CircRUNX1 enhances the Warburg effect and immune evasion in non-small cell lung cancer through the miR-145/HK2 pathway.

Non-small cell lung cancer (NSCLC) is acknowledged as the primary subtype of lung cancer. The Warburg effect, marked by elevated glucose consumption and lactate fermentation, is a prevalent characteristic of NSCLC. The mechanisms by which circRNA mediates the regulation of the Warburg effect and immune evasion in NSCLC remain unclear.

Morphology-/microstructure-regulated nickel/nitrogen-co-doped monodisperse hollow carbon spheres for controlled electrochemical CO reduction to syngas.

Monodisperse carbon materials have attracted increasing attention in the fields of catalysis, adsorption, and energy storage. However, the preparation of monodisperse microstructure-controlled carbon spheres still faces tremendous challenges due to the complexity of involved polymerization/carbonization processes and the difficulty of controlling high monodispersity and regulating microstructures, which are vital for ensuring a uniform packing, determining consistent physical and chemical properties and targeting applications. Here, we report an approach to address these issues by co-doping nickel and nitrogen into an aminophenol-formaldehyde resin (APFR) polymer framework.

Machine Learning-Enhanced Extraction of Protein Signatures of Renal Cell Carcinoma from Proteomics Data.

In this study, we generated label-free data-independent acquisition (DIA)-based liquid chromatography (LC)-mass spectrometry (MS) proteomics data from 261 renal cell carcinomas (RCC) and 195 normal adjacent tissues (NAT). The RCC tumors included 48 non-clear cell renal cell carcinomas (non-ccRCC) and 213 ccRCC. A total of 219,740 peptides and 11,943 protein groups were identified with 9,787 protein groups per sample on average.

THBS1 in macrophage-derived exosomes exacerbates cerebral ischemia-reperfusion injury by inducing ferroptosis in endothelial cells.

Macrophages play a critical role in the development of acute ischemic stroke (AIS). Cerebral ischemia-reperfusion injury (CIRI) is a pivotal pathological process that exacerbates AIS, with exosomes act as crucial mediators. However, the effects and mechanisms of action of macrophage-derived exosomes on CIRI remain unclear.

DeepPrep: an accelerated, scalable and robust pipeline for neuroimaging preprocessing empowered by deep learning.

Neuroimaging has entered the era of big data. However, the advancement of preprocessing pipelines falls behind the rapid expansion of data volume, causing substantial computational challenges. Here we present DeepPrep, a pipeline empowered by deep learning and a workflow manager.

Association of workforce participation with depression among US older adults: results from NHANES 2005-2018.

Background: The challenges of global aging would boost more workforce participation of older adults, and depression rate was increasing among older adults. This study aimed to explore the associations of workforce participation with depression among US older adults.

Methods: This cross-sectional study used data from the National Health and Nutrition Examination Survey (NHANES) 2005-2018.

Significance of TYMS Polymorphism rs3819102 as a Prognostic Marker for Nonsmoking Lung Cancer Patients of the Han Ethnicity in China.

Introduction: With high incidence and mortality rates, lung cancer is now one of the most common cancers in the world. The 5-year survival rate of lung cancer patients is very low, and predicting the prognosis of lung cancer patients and using it to develop treatment strategies and interventions is important for prolonging the survival time of patients. Folate metabolism involves various aspects such as methylation of DNA, RNA, proteins, lipids, etc.

Aggressiveness of f. sp. Isolates at High Temperatures: A Study Case in Core Oversummering Area of Gansu as Inoculum Source.

Wheat stripe rust, caused by a biotrophic, obligate fungus f. sp. (), is a destructive wheat fungal disease that exists worldwide and caused huge yield reductions during pandemic years.

Ferritinophagy promotes microglia ferroptosis to aggravate neuroinflammation induced by cerebral ischemia-reperfusion injury via activation of the cGAS-STING signaling pathway.

Cerebral ischemia-reperfusion injury (CIRI) is a common and serious complication of reperfusion therapy in patients with ischemic stroke (IS). The regulation of microglia-mediated neuroinflammation to control CIRI has garnered considerable attention. The balance of iron metabolism is key to maintaining the physiological functions of microglia.

Prognostic Significance of Polymorphism rs140693 and Clinical Characteristics in Chinese Lung Cancer Patients.

Unlabelled: Lung cancer remains the leading cause of death among cancer patients, and the five-year survival rate is less than 25%. However, () polymorphism rs140693 predicts the prognosis of lung cancer patients still needs further verification. Primary lung cancer patients ( = 839) were collected from two hospitals, genomic DNA was extracted from blood, and genotyping was performed using SNPcan technology.

Wilms' tumor 1-associated protein aggravates ischemic stroke by promoting M1 polarization of microglia by enhancing PTGS2 mRNA stability in an m6A-dependent manner.

Mounting evidence indicates the involvement of N6-methyladenosine (m6A) alterations in diverse neurological disorders and the activation of microglia. However, the role of m6A methyltransferase Wilms' tumor 1-associated protein (WTAP) in regulating microglial polarization during ischemic stroke (IS) remains unknown. We performed bioinformatics analysis to identify m6A-related differentially expressed genes in IS and validated these genes in a mouse middle cerebral artery occlusion model and a BV2 cell oxygen-glucose deprivation/reperfusion model.

Oxidative stress controls lncRNA-mediated sow granulosa cell functions in a FoxO1-dependent manner.

Background: Oxidative stress (OS) is involved in low female fertility by altering multi-omics such as the transcriptome, miRome, and lncRNome in follicular cells and follicular fluid. However, the mechanism by which OS affects multi-omics dynamics remains largely unknown. Here, we report that OS induces lncRNome dynamics in sow granulosa cells (sGCs), which is partially dependent on the transcription factor activity of its effector, FoxO1.

Improving Glycoproteomic Analysis Workflow by Systematic Evaluation of Glycopeptide Enrichment, Quantification, Mass Spectrometry Approach, and Data Analysis Strategies.

Glycosylation is one of the most prevalent and crucial protein modifications. Quantitative site-specific characterization of glycosylation usually requires sophisticated intact glycopeptide analysis using glycoproteomics. Recent efforts have focused on the interrogation of intact glycopeptide analyses using tandem mass spectrometry.

YOLOv5s-Based Image Identification of Stripe Rust and Leaf Rust on Wheat at Different Growth Stages.

Stripe rust caused by f. sp. and leaf rust caused by , are two devastating diseases on wheat, which seriously affect the production safety of wheat.

Structural insights into the DNA-binding mechanism of BCL11A: The integral role of ZnF6.

The transcription factor BCL11A is a critical regulator of the switch from fetal hemoglobin (HbF: αγ) to adult hemoglobin (HbA: αβ) during development. BCL11A binds at a cognate recognition site (TGACCA) in the γ-globin gene promoter and represses its expression. DNA-binding is mediated by a triple zinc finger domain, designated ZnF456.

Identification of Wheat Stripe Rust Inoculum Sources and Dispersal Routes Responsible for Initial Rust Establishment in Southern Henan of China.

Wheat stripe rust (yellow rust), caused by f. sp. (), is an important airborne disease worldwide.

Soil moisture inversion based on multiple drought indices and RBFNN: A case study of northern Hebei Province.

Drought has a significant impact on crop growth and productivity, highlighting the critical need for precise and timely soil moisture estimation to mitigate agricultural losses. This study focuses on soil moisture retrieval in northern Hebei Province during July 2012, utilizing eight widely employed remote sensing drought indices derived from MODIS satellite data. These indices were cross-referenced with measured soil moisture levels for analysis.

A Universal Synthesis of Single-Atom Catalysts via Operando Bond Formation Driven by Electricity.

Single-atom catalysts (SACs), featuring highly uniform active sites, tunable coordination environments, and synergistic effects with support, have emerged as one of the most efficient catalysts for various reactions, particularly for electrochemical CO reduction (ECR). However, the scalability of SACs is restricted due to the limited choice of available support and problems that emerge when preparing SACs by thermal deposition. Here, an in situ reconstruction method for preparing SACs is developed with a variety of atomic sites, including nickel, cadmium, cobalt, and magnesium.

Protein NMR assignment by isotope pattern recognition.

The current standard method for amino acid signal identification in protein NMR spectra is sequential assignment using triple-resonance experiments. Good software and elaborate heuristics exist, but the process remains laboriously manual. Machine learning does help, but its training databases need millions of samples that cover all relevant physics and every kind of instrumental artifact.

Wheat Stripe Rust Inoculum from the Southwest Dispersed to the East Huang-Huai-Hai Region Through Southern Anhui in China.

Stripe rust, caused by f. sp. , is a continuous threat to global wheat production.

Enhancing therapeutic potential: Human adipose-derived mesenchymal stem cells modified with recombinant adeno-associated virus expressing VEGF165 gene for peripheral nerve injury.

This study aimed to investigate the therapeutic potential of human adipose-derived mesenchymal stem cells (hADSCs) modified with recombinant adeno-associated virus (rAAV) carrying the vascular endothelial growth factor 165 (VEGF165) gene in peripheral nerve injury (PNI). The hADSCs were categorized into blank, control (transduced with rAAV control vector), and VEGF165 (transduced with rAAV VEGF165 vector) groups. Subsequently, Schwann cell differentiation was induced, and Schwann cell markers were assessed.