Rapid and sustained response of stubborn guttate psoriasis to ustekinumab: A 52-week, two-center, one-arm, observational study.

Ustekinumab showed significant and prolonged efficacy in treating stubborn GP patients, particularly for those patients with SDD. The CARD14: rs11652075C>T may serve as a predictor of favorable treatment response.

Results of the cyclic triaxial testing on mechanically-biologically treated waste.

Accurate assessment of the dynamic strength characteristics of mechanically-biologically treated (MBT) waste is crucial for the construction and safe operation of landfill sites. Herein, samples of MBT waste from the Hangzhou Tianziling landfill were collected and subjected to consolidated undrained cyclic triaxial tests under four confinement levels and six cyclic stress ratios (CSRs). Under cyclic loading, the MBT waste exhibited a critical CSR.

Compressibility characteristics of municipal solid waste considering multiple factors.

Borehole samples were collected from a municipal solid waste (MSW) landfill in Xi'an, China, and subjected to a series of basic geotechnical and compression tests. This study aims to investigate the influence of composition, dry unit weight, moisture content, organic content, and landfill age on the compressibility of MSW. The results show that with increasing landfill age, the compressible components and organic content exhibit a decreasing trend while the dry unit weight increases.

Unmet Needs and Treatment Preference of Systemic Treatments for Moderate-to-Severe Psoriasis from the Perspectives of Patients and Dermatologists in China.

Introduction: The treatment options for moderate to severe psoriasis (msPsO) in China have been greatly increased with the approvals of biologics. However, the unmet needs and treatment preferences of systemic treatments for msPsO in China remain unclarified.

Methods: Fifty dermatologists and 300 patients with msPsO (41% with severe psoriasis) were surveyed for effectiveness, safety, treatment convenience, and treatment preferences (using a choice-based conjoint questionnaire).

Increased neutrophil-derived IL-17A identified in generalized pustular psoriasis.

Generalized pustular psoriasis (GPP) is considered to be a distinct clinical entity from psoriasis vulgaris (PV), with different clinical and histological manifestations. The pathogenesis of GPP has not been thoroughly elucidated, especially in those patients lacking interleukin (IL)36RN. In present study, we performed RNA sequence analysis on skin lesions from 10 GPP patients (4 with and 6 without IL36RN mutation) and 10 PV patients without IL36RN mutation.

Increased S. aureus colonization and reduced antimicrobial peptide expression in erythrodermic psoriasis.

Background: Erythrodermic psoriasis (EP) is a severe and rare condition characterized by prominent erythema and scaling over 75 % of the body surface area. Unlike psoriasis vulgaris (PV), EP carries high risk of systemic involvement, including superficial skin infections and sepsis, particularly those caused by Staphylococcus aureus.

Objective: To explore the microecological characteristics of EP and detect the levels of antimicrobial peptides (AMPs) in both skin and serum of EP patients.

Efficacy and safety of a noninvasive, home-based radiofrequency device for facial rejuvenation: An open-label, intraindividual controlled trial.

Background: Wrinkle formation is the most visible characteristic of facial aging. Radiofrequency (RF) technology is currently utilized to reduce facial wrinkles and contribute to skin rejuvenation.

Objective: To analyze the efficacy and safety of a noninvasive, home-based RF device applied for facial rejuvenation in Chinese people.

Dupilumab improve acquired reactive perforating collagenosis characterized by type 2 inflammation.

Background: Acquired reactive perforating collagenosis (ARPC) is a clinically challenging disease with an unclear pathogenesis.

Objective: To evaluate the efficacy and safety of dupilumab for the treatment of ARPC, and analyze the expression of type 2 inflammation-related molecules in ARPC lesions.

Methods: This retrospective cohort study included 20 patients with ARPC; 10 received dupilumab and 10 received conventional therapy.

Dupilumab effectively and rapidly treats bullous pemphigoid by inhibiting the activities of multiple cell types.

Background: Bullous pemphigoid (BP) is an autoimmune skin-blistering disease. Systemic corticosteroids remain the first line treatment for moderate-to-severe BP with the potential for severe adverse events. Dupilumab has emerged as an alternative option for BP patients.

Increased soluble endoglin levels in newly-diagnosed type 2 diabetic patients are associated with endothelial dysfunction.

Endothelial dysfunction (ED) contributes to the pathologic process underlying macrovascular complications, a common complication of type 2 diabetes mellitus (T2DM). Soluble endoglin (sEng) shed from the extracellular domain of the entire endoglin molecule blocks endothelial protection mediated by transforming growth factor-beta 1 (TGF-β1). The reactive hyperemia index (RHI), which is determined by reactive hyperemia peripheral arterial tonometry (RH-PAT), is a new index with which to evaluate ED.

Effects of moisture content and landfill age on the shear strength properties of municipal solid waste in Xi'an, China.

With the continued expansion of waste landfills, accidents may occur if the landfills are not properly stabilized. In this study, samples of municipal solid waste (MSW) from a waste landfill in Xi'an, China were collected through on-site drilling. Considering the effects of nine landfill ages (1, 2, 3, 11, 12, 13, 21, 22, and 23 y) and six moisture contents (natural, 20, 40, 60, 80, and 100%), 324 groups of MSW were tested in the laboratory using a direct shear test apparatus.

Adaptive and innate immune pathogenesis of bullous pemphigoid: A review.

Bullous pemphigoid (BP) is an autoimmune blistering disease that primarily affects elderly individuals. The presentation of BP is heterogeneous, typically manifesting as microscopic subepidermal separation with a mixed inflammatory infiltrate. The mechanism of pemphigoid development is unclear.

Laboratory studies of the dynamic characteristics of mechanically-biologically treated waste.

The dynamic characteristics of landfills under seismic loading and their stability strongly depend on the cyclic stress-strain characteristics of the waste. An accurate assessment of the dynamic characteristics of mechanically-biologically treated (MBT) waste is crucial to the construction and safe operation of landfills. Considering the effects of the confining pressure, strain amplitude, and loading frequency, 72 sets of consolidated undrained cyclic triaxial (CTX) tests were conducted on MBT waste.

Predictive Value of Exercise Blood Pressure Changes for Orthostatic Hypotension in Patients With Parkinson's Disease.

Background And Purpose: Orthostatic hypotension (OH) is common in patients with Parkinson's disease (PD). Early recognition OH is required with sensitive assessments. The purpose of this study was to determine whether blood pressure (BP) changes during exercise can predict the occurrence of OH in PD.

Impact of Exercise Training at Different Intensity Levels on Cardiac Function and Exercise Capacity in Patients with Chronic Heart Failure: A Prospective Cohort Study.

Objective: To investigate training at different intensity levels on cardiac function, exercise capacity, and health-related quality of life in patients with chronic heart failure.

Methods: This prospective cohort study enrolled patients with chronic heart failure at Beijing Rehabilitation Hospital, Beijing, China from January 2018 to January 2020. Participants received conventional therapy (non-exercise group) or therapy plus cycle ergometer exercises at an intensity of 80% anaerobic threshold (EA group) and Δ50% power above anaerobic threshold (EB group) for 12 weeks.

A review on settlement models of municipal solid waste landfills.

Currently, landfill is the most common, economical, and convenient method for municipal solid waste (MSW) disposal in countries around the world. MSW has a complex composition and special engineering characteristics, which lead to a very complex settlement mechanism in MSW landfills. This article reviews the description of this settlement mechanism in the existing literature and classifies it into stress-related mechanisms, biodegradation processes of organic substances, water-related mechanisms and physical and chemical processes of inorganic components.

Strength characteristics of geosynthetic reinforced mechanically biologically treated waste by triaxial test.

The reinforcement strength characteristics of mechanically biologically treated (MBT) waste were studied by conducting consolidated undrained triaxial tests with MBT waste collected from the Hangzhou Tianziling landfill pilot project. In the tests, the effects of the reinforcement material used (geomembrane, geotextile, and geogrid) and the number of reinforcement layers used (one, two, and three layers) were assessed. The results showed the following: (1) even through the axial strain increases up to 25%, the deviator stress of MBT waste could not reach a well-defined peak; (2) the reinforcement effect is related to the type of reinforcement material, with geogrid exhibiting the best reinforcement effect and geomembrane the worst; (3) the strength ratio of reinforced MBT waste is related to the confining pressure and the number of reinforcement layers, with a greater strength ratio in the MBT waste attained with a lower confining pressure in a logarithmic relationship and a greater strength ratio in the MBT waste attained with a greater number of reinforcement layers in a linear relationship; (4) the reinforced MBT waste shear strength parameter variation ranges for the cohesion (c), internal friction angle (φ), effective cohesion (c'), and effective internal friction angle (φ') are 3.

One-lung ventilation patients: Clinical context of administration of different doses of dexmedetomidine.

Background: Open and endoscopic thoracic surgeries improve surgical exposure by One-lung ventilation (OLV). The aim of this study was to investigate the effects of different doses of dexmedetomidine on inflammatory response, oxidative stress, cerebral tissue oxygen saturation (SctO2) and intrapulmonary shunt in patients undergoing one-lung ventilation (OLV).

Methods: Seventy-five patients undergoing open pulmonary lobectomy in our hospital from January 2016 to December 2017 were enrolled and randomly divided into high-dose dexmedetomidine group (group D1, 1 mg/kg, n=25), low-dose dexmedetomidine group (group D2, 0.

Clinical Efficacy of Ulinastatin Combined with Meglumine Adenosine Cyclophosphate in the Treatment of Acute Myocardial Infarction.

Ulinastatin, a common adjuvant drug in the clinical treatment of acute circulatory failure, has a good effect on various inflammatory diseases. In this study, we aim to explore the clinical efficacy of ulinastatin combined with meglumine adenosine cyclophosphate in patients with acute myocardial infarction (AMI) and its effect on cardiac function and endothelial function of patients. 100 AMI patients treated in our hospital (February 2020-October 2020) were randomly chosen and divided into group J and group Q, with 50 cases in each group.

RNA-Seq Transcriptomic Analysis of Green Tea Polyphenols Modulation of Differently Expressed Genes in Enterococcus faecalis Under Bile Salt Stress.

Enterococcus faecalis (E. faecalis) belongs to lactic acid bacteria which can be used as a probiotic additive and feed, bringing practical value to the health of humans and animals. The prebiotic function of tea polyphenols lays a foundation for green tea polyphenols (GTP) to repair the adverse changes of E.