Publications by authors named "Zhenting Hao"
Article Synopsis
- Myostatin (MSTN) is a protein that normally limits muscle growth, and researchers are investigating how it interacts with gut bacteria.
- In a study with myostatin knockout (MSTN-KO) cattle, researchers found increased muscle area and levels of branched-chain amino acids (BCAAs), which are crucial for muscle energy.
- The results showed a significant rise in a specific gut bacterium, Prevotella, linked to enhanced BCAA production and transport, indicating that the absence of MSTN boosts muscle growth through improved BCAA metabolism and gut microbiota interactions.
The myostatin () gene also regulates the developmental balance of skeletal muscle after birth, and has long been linked to age-related muscle wasting. Many rodent studies have shown a correlation between and age-related diseases. It is unclear how and age-associated muscle loss in other animals are related.
View Article and Find Full Text PDFChinese Yellow Cattle, an ancient and domesticated breed for draft service, provide unique animal genetic resources with excellent genetic features, including crude feed tolerance, good stress resistance, strong adaptability, and tender meat quality; however, their production performance and meat yield are significantly inferior. Herein, the myostatin gene (), a negative regulator of skeletal muscle development, was knocked out by CRISPR/Cas9 technology. Eight gene-edited bull calves (MT) were born, and six of them are well-developed.
View Article and Find Full Text PDF[Correlation of the quality of life with the inspiratory capacity in patients with chronic obstructive pulmonary disease].
Zhonghua Jie He He Hu Xi Za Zhi
April 2010
Objective: To evaluate the correlation of the quality of life in patients with chronic obstructive pulmonary disease (COPD) with the lung function tests, especially the inspiratory capacity (IC).
Methods: Sixty-two stable COPD patients were enrolled between Jan. 2006 and Mar.
[Characteristics of non-symptomatic chronic obstructive pulmonary disease patients].
Zhonghua Jie He He Hu Xi Za Zhi
August 2005
Objective: To evaluate the epidemiological characteristics of non-symptomatic chronic obstructive pulmonary disease (COPD) patients in a rural area in Beijing.
Methods: The data of 1,624 people aged more than 40 in 5 villages in Yanqing county in Beijing were collected. Information of medical history and symptom were obtained, and physical examination and lung function test were performed.
[Epidemiological data of chronic obstructive pulmonary disease in Yanqing County in Beijing].
Beijing Da Xue Xue Bao Yi Xue Ban
April 2005
Objective: To evaluate the epidemiological characteristic and risk factors of chronic obstructive pulmonary disease (COPD) in the rural area of Beijing.
Methods: The data of 1,624 people aged more than 40 in 5 villages in Yanqing County in Beijing were collected. The habitation condition, life and cooking habit, smoking history, personal history and family history were asked, and their physical examinations and lung function tests were conducted.