[Dietary diversity and micronutrients adequacy among women of reproductive age in China in 2015-2017].

Objective: To describe the dietary diversity and micronutrients adequacy among women of reproductive age during 2015-2017 in China.

Methods: Data was from the China Nutrition and Health Surveillance in 2015-2017. Stratified multistage cluster sampling method was used, and 17622 women aged 15-49 years from 31 provinces(autonomous regions and municipalities) were involved.

High Current Gain MoS Bipolar Junction Transistor Based on Metal-Semiconductor Schottky Contacts.

Bipolar junction transistors (BJTs) are crucial components in high-power electronic applications. However, while two-dimensional (2D) semiconductors with exceptional electrical properties have been extensively studied in field-effect transistors, their application in BJTs has received far less attention. In this study, we demonstrate high-gain MoS BJTs based on metal-semiconductor Schottky contacts.

Targeting programmed cell death in diabetic kidney disease: from molecular mechanisms to pharmacotherapy.

Diabetic kidney disease (DKD), one of the most prevalent microvascular complications of diabetes, arises from dysregulated glucose and lipid metabolism induced by hyperglycemia, resulting in the deterioration of renal cells such as podocytes and tubular epithelial cells. Programmed cell death (PCD), comprising apoptosis, autophagy, ferroptosis, pyroptosis, and necroptosis, represents a spectrum of cell demise processes intricately governed by genetic mechanisms in vivo. Under physiological conditions, PCD facilitates the turnover of cellular populations and serves as a protective mechanism to eliminate impaired podocytes or tubular epithelial cells, thereby preserving renal tissue homeostasis amidst hyperglycemic stress.

The immune regulatory role of exosomal miRNAs and their clinical application potential in heart failure.

Heart failure (HF) is a complex and debilitating condition characterized by the heart's inability to pump blood effectively, leading to significant morbidity and mortality. The abnormality of immune response is a key factor in the progression of HF, contributing to adverse cardiac remodeling and dysfunction. Exosomal microRNAs (miRNAs) play a pivotal role in regulating gene expression and cellular function, which are integral to the crosstalk between cardiac and immune cells, influencing immune cell functions, such as macrophage polarization, T cell activity, and cytokine production, thereby modulating various pathological processes of HF, such as inflammation, fibrosis, and cardiac dysfunction.

Mesenchymal Stem Cells Prevent SLC39A14-Dependent Hepatocyte Ferroptosis through Exosomal miR-16-5p in Liver Graft.

Ischemia-reperfusion injury (IRI) is the leading cause of hepatic graft dysfunction, resulting from hepatocyte damage. Nevertheless, given the few specialized therapeutics available in hepatic IRI, additional mechanistic insights into hepatocyte damage are required. Here, the protein solute carrier family 39 member 14 (SLC39A14) is identified as a pro-ferroptosis target in hepatocytes of human liver allografts through single-cell RNA sequencing analysis.

Tailoring the pulse characteristics of LiBO-based femtosecond optical parametric oscillators by temperature tuning.

We show that the phase mismatch in LiBO (LBO) crystals is approximately proportional to the temperature deviation from the phase-matching temperature of crystals. Moreover, a fixed temperature deviation would result in approximately the same amount of phase mismatch over a large range of wavelengths. Based on this, we demonstrate that the pulse characteristics of LBO-based femtosecond optical parametric oscillators (OPOs) can be tailored by simply tuning the crystal temperature.

Starfish-Inspired Solid-State Li-ion Conductive Membrane with Balanced Rigidity and Flexibility for Ultrastable Lithium Metal Batteries.

The performance of solid-state lithium-metal batteries (SSLMB) is often constrained by the low ionic conductivity, narrow electrochemical window, and insufficient mechanical strength of polyethylene oxide (PEO)-based electrolytes. Inspired by the soft-outside, rigid-inside structure of starfish, we designed multifunctional "starfish-type" composite polymer electrolytes (CPEs) using electrospinning technology. These CPEs feature a three-dimensional rigid skeleton network composed of polyacrylonitrile/metal-organic frameworks/ionic liquids (PAN/MOFs/ILs), creating continuous and efficient Li transport channels: MOFs impart rigidity, PEO acts as a cushioning outer layer to enhance interfacial compatibility, and ILs reduce interfacial resistance.

A New Azaphilone From the Marine Sponge-Associated Fungus Botryosporium pulchrum.

A new azaphilone, botryazaphilone (1), the first example of azaphilone featuring a 6/6/5/5 tetracyclic system, together with two known ones, chermesinone A (2) and perangustol B (3), had been obtained from the marine sponge-associated fungus Botryosporium pulchrum. The structure of 1 was elucidated through the analysis of spectroscopic data, whereas its absolute configuration was determined via single-crystal x-ray diffraction. It is the first report of the secondary metabolites isolated from the genus Botryosporium.

Probiotics Combined with Metformin Improves Sperm Parameters in Obese Male Mice through Modulation of Intestinal Microbiota Equilibrium.

The decline in sperm parameters among obese males has attracted significant scholarly interest. The intestinal microbiota plays a crucial role in obesity, and investigating the intestinal-reproductive axis may offer a novel molecular approach to addressing the decline in male sperm parameters caused by obesity. To clarify whether probiotics, either alone or in conjunction with metformin, can enhance sperm parameters in obese male mice and assess the underlying mechanisms involved.

Integrated analyses of multi-omic data derived from paired primary lung cancer and brain metastasis reveal the metabolic vulnerability as a novel therapeutic target.

Background: Lung cancer brain metastases (LC-BrMs) are frequently associated with dismal mortality rates in patients with lung cancer; however, standard of care therapies for LC-BrMs are still limited in their efficacy. A deep understanding of molecular mechanisms and tumor microenvironment of LC-BrMs will provide us with new insights into developing novel therapeutics for treating patients with LC-BrMs.

Methods: Here, we performed integrated analyses of genomic, transcriptomic, proteomic, metabolomic, and single-cell RNA sequencing data which were derived from a total number of 154 patients with paired and unpaired primary lung cancer and LC-BrM, spanning four published and two newly generated patient cohorts on both bulk and single cell levels.

Prognostic effectiveness of interactive vs. non-interactive mobile app interventions in type 2 diabetes: a systematic review and meta-analysis.

Background: Mobile app interventions are emerging as significant tools in managing the prognosis of type 2 diabetes, demonstrating progressively greater impacts. The effectiveness of these interventions needs further evidence-based support.

Objective: This study conducted a systematic review and meta-analysis of randomized controlled trials to evaluate the effectiveness of mobile app interventions in improving prognosis for patients with type 2 diabetes.

Respiratory endoscopy intervention in 12 patients with refractory persistent air leakage after pulmonary surgery: a preliminary study of case series.

Objective: To explore the value of our protocol of respiratory endoscopy intervention in the treatment of refractory persistent air leakage(PAL) after pulmonary surgery.

Method: A retrospective study was conducted in 12 patients with PAL after pulmonary surgery who were successfully treated by our protocol of respiratory endoscopy intervention in the Department of Respiratory and Critical Care Medicine of the Fourth Hospital Affiliated to Soochow University and the First Hospital Affiliated to Soochow University from December 2019 to January 2024. 4 types of treatment were included in our protocol; A: chest tube drainage combined with negative pressure suction; B: medical thoracoscopy with chest tube as a path; C: stimulating bronchial mucosa hyperplasia under bronchoscopy; D: blocking of the fistula orifice with the relevant materials under the bronchoscope; And the specific treatment received by each patient was based on the condition of the patient.

Integrated bioinformatics and machine learning algorithms reveal the unfolded protein response pathways and immune infiltration in acute myocardial infarction.

Background: The unfolded protein response (UPR) is a critical biological process related to a variety of physiological functions and cardiac disease. However, the role of UPR-related genes in acute myocardial infarction (AMI) has not been well characterized. Therefore, this study aims to elucidate the mechanism and role of the UPR in the context of AMI.

Comprehensive effects of tea branch biochar on antibiotic resistance profiles and C/N/S cycling in the compost microbiota of animal manure.

The comprehensive effects of exogenous additives on microbial-driven antibiotic resistance profiles and C/N/S conversion in animal manure composting remains uncertain. This study examined whether tea branch biochar could regulate the microflora involved in antibiotic resistance and C/N/S conversion during pig and chicken manure composting. Compared with the control treatment, biochar addition prolonged the high-temperature period (>55 °C) for 1-2 days and raised the maximum temperature in chicken manure composting.

The noncanonical RNA-binding protein RAN stabilizes the mRNA of intranuclear stress granule assembly factor G3BP1 in nasopharyngeal carcinoma.

RNA-binding proteins (RBPs) play critical roles in tumor progression by participating in the posttranscriptional regulation of RNA. However, the levels and function of RBPs in nasopharyngeal carcinoma (NPC) remain elusive. Here we identified a noncanonical RBP RAN that has the most significant role in NPC progression by a small siRNA pool screening.

Clinical Analysis of 32 Cases of Subglottic Benign Airway Stenosis Treated With Montgomery T Silicone Stent.

To explore the complications of long-term placement of Montgomery T silicone stent (Ttube) in the treatment of subglottic benign airway stenosis (SBAS) and the timing of successful Ttube removal. We retrospectively collected the clinical data of 32 patients with SBAS who underwent the treatment of Ttube and analyzed their placement and successful removal of the Ttube. There were 22 males and 10 females, aged from 21 to 79 years (60.

Ten-year survival outcomes of video-assisted thoracic surgery open major lung resection for stage I-III non-small cell lung cancer: a large cohort study in China.

Background: Despite the widespread adoption of video-assisted thoracoscopic surgery (VATS) for major lung resection, the 10-year long-term survival outcomes of non-small cell lung cancer (NSCLC) treated with VATS compared with open major lung resection is lacking. The purpose of this study was to analyze the short- and long-term outcomes of VATS open major lung resection for NSCLC.

Methods: The perioperative outcomes and long-term survival of p-stage I-III NSCLC patients who underwent major lung resection via VATS open major lung resection in the Western China Lung Cancer Database (WCLCD) between May 2006 and June 2018 were studied using propensity score matching (PSM).

Macrophage-Derived Exosomes Promoted the Development and Stemness of Inflammatory Bowel Disease-Related Colorectal Cancer via nuclear paraspeckle assembly transcript 1-Mediated miRNA-34a-5p/phosphoprotein enriched in astrocytes 15 Axis.

Background: Inflammatory bowel disease (IBD) is closely associated with the development of colorectal cancer (CRC) due to the chronic inflammatory response. Macrophages play critical roles in regulating the microenvironment to facilitate tumor progression. Exosomes are key modulators for the communication between macrophages and tumor cells.

Study on Vitamin K Levels in Mature Milk of Chinese Lactating Mothers.

Objectives: This study sought to understand the levels of vitamin K in the mature milk of Chinese lactating mothers, thereby providing a foundation for the development of appropriate intake (AI) of vitamin K for infants aged 0-5 months.

Methods: Five hundred healthy lactating mothers were selected from the mature milk bank established by the Chinese Maternal and Infant Nutrition and Health Cohort by using a simple random sample procedure. Relevant information about lactating mothers and their infants was obtained by a questionnaire survey.

The correlation of the liquidus curves and valence electron structures of a ternary lithium halide molten-salt electrolyte for liquid metal batteries.

Liquid metal batteries have received considerable attention owing to their excellent properties. However, an electrolyte with low melting temperature is required to decrease operating temperature for the safety of liquid metal batteries and for saving energy. For revealing the mechanism of low liquefaction temperature, an empirical electron theory of solid molecules was used to study the thermal properties of pure lithium halides and their ternary-phase systems systematically.

Study on the complications after implantation of different types of metal stents in rabbit trachea.

Objective: To observe the complications and inflammatory responses caused by the different types of metal stents in the trachea of rabbits.

Method: 79 rabbits were randomly divided into 4 groups and were implanted with the customized nickel-titanium alloy metal stents(fully covered metal stent: group A, bare metal stent: group B, segmented covered metal stent: group C and control group: group D). The complications (tracheal deformation, granulation tissue hyperplasia, scar hyperplasia and secretion retention) of different types of metal stents were compared by observing the anatomical and pathological specimens of dead rabbits; And the expression of inflammatory factors of different types of metal stents were compared by detecting the tissue of tracheas of dead rabbits.

A Novel Multi-Dimensional Joint Search Method for the Compression of Medical Image Segmentation Models.

Due to the excellent results achieved by transformers in computer vision, more and more scholars have introduced transformers into the field of medical image segmentation. However, the use of transformers will make the model's parameters very large, which occupies a large amount of the computer's resources, making them very time-consuming during training. In order to alleviate this disadvantage, this paper explores a flexible and efficient search strategy that can find the best subnet from a continuous transformer network.

A Comprehensive Proteogenomic and Spatial Analysis of Innate and Acquired Resistance of Metastatic Melanoma to Immune Checkpoint Blockade Therapies.

Unlabelled: While a subset of patients with metastatic melanoma achieves durable responses to immune checkpoint blockade (ICB) therapies, the majority ultimately exhibit either innate or acquired resistance to these treatments. However, the molecular mechanisms underlying resistance to ICB therapies remain elusive and are warranted to elucidate. Here, we comprehensively investigated the tumor and tumor immune microenvironment (TIME) of paired pre- and post-treatment tumor specimens from metastatic melanoma patients who were primary or secondary resistance to anti-CTLA-4 and/or anti-PD-1/PD-L1 therapies.