Publications by authors named "Zhenyuan Shi"

Article Synopsis
  • - USP21, a member of the Ubiquitin-specific peptidases (USPs), plays a critical role in various cellular processes like apoptosis and DNA repair, but research on it has been slow.
  • - Over the past decade, studies have shown that USP21 helps remove ubiquitin from key proteins that affect cell functions related to diseases, especially various cancers.
  • - The review highlights USP21's structure and its involvement in cancer development, along with promising advancements in small-molecule inhibitors aimed at targeting USP21 for potential cancer treatments.
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Article Synopsis
  • Breast cancer (BC) is the most commonly diagnosed cancer globally since 2020, and histone methylation plays a significant role in its development.
  • Lysine-specific demethylase 1 (LSD1) is a key enzyme that removes methyl groups from histones and is implicated in cancer progression, particularly in breast cancer through various mechanisms.
  • The review discusses LSD1's structure, its mechanisms of action in breast cancer, the potential of LSD1 inhibitors as a treatment, and the future challenges and opportunities in targeting LSD1 for BC therapy.
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Genomic imprinting is an epigenetic phenomenon by which certain genes display differential expression in a parent-of-origin-dependent manner. Hundreds of imprinted genes have been identified from several plant species. Here, we identified, with a high level of confidence, 208 imprinted gene candidates from rice ().

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Pseudomonas aeruginosa is a group of bacteria, which can be isolated from diverse ecological niches. P. aeruginosa strain F9676 was first isolated from a rice seed sample in 2003.

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Grain size determines grain weight and affects grain quality. Several major quantitative trait loci (QTLs) regulating grain size have been cloned; however, our understanding of the underlying mechanism that regulates the size of rice grains remains fragmentary. Here, we report the cloning and characterization of a dominant QTL, grain size on chromosome 2 (GS2), which encodes Growth-Regulating Factor 4 (OsGRF4), a transcriptional regulator.

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The aerial parts of higher plants are generated from the shoot apical meristem (SAM). In this study, we isolated a small rice (Oryza sativa L.) mutant that showed premature termination of shoot development and was named mini rice 1 (mini1).

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Background: Flowering time, which is often associated with the length of the growth period in rice, determines the adaptability of a plant to various environments. However, little is known about how flowering-time genes affect panicle development and yield formation potential in rice after inducing the transition from vegetative growth to reproductive growth.

Results: To explore the relationship between floral induction and yield formation and the molecular mechanism of panicle development in rice, a novel mutant, ghd10, was identified from japonica variety Wuyunjing 7 plants subjected to ethyl methane sulfonate (EMS) treatment.

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