NAD mediated photoelectrochemical biosensor for histone deacetylase Sirt1 detection based on CuO-BiVO-AgNCs heterojunction and hybridization chain reaction amplification.

Background: Histone deacetylate Sirt1 has been involved in many important biological processes and is closely related to the occurrence and development of many diseases. Therefore, the accurate detection of Sirt1 is of great significance for the diagnosis and treatment of diseases caused by Sirt1 and the development of related drugs.

Results: In this work, a photoelectrochemical biosensor was developed for Sirt1 detection based on the NAD  mediated Sirt1 recognition and E.