Exploring the risk and predictive study of outdoor air pollutants on the incidence and mortality of HIV/AIDS.

Background: The rising incidence of environmental pollution has heightened concerns regarding the impact of pollutant variations on public health.

Methods: Time series analysis models and BP neural network models were utilized to investigate both univariate and multivariate predictions of HIV/AIDS cases. To evaluate the combined effects of pollutants on HIV/AIDS cases, we employed weighted quantile sum (WQS) regression, a quantile-based g-computation approach (Qgcomp) and Bayesian kernel machine regression (BKMR).

Lycopene Prevents Amyloid [Beta]-Induced Mitochondrial Oxidative Stress and Dysfunctions in Cultured Rat Cortical Neurons.

Brains affected by Alzheimer's disease (AD) show a large spectrum of mitochondrial alterations at both morphological and genetic level. The causal link between β-amyloid (Aβ) and mitochondrial dysfunction has been established in cellular models of AD. We observed previously that lycopene, a member of the carotenoid family of phytochemicals, could counteract neuronal apoptosis and cell damage induced by Aβ and other neurotoxic substances, and that this neuroprotective action somehow involved the mitochondria.