Susceptibility vessel sign in patients with subacute ischemic stroke.

Background: Limited information exists regarding susceptibility vessel sign (SVS) found beyond 24 hours after stroke onset. This study aimed to compare the presence and quantitative measurements of SVS between the large artery arteriosclerosis (LAA) subtype and the cardioembolism (CE) subtype in patients with subacute stroke.

Methods: We retrospectively analyzed stroke survivors with the LAA subtype or the CE subtype who had occlusion or severe stenosis of the responsible intracranial large vessel and who had undergone susceptibility-weighted imaging (SWI) between day 3 and day 14 after stroke onset at Peking University First Hospital from December 2017 to January 2022.

Cerebrospinal Fluid sTREM2 Has Paradoxical Association with Brain Structural Damage Rate in Early- and Late-Stage Alzheimer's Disease.

Background: Recently it has been proposed that microglial response has a stage-dependent effect on the progression of Alzheimer's disease (AD). Cerebrospinal fluid (CSF) sTREM2 has emerged as a promising microglial activation marker.

Objective: To test the stage-dependent role of microglia by studying the association between baseline sTREM2 and dynamic brain structural changes in AD and mild cognitive impairment (MCI) patients.