Publications by authors named "Zhenyu Kou"
Article Synopsis
- Mycobacterium abscessus skin infections are a growing concern, as traditional antibiotics often fail, leading to the need for new treatment options like aminolevulinic acid photodynamic therapy (ALA-PDT) combined with antibiotics.
- The study treated eight patients with M. abscessus infections post-cosmetic surgery using ALA-PDT and various antibiotics, finding positive results with no recurrences during follow-up.
- In vitro tests revealed that while ALA-PDT effectively killed M. abscessus, certain strains required higher doses due to their stronger biofilm formation and genetic mutations affecting metabolism, highlighting the potential for enhanced bacterial killing when using ALA-PDT alongside antibiotics.
Melatonin partially rescues defects induced by tranexamic acid exposure during oocyte maturation in mice.
Am J Physiol Cell Physiol
September 2024
Article Synopsis
Background: The epithelial-mesenchymal transition (EMT) of retinal pigment epithelial (RPE) cells participated in the development of retinal fibrosis. SB431542 is a small molecule inhibitor with inhibitory effects on the ALK4, ALK5 and ALK7. Our study aimed to explore the effect of SB431542 on the EMT of RPE cells and to provide new ideas for the treatment of retinal fibrosis.
View Article and Find Full Text PDFMitochondria are important places for the oxidative phosphorylation of glucose and the maintenance of cell oxidation and antioxidant stability. However, mitochondrial dysfunction causes cell dysfunction. Meanwhile, retinal vascular endothelial cell dysfunction may cause vascular inflammation, hemorrhage, angiogenesis, and other manifestations.
View Article and Find Full Text PDF