Publications by authors named "Zhenyuan Shi"
Article Synopsis
- - USP21, a member of the Ubiquitin-specific peptidases (USPs), plays a critical role in various cellular processes like apoptosis and DNA repair, but research on it has been slow.
- - Over the past decade, studies have shown that USP21 helps remove ubiquitin from key proteins that affect cell functions related to diseases, especially various cancers.
- - The review highlights USP21's structure and its involvement in cancer development, along with promising advancements in small-molecule inhibitors aimed at targeting USP21 for potential cancer treatments.
Article Synopsis
- Breast cancer (BC) is the most commonly diagnosed cancer globally since 2020, and histone methylation plays a significant role in its development.
- Lysine-specific demethylase 1 (LSD1) is a key enzyme that removes methyl groups from histones and is implicated in cancer progression, particularly in breast cancer through various mechanisms.
- The review discusses LSD1's structure, its mechanisms of action in breast cancer, the potential of LSD1 inhibitors as a treatment, and the future challenges and opportunities in targeting LSD1 for BC therapy.
Genomic imprinting is an epigenetic phenomenon by which certain genes display differential expression in a parent-of-origin-dependent manner. Hundreds of imprinted genes have been identified from several plant species. Here, we identified, with a high level of confidence, 208 imprinted gene candidates from rice ().
View Article and Find Full Text PDFPseudomonas aeruginosa is a group of bacteria, which can be isolated from diverse ecological niches. P. aeruginosa strain F9676 was first isolated from a rice seed sample in 2003.
View Article and Find Full Text PDFGrain size determines grain weight and affects grain quality. Several major quantitative trait loci (QTLs) regulating grain size have been cloned; however, our understanding of the underlying mechanism that regulates the size of rice grains remains fragmentary. Here, we report the cloning and characterization of a dominant QTL, grain size on chromosome 2 (GS2), which encodes Growth-Regulating Factor 4 (OsGRF4), a transcriptional regulator.
View Article and Find Full Text PDFIdentification and characterization of Mini1, a gene regulating rice shoot development.
J Integr Plant Biol
February 2015
The aerial parts of higher plants are generated from the shoot apical meristem (SAM). In this study, we isolated a small rice (Oryza sativa L.) mutant that showed premature termination of shoot development and was named mini rice 1 (mini1).
View Article and Find Full Text PDFBackground: Flowering time, which is often associated with the length of the growth period in rice, determines the adaptability of a plant to various environments. However, little is known about how flowering-time genes affect panicle development and yield formation potential in rice after inducing the transition from vegetative growth to reproductive growth.
Results: To explore the relationship between floral induction and yield formation and the molecular mechanism of panicle development in rice, a novel mutant, ghd10, was identified from japonica variety Wuyunjing 7 plants subjected to ethyl methane sulfonate (EMS) treatment.