Publications by authors named "Zhenyu Min"
Article Synopsis
- Chemoresistance in colorectal cancer (CRC) complicates treatment, and this study focuses on the role of MDM2, a ubiquitin E3 ligase, in influencing CRC cell growth and response to chemotherapy.
- Researchers analyzed the interaction between MDM2 and the transcription factor ING3, discovering that MDM2 reduces ING3 protein stability through a process called ubiquitination, which leads to increased cell proliferation and decreased apoptosis in CRC cells.
- The study also confirms, through experiments in mice, that the combined effects of MDM2 and reduced ING3 expression contribute to tumor growth and chemoresistance in colorectal cancer.
Glutamine metabolism is an important metabolic pathway for cancer cell survival, and there is a critical connection between tumor growth and glutamine metabolism. However, the role of GLS1 in hepatocellular carcinoma (HCC) progression remains to be elucidated. In this study, we reported that GLS1 expression was significantly increased in HCC tissues and correlated with serum AFP, tumor differentiation, lymphatic metastasis, TNM stage, and poorer patient outcome.
View Article and Find Full Text PDFPrevious studies have revealed that microRNA (miR)-150 can act as an oncomiR or a tumor suppressor in numerous types of hematological malignancy and solid tumor. However, the function of miR-150 in papillary thyroid carcinoma (PTC) remains elusive. The present study aimed to investigate the function of miR-150 in PTC and its underlying molecular mechanism.
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