Causal association between metabolites and age-related macular degeneration: a bidirectional two-sample mendelian randomization study.

Background: Age-related macular degeneration (AMD) is the leading cause of visual impairment in the elderly population. Accumulating evidence has revealed the possible association between metabolites and AMD. This study aimed to assess the effect of plasma metabolites on AMD and its two subtypes using a bidirectional two-sample Mendelian randomization approach.

In-Plane Adaptive Heteroepitaxy of 2D Cesium Bismuth Halides with Engineered Bandgaps on c-Sapphire.

The heteroepitaxy of 2D materials with engineered bandgaps are crucial to broaden the spectral response for their integrated optoelectronic devices. However, it is a challenge to achieve the high-oriented epitaxy and integration of multicomponent 2D materials with varying lattice constants on the same substrate due to the limitation of lattice matching. Here, in-plane adaptive heteroepitaxy of a series of high-oriented 2D cesium bismuth halide (CsBiX X = I, Br, Cl) single crystals with varying lattice constants from 8.

Correction: Environmental protection tax and green innovation of heavily polluting enterprises: A quasi-natural experiment based on the implementation of China's environmental protection tax law.

[This corrects the article DOI: 10.1371/journal.pone.

A novel homozygous mutation identified by whole exome sequencing in a consanguineous family with metachromatic leukodystrophy: a case report.

Metachromatic leukodystrophy (MLD) is a genetic lysosomal disease. Here, we investigated the role of prosaposin () gene mutations in MLD. This current case report describes a female patient who presented with motor development regression at two years and five months of age.

Effect of high sensitivity C-reactive protein on uric acid-related cardiometabolic risk in patients with coronary artery disease-a large multicenter prospective study.

Although serum uric acid (SUA) is a risk factor for cardiometabolic outcome, but it remains unclear which patients with coronary artery disease (CAD) benefit the most from SUA lowering therapy (ULT). The association of SUA level, systemic inflammation and cardiometabolic risk is still unclear. The current study is aimed to examine whether SUA-associated cardiometabolic risk is modulated by systemic inflammation in CAD patients.

Macrophage tracking with USPIO imaging and T2 mapping predicts immune rejection of transplanted stem cells.

To develop a clinical imaging method for monitoring macrophage migration to the defect site after implantation of various stem cells and evaluating immune responses in the context of knee arthritis, T2 mapping was correlated with CD68-positive cell densities in defects and the bone marrow. This study, which was approved by the Institutional Animal Care and Use Committee, used 32 New Zealand white rabbits preloaded with ultrasmall superparamagnetic iron oxide particles (USPIOs). They were divided into groups that received different stem cell implants after osteochondral defect induction.

Miniaturized, portable gustation interfaces for VR/AR/MR.

Gustation is one of the five innate sensations for humans, distinguishing from vision, auditory, tactile, and olfaction, as which is a close and chemically induced sense. Despite the fact that a handful of gustation display technologies have been developed, the new technologies still pose significant challenges in miniaturization of the overall size for portability, enriching taste options within a limited working area, supporting natural human-device interaction, and achieving precisely controlled taste feedback. To address these issues, here, we report a set of intelligent and portable lollipop-shaped taste interfacing systems covering from 2 to 9 different taste options for establishing an adjustable taste platform in virtual reality (VR), augmented reality (AR), and mixed reality (MR) environments.

Implications of baseline glycemic control by plasma glycated hemoglobin A1c on adverse outcomes in patients with coronary heart disease and type 2 diabetes mellitus: Results from the PROMISE study.

Background: The optimal glycosylated hemoglobin (HbA1c) target in type 2 diabetes mellitus (T2DM) patients remains controversial, especially in patients with concomitant coronary heart disease (CHD). This study aimed to investigate the correlation between baseline HbA1c and long-term prognosis in CHD patients with T2DM.

Methods: The study enrolled 6,839 CHD patients with T2DM and measured HbA1c at admission in a multicenter prospective observational cohort.

Asymmetric χ-translated optical frequency combs assisted by avoided mode crossing in concentric ring resonators.

χ-translated microcomb generation in microresonators that possess both χ and χ nonlinear responses opens the door for ultra-broadband integrated comb sources. The interplay between the second- and third-order nonlinearities within a fixed coupling coefficient fertilizes complicated cavity dynamics which is of paramount scientific and technological potential. However, this coupling coefficient can be drastically wavelength-dependent, which is lack of consideration in previous studies.

Widely Targeted Metabolomics Analysis Revealed the Component Differences of Borani in Different Production Areas of Datong.

Borani () has garnered significant attention due to its abundant nutritional quality. Datong, located in Shanxi Province, is recognized as one of the four major production regions for high-quality . While Datong boasts multiple production areas, the nutritional composition of daylilies varies across regions due to environmental factors and planting patterns, which remain unclear.

Applicability of soil health assessment dominated by biological indicators in facility agriculture.

The minimum data set (MDS) is widely used for soil health index (SHI) assessment, with the selection of indicators being crucial. However, biological indicators are less frequently used compared to physical and chemical indicators. This study aimed to establish a biologically-centered MDS for assessing soil health in tomato facility agriculture in Ningbo.

High-Resolution Spectroscopy of the Intermediate Impurity States near a Quantum Phase Transition.

The intermediate behavior near a quantum phase transition is crucial for understanding the quantum criticality of various competing phases and their separate origins, yet it remains unexplored for the multiple Yu-Shiba-Rusinov (YSR) states. Here, we investigated the detailed spectroscopic change of the exchange-coupling-dependent YSR states near a quantum phase transition. The initially developed one pair of YSR states, induced by the Fe vacancy in monolayer Fe(Te,Se) superconductor, are clearly resolved with high resolution showing an evolution into two pairs of YSR peaks yet with dichotomy in their spectral features as they enter the quantum phase transition region.

[Interpretation of : ].

The paper interprets the formulation, main content and characteristics of issued by World Federation of Acupuncture Societies (WFAS 007.2-2023, short for Guideline). The Guideline focuses on the clinical value of acupuncture regimen for smoking cessation and its abstinence rate, and attaches the importance to the actual needs of patients, the counseling and management of smoking cessation.