Zimberelimab plus chemotherapy as the first-line treatment of malignant peritoneal mesothelioma: A case report and review of literature.

Background: Malignant peritoneal mesothelioma (MPeM) is a rare cancer with a poor prognosis at advanced stage, and the standard first-line treatment for inoperable patients is chemotherapy. Although combining programmed cell death 1 (PD-1) inhibitors with chemotherapy is generally considered safe and effective in several malignant solid tumors, there are few reports regarding initial immunochemotherapy in advanced MPeM.

Case Summary: Here, to our knowledge, we present the first case of a patient with epithelioid subtype MPeM, who was treatment-naïve and benefited from initial PD-1 inhibitor plus standard chemotherapy with a prolonged progression-free survival (PFS) and good tolerance.

Pr-doped CeF crystals: Analysis of optical traits and fluorescence from Pr: D level for visible and near-infrared lasers.

In this work, four Pr -doped CeF crystals with 0.2, 0.4, 0.

Overexpression of Activating Transcription Factor-2 (ATF-2) Activates Wnt/Ca Signaling Pathways and Promotes Proliferation and Invasion in Non-Small-Cell Lung Cancer.

Previous studies have suggested an association of the expression of activating transcription factor-2 (ATF-2) with the survival time and the activity of the Wnt/Ca signaling pathway in non-small-cell lung cancer (NSCLC). However, the exact role of ATF-2 in tumorigenesis and its underlying mechanism remains unclear. In this study, we study whether ATF-2 regulates the growth and reproduction of NSCLC cells through the Wnt/Ca pathway.

P53 suppresses the progression of hepatocellular carcinoma via miR-15a by decreasing OGT expression and EZH2 stabilization.

Existing literature has highlighted the tumour suppressive capacity of microRNA-15a (miR-15a); however, its role in hepatocellular carcinoma (HCC) remains relatively unknown. This study aimed to investigate the role of miR-15a in HCC and the associated underlying mechanism. Initially, RT-qPCR was performed to detect the expression of miR-15a in HCC tissues and cells.

Donafenib Versus Sorafenib in First-Line Treatment of Unresectable or Metastatic Hepatocellular Carcinoma: A Randomized, Open-Label, Parallel-Controlled Phase II-III Trial.

Purpose: Donafenib, a novel multikinase inhibitor and a deuterated sorafenib derivative, has shown efficacy in phase Ia and Ib hepatocellular carcinoma (HCC) studies. This study compared the efficacy and safety of donafenib versus sorafenib as first-line therapy for advanced HCC.

Patients And Methods: This open-label, randomized, parallel-controlled, multicenter phase II-III trial enrolled patients with unresectable or metastatic HCC, a Child-Pugh score ≤ 7, and no prior systemic therapy from 37 sites across China.

Spectral analyses of Dy/Sr: LaF and Dy/Ca: LaF mixed crystals for laser applications.

Mixed crystals of Dy/Sr: LaF and Dy/Ca: LaF were grown by Bridgman technique and their spectral properties were investigated. Spectra broadening and peak shifts were observed, indicating the co-doping of Sr/Ca brings about a more disordered local symmetry of Dy, which makes both crystals favorable for tunable lasing action. Low-temperature high resolution excitation and emission spectra were carried out for exploring the types of luminescent center of Dy in crystals.

Universal SMP gripper with massive and selective capabilities for multiscaled, arbitrarily shaped objects.

Grippers are widely used for the gripping, manipulation, and assembly of objects with a wide range of scales, shapes, and quantities in research, industry, and our daily lives. A simple yet universal solution is very challenging. Here, we manage to address this challenge utilizing a simple shape memory polymer (SMP) block.

Silencing of long noncoding RNA SRRM2-AS exerts suppressive effects on angiogenesis in nasopharyngeal carcinoma via activating MYLK-mediated cGMP-PKG signaling pathway.

Long noncoding RNAs (lncRNAs) play a crucial role in several malignances, involving nasopharyngeal carcinoma (NPC), a heterogeneous disease. This study investigated mechanism of serine/arginine repetitive matrix protein 2-alternative splicing (SRRM2-AS) in NPC cell proliferation, differentiation, and angiogenesis. Initially, differentially expressed lncRNAs were screened out via microarray analysis.

Spectroscopic properties analyses and laser characterization simulation of Er,Eu:YAP single crystal.

Er,Eu:YAlO (abbr. as Er,Eu:YAP) crystal was grown by the Czochralski technique for the first time. Its absorption and fluorescence spectra as well as the fluorescence decay curves were measured and investigated.

Nicotinamide N-methyltransferase enhances the progression of prostate cancer by stabilizing sirtuin 1.

A previous study demonstrated that nicotinamide N-methyltransferase (NNMT) is upregulated in the tissues of patients with prostate cancer (PCa); however, the specific underlying mechanism of this remains unclear. To begin with, the expression of NNMT was investigated in the peripheral blood of patients with PCa and of healthy control subjects. The results indicated that the expression level of NNMT was elevated in the peripheral blood and tissues of patients with PCa.

Crystal growth, structure and characterization of ErBO as self-activated eye-safe laser material within the near-infrared waveband.

A new rare-earth borate ErBO was synthesized by a solid-state reaction technique. The crystal was obtained by a flux method. Single-crystal X-ray diffraction analysis revealed that the crystal structure is composed of ErO polyhedra sharing edges and BO groups.

High performance of a passively Q-switched mid-infrared laser with BiTe/graphene composite SA.

We report passively Q-switched ∼2 and ∼3  μm mid-infrared (MIR) solid-state lasers with a self-assembly solvothermal-synthesized BiTe/graphene heterostructure saturable absorber (SA) for the first time. Based on the oxidation resistance and high thermal conductivity of graphene, and large modulation depth of BiTe nanosheets, two high-performance Q-switching lasers were realized. One is a Tm:YAP laser with a maximum average output power of 2.

Activating transcription factor 2 expression mediates cell proliferation and is associated with poor prognosis in human non-small cell lung carcinoma.

Activating transcription factor 2 (ATF2) is a member of the cAMP response element binding protein family that heterodimerizes and activates other transcription factors involved in stress and DNA damage responses, growth, differentiation and apoptosis. ATF2 has been investigated as a potential carcinogenic biomarker in certain types of cancer, such as melanoma. However, its function and clinical significance in non-small cell lung cancer (NSCLC) has not been well studied.

Ultrasensitive nonlinear absorption response of large-size topological insulator and application in low-threshold bulk pulsed lasers.

Dirac-like topological insulators have attracted strong interest in optoelectronic application because of their unusual and startling properties. Here we report for the first time that the pure topological insulator Bi2Te3 exhibited a naturally ultrasensitive nonlinear absorption response to photoexcitation. The Bi2Te3 sheets with lateral size up to a few micrometers showed extremely low saturation absorption intensities of only 1.

Single-longitudinal-mode Er:GGG microchip laser operating at 2.7 μm.

We reported on a diode-end-pumped single-longitudinal-mode microchip laser using a 600-μm-thick Er:GGG crystal at ∼2.7  μm, generating a maximum output power of 50.8 mW and the maximum pulsed energy of 0.

Dual function of Nd3+ in Nd,Er:LuYSGG crystal for LD pumped ~3.0 μm mid-infrared laser.

Enhanced ~3.0 μm emission corresponding to Er3+:4I11/2→4I13/2 was achieved in Nd3+/Er3+ co-doped Lu0.15Y2.

2.4 W highly efficient simultaneous dual-wavelength laser operation of monoclinic Yb(3+):Ca4LaO(BO3)3 crystals.

We have studied the simultaneous dual-wavelength laser operation of the X-cut, Y-cut, and Z-cut Yb(3+):Ca4LaO(BO3)3 crystals for the first time to the best of our knowledge. We analyzed the dual-wavelength laser output power and emission spectra under several output coupler transmittances. The stable dual-wavelength lasers were generated by adjusting the laser elements.

Analyzing the differentially expressed genes and pathway cross-talk in aggressive breast cancer.

Aim: The aim of this study was to explore the genes and pathways involved in the aggressive breast cancer cells.

Methods: The gene expression profiles of GSE40057, including four aggressive breast cell lines and six less aggressive cell lines, were downloaded from the Gene Expression Omnibus (GEO) database. The gene differential expression analysis was carried out with limma software with the method of Bayes for multiple tests.

The novel role of thymopentin in induction of maturation of bone marrow dendritic cells (BMDCs).

Thymopentin is an immune-modulating peptide that can stimulate cellular immune responses and has been used in many immune handicapped cases [1]. However, despite documented reports proving its efficacy in immunoregulation, there have been no reports, as yet, concerning its impact on the maturation and function of dendritic cells (DCs). In this study, we analyzed the effects of thymopentin on the detailed regulation of maturation of murine bone-marrow-derived DCs (BMDCs).

Self-Q-switched, orthogonally polarized, dual-wavelength laser using long-lifetime Yb³⁺ crystal as both gain medium and saturable absorber.

A novel self-Q-switched and orthogonally polarized dual-wavelength laser has been investigated with Yb³⁺-doped CGB disordered crystals. By slightly inclining output coupler to introduce the Fresnel loss, we realized simultaneously dual-wavelength laser operation at 1052.6 nm in E//b polarization and 1057.

Activation effect of Ho3+ at 2.84 μm MIR luminescence by Yb3+ ions in GGG crystal.

The use of Yb(3+) co-doping for the enhancement of Ho(3+):(5)I(6)→(5)I(7) mid-IR (MIR) emissions was investigated in GGG crystal for the first time. It is established that Yb(3+) highly increases Ho(3+) 2.84 μm emissions by transforming pump energy from the Yb(3+):(2)F(5/2) level to the laser upper level (5)I(6) of Ho(3+).

Output-coupling-dependent laser operation of monoclinic Yb:Ca4LaO(BO3)3 crystal.

We have studied the laser operation of Yb:LaCOB crystal for what we believe is the first time. Adopting a plane-concave cavity, the laser properties were measured for the X-cut, Y-cut, and Z-cut crystals. The best output power of 3.

Benefit of Pr3+ ions to the spectral properties of Pr3+/Er3+:CaGdAlO4 crystal for a 2.7 μm laser.

The spectra of Er3+:CaGdAlO4 and Pr3+/Er3+:CaGdAlO4 crystals were measured under the same conditions. With the presence of Pr3+ ions, the intensities of the green, red upconversion and near-infrared emissions are dramatically reduced to 1/20, 1/150, and 1/8.5 of those for Er3+:CaGdAlO4.

White up-conversion luminescent property in Re3+:Gd3Ga5O12 nanocrystals.

Rare-earth ions doped Gd3Ga5O12 nanocrystals have been prepared by a propellant combustion synthesis method and their up-conversion properties were systematically investigated in this paper. XRD, SEM, TEM, and up-conversion emission spectra were used to characterize the synthesized nanocrystals. Energy transfer from Yb3+ to Er3+ and Tm3+ can occur simultaneously in the as-synthesized Gd3Ga5O12 nanocrystals.

EGFR inhibitor C225 increases the radiosensitivity of human lung squamous cancer cells.

Background: The purpose of the present study is to investigate the direct biological effects of the epidermal growth factor receptor (EGFR) inhibitor C225 on the radiosensitivity of human lung squamous cancer cell-H520. H520 cells were treated with different dosage of 60Co γ ray irradiation (1.953 Gy/min) in the presence or absence of C225.