auditory function and its clinical characteristics in low birth weight premature infants.].

Objective: To investigate and analyze dynamic changes of auditory function in premature babies with fetal age of less than 37 weeks who were categorized into different birth weight groups and to detect abnormalities of auditory function in these babies and to describe the early development patterns of auditory function in infancy.

Methods: Total of 252 subjects (504 ears) from neonatal ward, neonatal intensive care unit and auditory clinic in Guangzhou Children Hospital, whose fetal age were less than 37 weeks, were included in our study and received auditory function evaluation from January 2004 to February 2008. To investigate the correlation between birth weight and development and abnormality of auditory function in premature babies, all subjects were divided into four groups according to birth weight: View Article and Find Full Text PDF