Publications by authors named "Zhenyu Yin"

Hepatocellular carcinoma (HCC) is a highly potent malignancy. The enzyme coactivator-associated arginine methyltransferase 1 (CARM1) is highly expressed in different types of cancer. However, the precise levels of expression, clinical significance, biological functions, and molecular mechanisms of CARM1 in HCC, particularly related to the downstream genes regulated by CARM1 through histone arginine methylation, remain unclear.

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With the advent of an aging population, the study of aging and related research has been increasingly prominent, focusing on how to fully understand and delay aging-a key concern for contemporary medical professionals. Stroke is an acute focal neurological deficit. Globally, ischemic stroke accounts for only 60-70% of all strokes, meanwhile, it is the second leading cause of death.

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Piezoelectric inkjet printing technology, known for its high precision and cost-effectiveness, has found extensive applications in various fields. However, the issue of residual vibration significantly limits its printing quality and efficiency. This paper presents a method for suppressing residual vibration based on the particle swarm optimization (PSO) algorithm.

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Hepatocellular carcinoma (HCC) is a prevalent malignant tumor worldwide. Tripartite motif containing 55 (TRIM55), also known as muscle-specific ring finger 2 (Murf2), belongs to the TRIM protein family and serves as an E3 ligase. Recently, the function and mechanism of TRIM55 in the advancement of solid tumors have been elucidated.

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UBE2C, a ubiquitin-conjugating enzyme, functions as an oncogene in different types of human cancers. Nonetheless, the exact influence of UBE2C on the development of HCC via regulation of ubiquitination remains uncertain. Here, we found that UBE2C displayed elevated levels of expression in HCC and was associated with an unfavorable prognosis, as evidenced by the analysis of the TCGA database and the examination of clinical specimens.

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  • Necrotizing fasciitis (NF) is a rare but serious infection that causes rapid tissue death in various body areas, particularly in male genital and groin regions, often triggered by multiple types of bacteria.
  • While NF can sometimes be linked to tumor sites like rectal or sigmoid colon cancer and issues related to targeted therapy drugs, cases showing NF with these cancers without prior perforation highlight a complex relationship.
  • Two patient cases further illustrate the link between targeted therapy and NF, with one developing it after immunotherapy for rectal cancer and another after treatment for hepatocellular carcinoma, suggesting targeted cancer therapies may elevate the risk of developing NF.
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  • * Neoadjuvant therapies like photodynamic therapy (PDT) are used to shrink tumors and alleviate obstructions, thereby paving the way for surgery and improving surgical outcomes.
  • * Robotic surgery combined with fluorescent laparoscopic techniques enhances precision and effectiveness in treating colon cancer, as demonstrated in a case where a patient with obstructive colon cancer successfully underwent this combined approach after PDT treatment.
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  • Genetic sequencing advancements have improved immunotherapy for colorectal cancer (CRC), especially in patients with microsatellite instability (MSI)-High or DNA polymerase epsilon (POLE) mutations.
  • While initial trials show promise, the overall response rates to these treatments remain low, presenting challenges in real-world applications.
  • A case study reports a CRC patient with MSI-High and POLE mutation who experienced a rapid response to immunotherapy combined with photodynamic therapy (PDT), suggesting that these treatments work well together, with MSI and POLE status potentially indicating better survival outcomes.
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  • The study investigates the role of human-induced pluripotent stem cell-derived neural stem cell exosomes (hiPSC-NSC-Exos) in protecting the blood-brain barrier after intracerebral hemorrhage, a condition that can lead to poor patient outcomes.
  • Results showed that intranasal administration of hiPSC-NSC-Exos improved neurological function, strengthened blood-brain barrier integrity, and reduced inflammation in mice, highlighting their therapeutic potential.
  • The mechanism revealed that hiPSC-NSC-Exos activated the PI3K/AKT signaling pathway in astrocytes, which led to decreased secretion of inflammatory proteins like monocyte chemoattractant protein-1, ultimately aiding in barrier preservation
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Background: OA imposes a heavy burden on patients and society in that its mechanism is still unclear, and there is a lack of effective targeted therapy other than surgery.

Methods: The osteoarthritis dataset GSE55235 was downloaded from the GEO database and analyzed for differential genes by limma package, followed by analysis of immune-related modules by xcell immune infiltration combined with the WGCNA method, and macrophage polarization-related genes were downloaded according to the Genecard database, and VennDiagram was used to determine their intersection. These genes were also subjected to gene ontology (GO), disease ontology (DO), and Kyoto Encyclopedia of Genes and Genomes (KEGG) functional enrichment analyses.

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  • The Pearl River Estuary (PRE) is a major global e-waste recycling hub facing pollution from Liquid Crystal Monomers (LCMs), toxic substances found in electronic devices.
  • Dredging activities for coastal land reclamation in the region increase sediment re-suspension, which can harm marine life and ecosystems.
  • This study introduces a new risk assessment strategy using machine learning and simulations to evaluate the effects of dredging operations on sediment contamination and its impact on the local marine environment.
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Microglia play a pivotal role in the neuroinflammatory response after brain injury, and their proliferation is dependent on colony-stimulating factors. In the present study, we investigated the effect of inhibiting microglia proliferation on neurological damage post intracerebral hemorrhage (ICH) in a mouse model, an aspect that has never been studied before. Using a colony-stimulating factor-1 receptor antagonist (GW2580), we observed that inhibition of microglia proliferation significantly ameliorated neurobehavioral deficits, attenuated cerebral edema, and reduced hematoma volume after ICH.

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  • - The study investigates how long-term exposure to polysorbate 80 (P80), an emulsifier in food and pharmaceuticals, affects gut microbiota and cognitive function in aging mice.
  • - Results show that P80 intake worsened cognitive decline and led to increased brain pathology, gut microbiota imbalance, and changes in bile acid metabolism in the mice.
  • - The findings suggest that P80-induced gut dysbiosis and related metabolic changes may disrupt the intestinal and blood-brain barriers, contributing to neuroinflammation and accelerated cognitive decline in aging individuals.
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JOURNAL/nrgr/04.03/01300535-202409000-00033/figure1/v/2024-01-16T170235Z/r/image-tiff We previously reported that miR-124-3p is markedly upregulated in microglia-derived exosomes following repetitive mild traumatic brain injury. However, its impact on neuronal endoplasmic reticulum stress following repetitive mild traumatic brain injury remains unclear.

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HSPA13, an important member of the heat shock protein family, plays an essential role in the oncogenesis of many organs, but the mechanism and function in hepatocellular carcinoma (HCC) is still unclear. In the present study, we found that HSPA13 was highly expressed in HCC and predicted poor clinical prognosis. Upregulation of HSPA13 was significantly associated with vascular invasion in HCC patients.

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The immunomodulatory effect of divalent manganese cations (Mn ), such as activation of the cGAS-STING pathway or NLRP3 inflammasomes, positions them as adjuvants for cancer immunotherapy. In this study, it is found that trace Mn ions, bound to bovine serum albumin (BSA) to form Mn@BSA nanocomplexes, stimulate pro-inflammatory responses in human- or murine-derived macrophages through TLR4-mediated signaling cascades. Building on this, the assembly of Mn@BSA nanocomplexes to obtain nanowire structures enables stronger and longer-lasting immunostimulation of macrophages by regulating phagocytosis.

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  • Primary liver cancer is a major health concern in China, with hepatocellular carcinoma accounting for 75-85% of cases, ranking as the fourth most common cancer and the second leading cause of cancer-related deaths in the country.
  • The Guidelines for Diagnosis and Treatment of Primary Liver Cancer were first published in 2017 and have been updated due to new research and evidence in the field, leading to the 2022 Edition written by over 100 experts.
  • The updated guidelines aim to promote evidence-based practices to enhance the 5-year survival rate of liver cancer patients in alignment with the "Health China 2030 Blueprint."
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Small extracellular vesicles(sEVs), a subset of extracellular vesicles with a bilateral membrane structure, contain biological cargoes, such as lipids, nucleic acids, and proteins. sEVs are crucial mediators of intercellular communications in the physiological and pathological processes of the central nervous system. Because of the special structure and complex pathogenesis of the brain, central nervous system disorders are characterized by high mortality and morbidity.

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Edge detection is a crucial step in many computer vision tasks, and in recent years, models based on deep convolutional neural networks (CNNs) have achieved human-level performance in edge detection. However, we have observed that CNN-based methods rely on pre-trained backbone networks and generate edge images with unwanted background details. We propose four new fusion difference convolution (FDC) structures that integrate traditional gradient operators into modern CNNs.

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Rolling bearing fault diagnosis is of great significance to the safe and reliable operation of manufacturing equipment. In the actual complex environment, the collected bearing signals usually contain a large amount of noises from the resonances of the environment and other components, resulting in the nonlinear characteristics of the collected data. Existing deep-learning-based solutions for bearing fault diagnosis perform poorly in classification performance under noises.

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Metastasis to the liver, as one of the most frequent metastatic patterns, was associated with poor prognosis. Major drawbacks of conventional therapies in liver metastasis were the lack of metastatic-targeting ability, predominant systemic toxicities and incapability of tumor microenvironment modulations. Lipid nanoparticles-based strategies like galactosylated, lyso-thermosensitive or active-targeting chemotherapeutics liposomes have been explored in liver metastasis management.

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Background And Aims: Lenvatinib is a first-line drug commonly used in the treatment of advanced hepatocellular carcinoma (HCC). However, its clinical efficacy is very limited due to drug resistance. Therefore, there is a great need to explore its combination with other agents to achieve better therapeutic effects.

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Neural inflammatory response is a crucial pathological change in intracerebral hemorrhage (ICH) which accelerates the formation of perihematomal edema and aggravates neural cell death. Although surgical and drug treatments for ICH have advanced rapidly in recent years, therapeutic strategies that target and control neuroinflammation are still limited. Exosomes are important carriers for information transfer among cells.

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Aims: Neuropathic pain after spinal cord injury (SCI) remains a common and thorny problem, influencing the life quality severely. This study aimed to elucidate the reorganization of the primary sensory cortex (S1) and the regulatory mechanism of the lateral parabrachial nucleus (lPBN) in the presence of allodynia or hyperalgesia after left spinal cord hemisection injury (LHS).

Methods: Through behavioral tests, we first identified mechanical allodynia and thermal hyperalgesia following LHS.

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Natural killer(NK) cells comprise one subset of the innate lymphoid cells family. Despite reported anti-tumor activity of NK cells, their tangible contribution to tumor control remains controversial. This is due to the incomplete understanding of NK alterations within tumor microenvironment(TME).

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Synopsis of recent research by authors named "Zhenyu Yin"

  • - Zhenyu Yin's recent research encompasses a diverse array of topics, with a notable focus on the intersection of biomedical sciences and engineering, particularly in understanding and mitigating diseases such as ischemic stroke and hepatocellular carcinoma through various cellular mechanisms and therapeutic approaches.
  • - His work on ischemic stroke highlights the urgency of addressing age-related health issues, while research on hepatocellular carcinoma elucidates the roles of specific proteins, such as TRIM55 and UBE2C, in cancer progression and response, potentially paving the way for novel therapeutic targets.
  • - Additionally, Yin has explored innovative methodologies in medical treatments and applications, including the improvement of printing technology through vibration suppression and the utilization of human-induced pluripotent stem cell-derived exosomes for brain injury repair, demonstrating a commitment to advancing precision medicine and addressing environmental health concerns, such as e-waste pollution.

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