Numerical modeling of an ASE suppression and power scalable approach in 1908 nm LMA-TDFO.

High-power Tm-doped fiber lasers operating at short wavelengths (< 1940 nm) are widely used in biomedical engineering, remote sensing, and pumping Ho-doped solid-state lasers. However, it is challenging to increase their output power. Amplified spontaneous emission (ASE) is a major bottleneck in scaling the power of Tm-doped fiber lasers operating at short wavelengths.

Safety and Effectiveness Analysis of Different Surgical Methods for Intrahepatic Bile Duct Stones.

Background: Intrahepatic bile duct stones, a prevalent condition within hepato-biliary diseases, present a considerable challenge due to the high rates of recurrence, complications, and difficulty in treatment. Selecting an optimal surgical approach is vital for effective stone clearance and minimizing patient morbidity. While laparoscopic hepatectomy and percutaneous transhepatic choledochoscopy are established modalities, their comparative efficacy and safety profiles necessitate further investigation to inform clinical decision-making.

Dynamic Characteristics of Plasma in Ultrasonic-Assisted Narrow-Gap Laser Welding with Filler Wire.

Laser welding with filler wire was applied to Q345D in a narrow gap under ultrasonic assistance, and the dynamic characteristics of plasma were studied by high-speed imaging and spectral acquisition. The results showed that the plasma area decreased gradually with increasing distance between the ultrasonic loading position and welding seam. The electron density and temperature of the plasma with ultrasonic assistance were higher than those without ultrasound.

Fault detection sensitivity analysis and optimization of the few-mode fiber link under a dynamic spatial mode crosstalk cumulative effect.

Due to the cumulative effect of dynamic spatial mode crosstalk, it is difficult to obtain the amplitude distribution of backscattering with high purity. Hence, the fault detection sensitivity (FDS) of the few-mode fiber (FMF) link is deteriorated, and the fault location accuracy is limited. This work investigates the characteristics and optimization method of FDS for the FMF link under the dynamic spatial mode crosstalk cumulative effect.

Fault detection performance of a multi-mode transmission reflection analysis for a few-mode fiber link.

We propose a novel monitoring technique based on multi-mode transmission reflection analysis for a long-reach few-mode fiber (FMF) based mode division multiplexing system. By launching unmodulated continuous-wave optical light modes into the corresponding spatial modes of the FMF, the transmitted and reflected or backscattered optical powers can be measured and quantitatively analyzed to accurately characterize and locate the fault. The influences of the capture fraction, attenuation coefficient, and Rayleigh backscattering coefficient are discussed, and simulation results show that the proposed method can realize the fault location of the FMF link.

Analysis of characteristics of few-mode fiber fusion splicing under dynamic spatial modecrosstalk.

In this paper, an analytical model of the fusion splicing loss of few-mode fiber (FMF) under the condition of dynamic crosstalk is proposed. Under different dynamic spatial modal crosstalk caused by fusion mismatches and rotation angles, we analyze the variation trend of the fusion splicing loss characteristics of FMF with ,, and , respectively. Simulation results show that under the condition of axial misalignment introducing modal crosstalk, the splice loss of the and modes is higher than that of .

Controlling Nutritional Status (CONUT) Score as a New Indicator of Prognosis in Patients With Hilar Cholangiocarcinoma Is Superior to NLR and PNI: A Single-Center Retrospective Study.

Background: Currently, many nutritional indicators, including controlling nutritional status score (CONUT), can be used to assess a patient's nutritional status and have been reported as reliable predictors of multiple malignancies. However, the value of CONUT score in predicting postoperative outcomes in patients with hilar cholangiocarcinoma has not been explored. In this study, its predictive value will be discussed and compared with the known predictors the neutrophil lymphocyte ratio (NLR) and prognostic nutritional index (PNI).

Quantum image processing algorithm using edge extraction based on Kirsch operator.

In this work, a quantum image processing algorithm is developed using the edge extraction method together with the Kirsch operator. In our approach, novel enhanced quantum representation (NEQR) is employed as the image representation model for processing quantum image, which generates results of edge extraction using the Kirsch operator. The proposed algorithm can perform real-time image processing with high accuracy.

Searching for differentially expressed proteins in spinal cord injury based on the proteomics analysis.

Aims: We aimed to identify potential differentially expressed proteins that play roles in the spinal cord injury.

Materials And Methods: The mouse model of spinal cord injury was firstly built, followed by grip strength evaluation. Then, isobaric tags for relative and absolute quantization (iTRAQ) analysis was used to identify differentially expressed proteins at 1, 2, 3 and 8 weeks after spinal cord injury.

Silencing of the gene suppresses proliferation and invasion of hepatocellular carcinoma HepG2 cells.

Objectives: Overexpression of human trophoblast cell surface antigen 2 (Trop2) has been observed in many cancers; however, its roles in proliferation, apoptosis, migration, and invasion of hepatocellular carcinoma (HCC) remain unclear. Thus, this study aimed to characterize the function of Trop2 in HCC.

Methods: Trop2 protein expression was detected by immunohistochemistry in HCC tissues.

Nobiletin attenuates lipopolysaccharide/D‑galactosamine‑induced liver injury in mice by activating the Nrf2 antioxidant pathway and subsequently inhibiting NF‑κB‑mediated cytokine production.

Inflammation and oxidative stress serve an important role in the development of lipopolysaccharide/D-galactosamine (LPS/GalN)‑induced acute liver injury. Nobiletin, which is found in high quantities in the peel of citrus fruits, is able to modulate immune responses, including inflammatory response and oxidative stress. The present study aimed to evaluate the protective effects of nobiletin on LPS/GalN‑induced acute liver injury.

Diagnostic role of staging laparoscopy in a subset of biliary cancers: a meta-analysis.

Background: Accurate preoperative radiological staging of biliary cancers remains difficult. Despite the improvement in imaging techniques, a number of patients with biliary cancers who undergo laparotomy are ultimately found to have unresectable diseases. The goals of staging laparoscopy (SL) are to rule out metastatic and locally advanced unresectable diseases and better define locally advanced unresectable diseases.

Aspirin regulates hepatocellular lipid metabolism by activating AMPK signaling pathway.

Aspirin has been reported to regulate lipid metabolism. However, the mechanism underlying the regulation is not clear. We presently investigated aspirin's promotion of AMP-activated protein kinase (AMPK) pathway activation in human hepatoma HepG2 cells by examining AMPK expression, the promotion of AMPK activation.